Publications by authors named "Bao-wen Qi"
Article Synopsis
- Patients with diabetes are more susceptible to myocardial ischemia/reperfusion injury (MI/RI), and Shuxin decoction (SXT), a modified herbal formula, has shown promise in reducing this risk in clinical settings, though its mechanisms are not fully understood.
- The study aims to explore how SXT mitigates MI/RI in diabetic patients using an ensemble model that combines network pharmacology and biology, identifying key components and therapeutic targets associated with the condition.
- Results indicate that SXT may improve lipid metabolism and reduce apoptosis in MI/RI by decreasing oxidized LDL levels and targeting the RAGE signaling pathway, with animal trials supporting these findings through observed reductions in harmful substances and regulation of blood lipid levels.
Background: To investigate the burden of thyroid cancer and its attributable risk factors in 204 countries and territories during 30 years.
Methods: We extracted data from the Global Burden of Disease (GBD) 2019 database, including incidence, mortality, disability-adjusted life-years (DALYs), and the attributable risk factors of thyroid cancer from 1990 to 2019. Estimated annual percentage changes (EAPC) were calculated to assess the changes in age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR), and age-standardized DALYs rate (ASDR).
A phosphoinositide 3-kinase-gamma inhibitor, AS605240 prevents bleomycin-induced pulmonary fibrosis in rats.
Biochem Biophys Res Commun
June 2010
Phosphoinositide 3-kinase-gamma (PI3Kgamma) has been identified to play the critical roles in inflammatory cells activation and recruitment in multiply inflammatory diseases and it promised to be a prospective target for relevant inflammatory diseases therapy. AS605240, a selective PI3Kgamma inhibitor, has been proved effective on several inflammatory diseases. In this study, we investigated the protective effect of AS605240 on bleomycin-induced pulmonary fibrosis in rats.
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