Store-operated calcium entry-associated regulatory factor regulates airway inflammation and airway remodeling in asthma mice models.

Store-operated calcium entry (SOCE) is involved in the pathogenesis of airway inflammation and remodeling in asthma. Store-operated calcium entry-associated regulatory factor (SARAF) can downregulate SOCE. We sought to investigate the role of SARAF in the regulation of airway inflammation and remodeling in asthma mice models, as well as in the functional regulation of human airway smooth muscle cells (hASMCs).

Acute toxicity and health effect of perfluoroisobutyronitrile on mice: a promising substitute gas-insulating medium to SF.

Perfluoroisobutyronitrile (CFN) is a new eco-friendly gas insulation medium that has potential to replace the most greenhouse gas sulfur hexafluoride (SF) used in power industry. In order to ensure the engineering application safety, an in-depth assessment of the acute inhalation toxicity of CFN gas mixture is required. This article revealed gender differences in male and female mice after exposure to CFN and the physiological recovery characteristics of surviving mice by means of 4 h acute inhalation toxicity tests, hematological determinations and histopathological examination.

Neuropeptide Y knockdown in the dorsomedial hypothalamus improved basal and obesity-induced decrease in bone mass density.

Objective: Neuropeptide Y (NPY) has been shown to have a prominent role in the control of bone formation through the regulation of osteoblast activity. We aimed to investigate the role of hypothalamus-derived NPY in bone metabolism.

Methods: Accordingly, adeno-associated virus (AAV)-mediated RNA interference (RNAi) was utilized to downregulate NPY gene expression in rats fed regular chow (RC) or a high-fat diet (HF).

Assessment on the toxicity and application risk of C4F7N: A new SF6 alternative gas.

CFN (fluorinated nitrile) gas mixture has been utilized as the gas insulating medium to replace the most greenhouse gas SF (sulphur hexafluoride). Nowadays, there are few reports on the toxicity mechanism of CFN and studies on the application risk of CFN is insufficient. In this paper, we carried out acute toxicity tests for CFN gas systematically.