Publications by authors named "Baogen Zhang"
Article Synopsis
- The study aimed to compare the effectiveness and safety of hepatic arterial infusion chemotherapy (HAIC) versus transarterial chemoembolization (TACE) for patients with high-risk hepatocellular carcinoma (hHCC).
- A total of 1,765 patients were analyzed, and after adjusting for differences (using propensity score matching), the HAIC group showed superior outcomes in progression-free survival (PFS), overall survival (OS), and response rates compared to the TACE group.
- The findings suggest that HAIC offers better disease control, especially for larger tumors and specific patient demographics, while maintaining comparable long-term survival and safety profiles.
Article Synopsis
- Breast cancer is a major health issue in women and is associated with metabolic dysfunction, particularly related to mitochondrial metabolism, but the impact of mitochondrial metabolism-related genes (MMRGs) on breast cancer prognosis is not fully understood.
- Researchers developed a risk score model using MMRGs from various databases and found that a 12-gene model could predict patient survival and was an independent factor alongside traditional clinical metrics.
- Analysis showed that patients categorized as low-risk had better immune responses and were more sensitive to specific anti-tumor drugs, indicating that understanding MMRG characteristics can enhance treatment strategies and prognostic predictions for breast cancer patients.
Article Synopsis
- A protective ileostomy is often used after laparoscopic rectal cancer surgery to prevent complications like anastomotic leakage, but its necessity is debated.
- A meta-analysis of 525 studies indicated no significant difference in postoperative wound infections between patients with and without ileostomies, although non-ostomate patients showed higher rates of anastomotic leaks.
- The findings suggest that ileostomy may be effective in reducing the risk of anastomotic leakage without increasing infection risks, pointing towards its cautious use after surgery.
This meta-analysis was conducted to evaluate the effect of microinvasive and open operations on postoperative wound complications in low rectal carcinoma patients. Research on limited English has been conducted systematically in PubMed, Embase, Cochrane Library and Web of Science. The date up to the search was in August 2023.
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- Circ_0084615 is a circular RNA associated with colorectal cancer (CRC), found to be overexpressed in CRC tissues, linked to worse patient outcomes.
- The study used various methods, including cell line experiments and animal models, to show that knocking down circ_0084615 decreased CRC cell growth and spread while revealing its role as a sponge for miR-599, impacting DNMT3A mRNA levels.
- Overall, circ_0084615 promotes tumor growth in CRC by regulating miR-599 and DNMT3A, suggesting it could be a target for new CRC therapies.
Article Synopsis
- Gastric cancer is a prevalent type of cancer with high rates of both incidence and death, and the study focuses on the role of microRNA, specifically miR‑204‑5p, in this disease.
- The research found that miR‑204‑5p is downregulated in gastric cancer cells, and its overexpression can significantly reduce cell proliferation, migration, and invasion, while increasing apoptosis in these cells.
- miR‑204‑5p was shown to directly target the HER‑2 gene, suggesting that it could serve as a potential therapeutic target for treating gastric cancer by promoting anti-tumor effects.
Objectives: The purpose of this study was to introduce a new narrow band imaging (NBI) endoscopic classification for the diagnosis of vocal cord leukoplakia.
Study Design: Case series.
Methods: From January 2010 to February 2018, a total of 120 cases of vocal cord leukoplakia were enrolled in this study.