Calcium alginate-encapsulated propolis microcapsules: Optimization, characterization, and preservation effects on postharvest sweet cherry.

The increasing consumption of fresh fruits and vegetables has led to the development of eco-friendly and active preservation materials which have slow-release effect of antioxidant/antifungal agents. The propolis microcapsules (PM), utilizing calcium alginate as the wall material, incorporating ethanolic extract of propolis (EEP) as the core material, were prepared by ionic gelation method and conducted a investigation of its characteristics After optimization by single factor experiment and theoretical response models, PM which was prepared by dropping 9.3 g L 100 mL sodium alginate solution containing 9.

Role of , , and in determining the prognosis of patients with lung adenocarcinoma.

Background: Non-small cell lung cancer (NSCLC) accounts for about 85% of lung cancers, and is the leading cause of tumor-related death. Lung adenocarcinoma (LUAD) is the most prevalent subtype of NSCLC. Although significant progress of LUAD treatment has been made under multimodal strategies, the prognosis of advanced LUAD is still poor due to recurrence and metastasis.

Caffeic acid enhances the postharvest quality by maintaining the nutritional features and improving the aroma volatiles for nectarine fruit.

Maintaining the quality of postharvest nectarine fruit is considerably challenging owing to their vigorous metabolism processes. This study explored the effectiveness of the natural preservative caffeic acid in extending the shelf-life and improving the flavor quality of nectarine. The decay rate of caffeic acid-treated fruit was only 40.

Integrated Metabolome, Transcriptome and Long Non-Coding RNA Analysis Reveals Potential Molecular Mechanisms of Sweet Cherry Fruit Ripening.

Long non-coding RNAs (lncRNAs), a class of important regulatory factors for many biological processes in plants, have received much attention in recent years. To explore the molecular roles of lncRNAs in sweet cherry fruit ripening, we conducted widely targeted metabolome, transcriptome and lncRNA analyses of sweet cherry fruit at three ripening stages (yellow stage, pink stage, and dark red stage). The results show that the ripening of sweet cherry fruit involves substantial metabolic changes, and the rapid accumulation of anthocyanins (cyanidin 3-rutinoside, cyanidin 3-O-galactoside, and cyanidin 3-O-glucoside) is the main cause of fruit coloration.

In-cell bioluminescence resonance energy transfer (BRET)-based assay uncovers ceritinib and CA-074 as SARS-CoV-2 papain-like protease inhibitors.

Papain-like protease (PLpro) is an attractive anti-coronavirus target. The development of PLpro inhibitors, however, is hampered by the limitations of the existing PLpro assay and the scarcity of validated active compounds. We developed a novel in-cell PLpro assay based on BRET and used it to evaluate and discover SARS-CoV-2 PLpro inhibitors.

Reactive Synthesis for Porous (MoY)AlC Ceramics through Mo, Y, Al and Graphite Powders.

Through an activation reaction sintering method, porous (MoY)AlC ceramics were prepared by Mo, Y, Al, and graphite powders as raw materials. The phase composition, microstructure, element distribution, and pore structure characteristics were comprehensively studied using X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), Archimedes method, and bubble point method. A detailed investigation was conducted on the influence of sintering temperature on the phase composition.

interaction of naphthoquine with ivermectin, atovaquone, curcumin, and ketotifen in the asexual blood stage of 3D7.

Unlabelled: Naphthoquine is a promising candidate for antimalarial combination therapy. Its combination with artemisinin has demonstrated excellent efficacy in clinical trials conducted across various malaria-endemic areas. A co-formulated combination of naphthoquine and azithromycin has also shown high clinical efficacy for malaria prophylaxis in Southeast Asia.

Synthesizing Benzotriazole Group-Terminated Carbon Dots as Multifunctional Additives of Poly(ethylene glycol).

Long running-in period and corrosion problems have greatly hindered the practical applications of poly(ethylene glycol) (PEG) lubricants. In this work, benzotriazole group-terminated carbon dots (BT-CDs) were specifically synthesized through a facile solvothermal method. The benzotriazole groups on BT-CD surfaces not only imparted them excellent dispersibility in the PEG base oil but also brought in outstanding anticorrosion ability for BT-CDs.

Research on Flesh Texture and Quality Traits of Kiwifruit (cv. Xuxiang) with Fluctuating Temperatures during Cold Storage.

Kiwifruits are often exposed to various temperature fluctuations (TFs) during postharvest transportation and storage. To evaluate the effect of TFs on the qualities of kiwifruits during storage, kiwifruits were stored at 2 °C, 2 °C or 5 °C (TF2 °C-5 °C, alternating every 12 h), 2 °C or 7 °C (TF2 °C-7 °C, alternating every 12 h) for 3 d before long time storage at 2 °C. Observations revealed that kiwifruits stored at a constant 2 °C showed the lowest loss of weight and vitamin C because of minimized ethylene production and respiratory rate compared with that of TF2 °C-5 °C and TF2 °C-7 °C.

Synthesis of Polymer-Grafted Carbon Dots Serving as Multifunctional Lubricant Additives with Excellent Tribological Performance and Additional Rust Resistance Function for Steel/Steel Contact.

Poly(bis(2-ethylhexyl) phosphoric) methacrylic anhydride-grafted carbon dots (CD--PEPMA) have been controllably synthesized and used as multifunctional lubricant additives of poly(ethylene glycol) (PEG200). The polymers on the surfaces of CD--PEPMA not only endow them with particularly excellent dispersion stability but also enhance their adsorbability on the steel surface and embedded stability between the rubbing surfaces. Hence, CD--PEPMA as an additive showed outstanding rust resistance and tribological performance.

Disulfide-incorporated lipid prodrugs of cidofovir: Synthesis, antiviral activity, and release mechanism.

The double-stranded DNA (dsDNA) viruses represented by adenovirus and monkeypox virus, have attracted widespread attention due to their high infectivity. In 2022, the global outbreak of mpox (or monkeypox) has led to the declaration of a Public Health Emergency of International Concern. However, to date therapeutics approved for dsDNA virus infections remain limited and there are still no available treatments for some of these diseases.

Orthogonal dual reporter-based gain-of-signal assay for probing SARS-CoV-2 3CL protease activity in living cells: inhibitor identification and mutation investigation.

The main protease (3-chymotrypsin-like protease, 3CLpro) of SARS-CoV-2 has become a focus of anti-coronavirus research. Despite efforts, drug development targeting 3CLpro has been hampered by limitations in the currently available activity assays. Additionally, the emergence of 3CLpro mutations in circulating SARS-CoV-2 variants has raised concerns about potential resistance.

Design, Synthesis, and Biological Evaluation of Benzimidazole Derivatives as Potential Lassa Virus Inhibitors.

The Lassa virus (LASV) causes Lassa fever, a highly infectious and lethal agent of acute viral hemorrhagic fever. At present, there are still no effective treatments available, creating an urgent need to develop novel therapeutics. Some benzimidazole compounds targeting the arenavirus envelope glycoprotein complex (GPC) are promising inhibitors of LASV.

Corrosion inhibition mechanism of imidazole ionic liquids with high temperature in 20% HCl solution.

Background: This paper focuses on the chemical and physical adsorption of 1-hexyl-2,3-dimethyl imidazolium bromide (HDMIMBr), 1-decyl-2,3-dimethyl imidazolium bromide (DDMIMBr), and 1-hexadecyl-2,3-dimethyl imidazolium bromide (C16DMIMBr) on the surface of mild steel at high temperature in order to explore the mechanism of a corrosion inhibitor in a complex environment.

Methods: Gravimetric, scanning electron microscope, X-ray photoelectron spectroscopy, and electrochemical tests explored the corrosion inhibition performance from the experimental level. Quantum chemical calculations and molecular dynamics simulations reveal the corrosion inhibition mechanism from the molecular scale.

Spray-Dried Inhalable Powder Formulations of Gentamicin Designed for Pneumonic Plague Therapy in a Mouse Model.

Infection with Yersinia pestis () may cause pneumonic plague, which is inevitably fatal without treatment. Gentamicin (GM), an aminoglycoside antibiotic, is a drug commonly used in the treatment of plague. However, it requires repeated intramuscular or intravenous administration.

Synthesis of Eco-Friendly Carbon Dots as Self-Repairing Additives of Polyalphaolefin by Means of a Green Solvation Effect.

The eco-friendly menthol-modified carbon dots (CDs-Menth) were synthesized for the first time and exhibited the particularly promising application potential as additives of polyalphaolefin (PAO4). On the one hand, the CDs-Menth could be well dispersed into PAO4 with excellent and long-term dispersion stability via a convenient and green mean, that is, the solvation effect of petroleum ether. This mean was far more advanced to current strategies such as chemical modifications and adding dispersants.

High expression level of CXCL1/GROα is linked to advanced stage and worse survival in uterine cervical cancer and facilitates tumor cell malignant processes.

Background: CXCL1 belongs to a member of the ELR + CXC chemokine subgroups that also known as GRO-alpha. It has been recognized that several types of human cancers constitutively express CXCL1, which may serve as a crucial mediator involved in cancer development and metastasis via an autocrine and/or paracrine fashion. However, the expression pattern and clinical significance of CXCL1 in human uterine cervix cancer (UCC), as well as its roles and mechanisms in UCC tumor biology remains entirely unclear.

DNMT3A and DNMT3B in Breast Tumorigenesis and Potential Therapy.

Breast cancer has become a leading cause of cancer-related deaths in women worldwide. DNA methylation has been revealed to play an enormously important role in the development and progression of breast cancer. DNA methylation is regulated by DNA methyltransferases (DNMTs), including DNMT1, DNMT2, and DNMT3.

A label-free amperometric immunosensor with improved electrocatalytic 3D braided AuPtCu-SWCNTs@MoS-rGO for human growth differentiation factor-15 detection.

Growth differentiation factor-15 (GDF-15) is a member of the transforming growth factor-β family. GDF-15 is overexpressed in cardiovascular diseases and has become a novel biomarker for these diseases. In this study, we fabricated a label-free electrochemical immunosensor for sensitive detection of GDF-15.

Naphthoquine: A Potent Broad-Spectrum Anti-Coronavirus Drug In Vitro.

COVID-19 has spread around the world and caused serious public health and social problems. Although several vaccines have been authorized for emergency use, new effective antiviral drugs are still needed. Some repurposed drugs including Chloroquine, Hydroxychloroquine and Remdesivir were immediately used to treat COVID-19 after the pandemic.

Tribological properties of a series of carbon dots modified by ionic liquids with various anion species: experimental findings and density functional theory calculations.

A series of carbon dots modified by ionic liquids with various anion species (CDs-ILs-X) were facilely synthesized by a one-pot pyrolysis method and subsequent anion exchange processes, where X- represented the anions of hexafluorophosphate (PF6-), bis(trifluorosulfonyl) imide (NTf2-), bis(salicylato) borate (BScB-) and oleate (OL-). Their tribological properties as lubricant additives of polyethylene glycol (PEG200) were investigated under the ball-on-plate reciprocating mode and steel/steel contact. The maximum friction coefficient and wear volume reductions of PEG200 triggered by CDs-ILs-PF6, CDs-ILs-NTf2, CDs-ILs-BScB and CDs-ILs-OL were up to 42.

Ovarian microcystic stromal tumor with omental metastasis: the first case report and literature review.

Background: Microcystic stromal tumor (MCST) of the ovary is an extremely rare subtype of sex cord-stromal neoplasm first described by Irving and Young in 2009. Tumors from all previously reported cases (fewer than 40 total) were benign, but one was a case of ovarian MCST that reoccurred.

Case Presentation: Herein, we present a unique single case of ovarian MCST with omental metastasis in a 47-year-old Chinese female along with its histologic and immunohistochemical profile and genetic alterations.

Association between -511C/T polymorphism and Behçet's disease: a meta-analysis.

Background: Many studies have investigated the relationship between the interleukin-1β gene () -511C/T polymorphism and the risk of Behçet's disease (BD); however, the conclusions remain controversial.

Methods: In this study, we systemically retrieved relevant studies from the Chinese Biomedicine Database, China National Knowledge Infrastructure, Embase, Cochrane Library, and PubMed databases. We then calculated the odds ratios (ORs) and 95% confidence intervals (CIs) using the meta-package Stata version 12.