Publications by authors named "Baojuan Wu"
Article Synopsis
- Inflammatory bowel disease (IBD) is marked by chronic inflammation in the digestive tract and involves blood vessel formation (angiogenesis) as a key factor in its progression.
- Ginsenoside Rg3 from ginseng has anti-angiogenic effects but suffers from poor absorption in the body, prompting the development of a new delivery system using a thermosensitive hydrogel called Gel-Rg3, made with Pluronic F-127 and F-68.
- Gel-Rg3 demonstrated better safety and effectiveness against IBD in lab tests and mouse models by promoting drug retention in the intestine and inhibiting harmful blood vessel formation, offering new treatment strategies for managing IBD.
Drug delivery systems based on nanoparticles still face challenges of low efficacy and an inability to track treatment effects in tumor therapy due to biological barriers. This limitation hinders clinicians' ability to determine treatment effects and proper drug dosages, thus, ultimately impeding the further application and transformation of nanoplatforms. To address this challenge, an all-in-one nanoplatform for therapy and imaging is proposed.
View Article and Find Full Text PDFMitochondria in breast cancer play a critical role in survival and adaptation to dynamic environments. Thus, targeting mitochondria emerges as a promising therapeutic strategy for breast cancer. However, the adaptive unfolded protein response in mitochondria (UPR) due to mitochondrial unspecific distribution might contribute to diminished therapeutic outcomes.
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- Metastasis is the leading cause of breast cancer deaths, with research highlighting the significance of the m6A modification and its regulators in this process.
- The study found that high levels of the m6A reader IGF2BP1 are linked to metastasis in breast cancer patients, as it promotes distant spread of the disease.
- The USP10 protein was identified as a key regulator that stabilizes IGF2BP1, affecting its ability to bind m6A sites on CPT1A mRNA, thereby contributing to increased metastasis and potentially serving as a therapeutic target.