Deep learning model for automated diagnosis of moyamoya disease based on magnetic resonance angiography.

Background: This study explores the potential of the deep learning-based convolutional neural network (CNN) to automatically recognize MMD using MRA images from atherosclerotic disease (ASD) and normal control (NC).

Methods: In this retrospective study in China, 600 participants (200 MMD, 200 ASD and 200 NC) were collected from one institution as an internal dataset for training and 60 from another institution were collected as external testing set for validation. All participants were divided into training (N = 450) and validation sets (N = 90), internal testing set (N = 60), and external testing set (N = 60).

StAP1 phage: an effective tool for treating methicillin-resistant infections.

Introduction: infection has long been a serious concern in the medical field, with methicillin-resistant (MRSA) posing a considerable challenge to public health. Given the escalating bacterial resistance and the favorable biosafety and environmental properties of phages, the resurgence of phage therapy offers a promising alternative to antibiotics.

Methods: In this study, we isolated and characterized a MRSA phage named StAP1 from a Chinese hospital.

[Application of health failure mode and effect analysis for the airbag pressure management of patients with artificial airways].

Objective: To analyze the application effect of health failure mode and effect analysis (HFMEA) model in patients with artificial airways in the cardiovascular surgery intensive care unit (CSICU) by establishing a HFMEA project team, and to develop targeted improvement measures and processes.

Methods: The patients undergoing cardiovascular surgeries and with established artificial airways in the Shandong Provincial Hospital Affiliated to Shandong First Medical University were recruited from October 2021 to March 2022. The enrolled patients were divided into the conventional management group and the HFMEA model management group according to random number table method.

Prone positioning in extubated patients with hypoxemic respiratory failure after cardiac surgery: A retrospective study.

Background: Hypoxemic respiratory failure is a serious complication that can occur at any stage after cardiac surgery. Prone positioning (PP) is safe and effective for patients receiving invasive ventilation after hypoxemic respiratory failure; however, few related studies have focused on its use with extubated cardiac surgery patients. Researchers recently reported beneficial effects of PP for hypoxemic patients with COVID-19 and those with moderate ARDS (acute respiratory distress syndrome,ARDS).

Integrated mRNA-seq and miRNA-seq analysis of goat fibroblasts response to strain M5-90.

Brucellosis is a globally zoonotic bacterial disease of humans and various animals including goats, sheep, and cattle. M5-90, a live attenuated vaccine strain, has been widely used to prevent brucellosis in goats and sheep. However, the molecular mechanisms governing protective immunity response in non-professional phagocytes infected with M5-90 have not been fully investigated, especially in goats.

Impact of a sleep promotion protocol on off-pump coronary artery bypass graft patients.

Background: Sleep abnormalities frequently occur in intensive care unit (ICU) patients, and the consequences of sleep abnormalities in patients who undergo off-pump coronary artery bypass graft (OPCABG) surgery are particularly significant. Although many interventions have been reported to improve sleep, few sleep promotion protocols have been designed specifically for patients in cardiac ICUs.

Aims And Objectives: This study aimed to explore the effects of an evidence-based sleep promotion protocol on patients who underwent OPCABG in a cardiac ICU.

miR-146b-5p Plays a Critical Role in the Regulation of Autophagy in ∆per -Infected RAW264.7 Cells.

-caused brucellosis is one of the most widespread worldwide zoonoses. Lipopolysaccharide (LPS) of , which functions as pathogen-associated molecular patterns (PAMPs), is an important virulence factor that elicits protective antibodies. of .

Integrated mRNA and miRNA profiling in NIH/3T3 cells in response to bovine papillomavirus gene expression.

Delta bovine papillomaviruses (δBPVs) mainly infect cattle and cause fibropapillomas. δBPVs encode three oncogenes, , and . The effect of on microRNA (miRNA) and mRNA expression profiles is not well characterized.

Enhanced luminescence properties of InAs nanowires via organic and inorganic sulfide passivation.

InAs nanowires (NWs) have been considered to be highly suitable for future nanoscale photonic applications in mid-wave infrared region. However, progress in this area has been seriously hampered because of the poor radiative efficiency of InAs NWs attributed to their non-radiative (NR) surface. Herein, we demonstrated that a significant improvement of optical performances of InAs NWs grown by chemical vapor deposition could be achieved via sulfur passivation process.

Genome-wide analysis of circular RNAs in goat skin fibroblast cells in response to Orf virus infection.

Orf, caused by Orf virus (ORFV), is a globally distributed zoonotic disease responsible for serious economic losses in the agricultural sector. However, the mechanism underlying ORFV infection remains largely unknown. Circular RNAs (circRNAs), a novel type of endogenous non-coding RNAs, play important roles in various pathological processes but their involvement in ORFV infection and host response is unclear.

Alterations of microRNAs and their predicted targeting mRNAs expression in RAW264.7 macrophages infected with Omp25 mutant Brucella melitensis.

Brucellosis is a worldwide zoonosis caused by Brucella species and represents a serious threat to both human and animal health. Omp25 is an important immunogenic and protective antigen in Brucella species; however, the functional mechanism of Omp25 in macrophages has not yet been elucidated. Here, we constructed a Brucella melitensis omp25 deletion mutant (M5-90-Δ omp25) and performed microRNA (miRNA) profiling of infected RAW264.

Upregulation of Immune Process-Associated Genes in RAW264.7 Macrophage Cells in Response to Infection.

Melioidosis is a severe and fatal tropical zoonosis, which is triggered by . To better understand the host's response to infection of , an RNA-Seq technology was used to confirm differentially expressed genes (DEGs) in RAW264.7 cells infected with .