Publications by authors named "BaoJing Wang"
By genome-wide association studies, the gene has been shown to affect multiple, apparently unrelated inherited traits, including bone density and body mass index. Therefore, it is considered a potentially pleiotropic gene. In this study, we identified a 12 bp deletion variant (NC_030814.
View Article and Find Full Text PDFBackground: The objective of this study was to evaluate the impact of pharmaceutical care on the knowledge, adherence, and efficacy of hormone therapy in climacteric women participated in multidisciplinary collaborative clinic, launched by Peking University First Hospital (Beijing, People's Republic of China) in 2012.
Methods: A total of 296 patients were recruited (intervention group n=150, control group n=146). The patients in the intervention group visited the multidisciplinary collaborative clinic for their initial hormone therapy, receiving individualized pharmaceutical care (PC), whereas the control group visited only the general clinic without PC.
CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats) mediated genome editing is a powerful approach for loss of function studies. Here we report that lentiviral CRISPR/Cas9 vectors are highly efficient in introducing mutations in the precursor miRNA sequence, thus leading to the loss of miRNA expression and function. We constructed four different lentiviral CRISPR/Cas9 vectors that target different regions of the precursor miR-21 sequence and found that these lentiviral CRISPR/Cas9 miR-21 gRNA vectors induced mutations in the precursor sequences as shown by DNA surveyor mutation assay and Sanger sequencing.
View Article and Find Full Text PDF[Establishment of reference ranges for thyroid-related indicators in normal pregnant women].
Zhonghua Yi Xue Za Zhi
February 2016
Article Synopsis
- The study aimed to establish specific reference ranges for thyroid-related indicators in pregnant women, focusing on serum TSH levels during the first trimester.
- A total of 548 first-trimester pregnant women were analyzed, and the research measured levels of TSH, total thyroxine (TT4), free thyroxine (FT4), and urine iodine (UI) across different trimesters using specific detection kits.
- Results showed different reference ranges for TSH, TT4, and FT4 during each trimester, highlighting the importance of tailored reference values for pregnant women rather than relying solely on standard kits.
Objective: To assess the safety, efficacy, predictability, stability, and changes in cylindrical degree and axis after iris recognize-guided LASIK with the Zyoptix 4.01 System for the correction of myopic astigmatism.
Methods: The present study was a prospective, nonrandomized, self-controlled trial.