Continuous topical irrigation for severely infected wound healing.

Background: Management of severely infected wounds is a formidable challenge. The pilot prospective cohort study is to investigate the influence of continuous topical irrigation (CTI) on the outcomes of severely infected wounds.

Methods: This pilot study was performed on 17 patients with a single severely infected wound treated with CTI, compared with a control group of 15 patients treated with standard of care from January 2011-January 2013.

Triptolide ameliorates colonic fibrosis in an experimental rat model.

Triptolide is known to exert anti-inflammatory and immunomodulatory activities; however, its impact on intestinal fibrosis has not been previously examined. Based on our previous studies of the suppressive activity of triptolide on human colonic subepithelial myofibroblasts and the therapeutic efficacy of triptolide in Crohn's disease, it was hypothesized that triptolide may have beneficial effects on intestinal fibrosis. In the present study, colonic fibrosis was induced in rats by 6 weekly repeated administration with a low-dose of 2,4,6-trinitrobenzene sulfonic acid (TNBS) and was then treated with triptolide or PBS daily (control) simultaneously.

VAWCM-Instillation Improves Delayed Primary Fascial Closure of Open Septic Abdomen.

Background. Failure to achieve delayed primary fascial closure (DPFC) is one of the main complications of open abdomen (OA), certainly when abdominal sepsis is present. This retrospective cohort study aims to evaluate the effect of combined therapy of vacuum-assisted mesh-mediated fascial traction and topical instillation (VAWCM-instillation) on DPFC in the open septic abdomen.

Vitamin D prevents the intestinal fibrosis via induction of vitamin D receptor and inhibition of transforming growth factor-beta1/Smad3 pathway.

Background And Aims: Vitamin D deficiency in patients with inflammatory bowel disease (IBD) is associated with greater disease activity and lower quality of life. Intestinal fibrosis is a main complication of IBD. However, the effect of vitamin D on intestinal fibrosis remains unclear.