Development and validation of a nomogram for predicting model for delirium after stroke.

Purpose: To explore the risk factors of delirium in patients with stroke and develop a nomogram model to predict the occurrence of delirium.

Methods: Convenience sampling was used to select 502 patients with stroke admitted to a tertiary hospital with a neurology specialty in Tianjin from December 2023 to June 2024, who were categorized into the delirium group (n=141) and the non-delirium group (n=361) using the ICU Patient Ambiguity of Consciousness Assessment Scale. We explored the independent risk factors for the occurrence of delirium through univariate and multifactorial logistic regression analyses, established a risk prediction model, developed a nomogram, and validated the model both internally and externally.

Intervening with nanozymes in aging-related diseases: Strategies for restoring mitochondrial function.

The decline in mitochondrial function has been identified as one of the central pathological mechanisms underlying a variety of aging-related diseases. Nanozymes are nanomaterials with intrinsic enzyme-like properties and are important alternatives to natural enzymes. As emerging biocatalysts, nanozymes exhibit significant potential in mimicking the activity of natural enzymes, enhancing mitochondrial function, and offering novel therapeutic strategies for aging-related conditions.

A sensing platform based on zinc-porphyrin derinative in hexadecyl trimethyl ammonium bromide (CTAB) microemulsion for highly sensitive detection of theophylline.

A new porphyrin-based sensing platform in hexadecyl trimethyl ammonium bromide (CTAB) microemulsion is developed for highly sensitive detection of theophylline. In this sensing system, the zinc-porphyrin-cinnamic acid conjugate (Zn-TPPCA) works as fluorescence probe while theophylline can decrease fluorescence intensity of the probe. Further studies indicate the linear relationship between the fluorescence quenching value and the concentration of theophylline within a given range.

Determination of ultra trace amounts of metronidazole by 3-phenyl-N-[4-(10,15,20-triphenyl-porphyrin-5-yl)-phenyl]- acrylamide as the fluorescence spectral probe in CTAB microemulsion.

In this work, 3-Phenyl-N-[4-(10,15,20-triphenyl-porphyrin-5-yl)-phenyl]- acrylamide (TPPCA) was synthesized for the determination of metronidazole (MTZ). It was found that the type of fluorescence quenching was static quenching determined by Stern-Volmer plot and UV absorption spectroscopy, and thermodynamic related parameters were also obtained. Furthermore, the corresponding measurement conditions: the acidity of the system, the type of surfactant, the concentration of TPPCA and the sequence of reagent addition were optimized.

Kinetic studies on oxygen releasing of HBOC and red blood cells as fluids and factors affecting the process.

Red blood cells (RBCs) possess intact cyto-architectures while haemoglobin (Hb) is a cell-free, homogeneous solution. Both RBCs and Hb are generalized oxygen carriers. In this paper, kinetic studies on oxygen-releasing of high concentration of Hb and RBCs under various conditions were carried out regarding Hb and RBCs as fluids.