The Contribution of Mosaic Chromosomal Alterations to Schizophrenia.

Background: Mosaic chromosomal alterations are implicated in neuropsychiatric disorders, but the contribution to schizophrenia (SCZ) risk for somatic copy number variations (sCNVs) emerging in early developmental stages has not been fully established.

Methods: We analyzed blood-derived genotype arrays from 9715 patients with SCZ and 28,822 control participants of Chinese descent using a computational tool (MoChA) based on long-range chromosomal information to detect mosaic chromosomal alterations. We focused on probable early developmental sCNVs through stringent filtering.

Design and experiment of a shovel-tooth removal end-effector for abnormal plants in hybrid rape breeding based on MBD-DEM coupling.

In view of the problem that removing abnormal plants in breeding rape requires a large amount of labor and is inefficient, combined with the planting requirements of breeding rape, a shovel-tooth end-effector was designed, and a shovel-tooth removal test bench was built. A simulation model based on MBD (Multibody Dynamics)-DEM (Discrete Element Method) coupling was constructed. Then we conducted a Box-Behnken test with four factors and three levels.

ErbB2 as a predictive biomarker for Parkinson's disease based on research with RPPA technology and in vivo verification.

Aims: This study aims to reveal a promising biomarker for Parkinson's disease (PD) based on research with reverse phase protein array (RPPA) technology for the first time and in vivo verification, which gains time for early intervention in PD, thus increasing the effectiveness of treatment and reducing disease morbidity.

Methods And Results: We employed RPPA technology which can assess both total and post-translationally modified proteins to identify biomarker candidates of PD in a cellular PD model. As a result, the phosphorylation (pY-1248) of the epidermal growth factor receptor (EGFR) ErbB2 is a promising biomarker candidate for PD.

A laser-induced FeO-graphene nanozyme for catalytic-photothermal synergetic bactericidal applications.

Laser-induced FeO nanoparticle-modified three-dimensional macroporous graphene is fabricated as a near-infrared light responsive nanozyme a facile and laser-scanning method under ambient conditions for the first time, showing an excellent catalytic-photothermal synergetic bactericidal ability under a low dose of HO (0.1 mM) and short irradiation time (5.0 min).

The alleviative effect of s L. extract against Parkinson's disease-like pathology in zebrafish the involvement of autophagy activation.

Introduction: Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder. However, effective preventative or therapeutic agents for PD remain largely limited. Marigold L.

Productivity model and experiment of field crop spraying by plant protection unmanned aircraft.

Traditional agricultural production requires numerous human and material resources; however, agricultural production efficiency is low. The successful development of plant protection unmanned aerial vehicles (UAVs) has changed the operation mode of traditional agricultural production, saving human, material, and financial resources and significantly improving production efficiency. To summarize the process of improving the productivity of plant protection UAVs, this study established a productivity calculation model of UAVs based on the time composition of the UAV agricultural plant protection process, including spraying, turning, replenishment, and transfer times.

Benzoresorcinol induces developmental neurotoxicity and injures exploratory, learning and memorizing abilities in zebrafish.

Benzophenones (BPs) are a class of UV absorber commonly used in skin care products like sunscreens. With its wide range of application, its environmental and human hazards have received much attention in recent days. Previous studies on the toxicity of BPs mainly focused on its endocrine-disrupting effects, but there are limited studies on its neurodevelopment and neurotoxicity.

Ameliorative effect of Gastrodia elata Blume extracts on depression in zebrafish and cellular models through modulating reticulon 4 receptors and apoptosis.

Ethnopharmacological Relevance: Gastrodia elata Blume (G. elata), a traditional Chinese herb, known as "Tian Ma", is widely used as a common medicine and diet ingredient for treating or preventing neurological disorders for thousands of years in China. However, the anti-depressant effect of G.

Protective Effect of Chlorogenic Acid and Its Analogues on Lead-Induced Developmental Neurotoxicity Through Modulating Oxidative Stress and Autophagy.

Lead (Pb) is among the deleterious heavy metal and has caused global health concerns due to its tendency to cause a detrimental effect on the development of the central nervous system (CNS). Despite being a serious health concern, treatment of Pb poisoning is not yet available, reflecting the pressing need for compounds that can relieve Pb-induced toxicity, especially neurotoxicity. In the quest of exploring protective strategies against Pb-induced developmental neurotoxicity, compounds from natural resources have gained increased attention.

The possible hormetic effects of fluorene-9-bisphenol on regulating hypothalamic-pituitary-thyroid axis in zebrafish.

Fluorene-9-bisphenol (BHPF) is a bisphenol A substitute, which has been introduced for the production of so-called 'bisphenol A (BPA)-free' plastics. However, it has been reported that BHPF can enter living organisms through using commercial plastic bottles and cause adverse effects. To date, the majority of the toxicologic study of BHPF focused on investigating its doses above the toxicological threshold.