[Changes in Ozone Pollution Trend Characteristics and Sensitivity in Jinan from 2015 to 2020].

The surface ozone (O) spatiotemporal distribution, variations, and its causes in Ji'nan from 2015 to 2020 were revealed based on the air quality monitoring network data and satellite retrievals from the Ozone Monitoring Instrument (OMI). The results showed that the ozone concentration in Ji'nan gradually increased from 2015 to 2020. The annual 90 percentile of the daily maximum 8-h average (MDA8) O(namely the annual evaluation value) and the MDA8 O(April-September) increased by 4.

Combined effects of prenatal phthalate exposure on cardiometabolic risk score among 4- to 7-year-old children: MABC study.

There is currently no consensus about the impact of prenatal phthalate exposure on blood pressure and glycolipids in children. Few studies consider the health effects as an integrated indicator. The combined effect of multiple phthalate exposures is often ignored.

Matrine induces hepatocellular carcinoma apoptosis and represses EMT and stemness through microRNA-299-3p/PGAM1 axis.

This study explored the impacts of matrine on hepatocellular carcinoma (HCC) cell growth, metastasis, epithelial-mesenchymal transition (EMT), and stemness through regulating the microRNA / () axis. The association between expression with the prognosis of HCC patients was studied. and sequences were transfected into matrine-treated HCC cells, and cell proliferation, invasion, apoptosis, and stemness were detected, as well as protein expression of EMT- and stemness-related makers.

Evaluation of high-risk factors and the diagnostic value of alpha-fetoprotein in the stratification of primary liver cancer.

Background: Alpha-fetoprotein (AFP) is one of the diagnostic standards for primary liver cancer (PLC); however, AFP exhibits insufficient sensitivity and specificity for diagnosing PLC.

Aim: To evaluate the effects of high-risk factors and the diagnostic value of AFP in stratified PLC.

Methods: In total, 289 PLC cases from 2013 to 2019 were selected for analysis.

Impacts of Mercury Exposure Levels and Sources on the Demethylation of Methylmercury Through Human Gut Microbiota.

This study aims to investigate methylmercury (MeHg) demethylation processes in human gut. Here, we determined the compositions and MeHg demethylation rates of gut microbiota in residents from different Hg exposure levels (Wanshan (WS) town and Yangtou (YT) town) and different Hg exposure sources (Zhuchang (ZC) town and YT town) regions. MeHg and inorganic Hg exposure levels in residents of WS town were significantly higher than those of YT and ZC town.

Laparoscopic Glissonian pedicle versus hilar dissection approach hemihepatectomy: A prospective, randomized controlled trial.

Background/purpose: This over 7-year case study is the first to compare the results of laparoscopic Glissonian pedicle approach hemihepatectomy (LGAH) and laparoscopic hilar dissection approach hemihepatectomy (LHAH) in a randomized controlled trial (RCT).

Methods: Patients who had undergone laparoscopic hemihepatectomy, either LGAH or LHAH, between March 2012 and December 2019 at our center were prospectively enrolled and assigned to the LGAH or LHAH group. Both groups were stratified and compared, and the preoperative and follow-up outcomes were analyzed.

RCN1 induces sorafenib resistance and malignancy in hepatocellular carcinoma by activating c-MYC signaling via the IRE1α-XBP1s pathway.

The increasing incidence of hepatocellular carcinoma (HCC) is of great concern globally, but the molecular pathogenesis of these tumors remains unclear. Sorafenib is a first-line drug for the treatment of advanced HCC. However, the efficacy of sorafenib in improving patient survival is limited, and most patients inevitably develop resistance to this drug.

Synthesis and Biological Evaluation of Celastrol Derivatives with Improved Cytotoxic Selectivity and Antitumor Activities.

Cdc37 associates kinase clients to Hsp90 and promotes the development of cancers. Celastrol, a natural friedelane triterpenoid, can disrupt the Hsp90-Cdc37 interaction to provide antitumor effects. In this study, 31 new celastrol derivatives, -, -, and -, were designed and synthesized, and their Hsp90-Cdc37 disruption activities and antiproliferative activities against cancer cells were evaluated.

Optimization of -Phenylpropenoyl-l-amino Acids as Potent and Selective Inducible Nitric Oxide Synthase Inhibitors for Parkinson's Disease.

-Phenylpropenoyl-l-amino acids (NPAs) are inducible nitric oxide synthase (iNOS) inhibitors possessing preventive effects for Parkinson's disease (PD). Here, structural modifications for improving the iNOS inhibitory activity and blood-brain barrier (BBB) permeability of NPAs were conducted, leading to 20 optimized NPA derivatives (). Compound , with the most potent activity (IC = 74 nM), high BBB permeability ( = 19.

Origin of Magnetic Relaxation Barriers in a Family of Cobalt(II)-Radical Single-Chain Magnets: Density Functional Theory and Calculations.

Density functional theory (DFT) and calculations were performed to probe the origin of the magnetic relaxation barriers for two finite single-chain magnets (SCMs) featuring a one-dimension chain, Co(hfac)(R-NapNIT) (R-NapNIT = 2-(2'-(-)naphthyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, R = MeO () or EtO ()). Our calculations show that the strong intrachain Co-Co exchange coupling interactions transmitted by radicals can contribute much more than ionic anisotropy to the height of the reversal barrier of magnetization for the single-chain magnets (SCMs) with |2| < |4/3|. In addition, the anisotropic energy barrier Δ decreases with the decrease of |2/| ratio and finally vanishes in the limit of broad domain walls (|2| < < |4 /3|).

Why lanthanide Er SIMs cannot possess huge energy barriers: a theoretical investigation.

Complete active space self-consistent field (CASSCF) combined with restricted active space spin interaction with spin-orbit coupling (RASSI-SO) was used to probe why single-ion magnets (SIMs) composed of the "prolate" lanthanide ion ErIII cannot possess huge energy barriers. According to the proposal by Long et al., equatorially coordinated ligand environments are preferable for "prolate" lanthanide ions to have large energy barriers.

Comparison of long-term oncologic outcomes laparoscopy-assisted gastrectomy and open gastrectomy for gastric cancer.

Purpose: Laparoscopy-assisted gastrectomy (LAG) is proven by considerable studies as a safe procedure for early gastric cancer (EGC), but its long-term oncologic outcomes in advanced gastric cancer (AGC) have not been well-described. This study aimed at verifying the non-inferiority of LAG in the treatment of EGC and comparing the oncological feasibility of LAG and open gastrectomy (OG) for AGC.

Methods: A total of 209 consecutive patients who underwent LAG or OG with D2 lymph node dissection between December 2008 and November 2012 were included.

Single-Molecule Magnetism in Three Dy Complexes from the Use of a Pentadentate Schiff Base Ligand and Different Benzoates.

Three dinuclear dysprosium(III) complexes, [Dy L (O CPh) ]⋅2 MeOH (1), [Dy L {(2-NO )O CPh} ] (2), and [Dy L {(2-OH)O CPh} ]⋅MeOH⋅MeCN (3) (H L=N ,N -bis(4-chlorosalicyladehyde)diethylenetriamine), have been synthesized and structurally characterized. Complexes 1-3 possess similar Ln cores and differ in substituents at the benzyl rings of benzoates. Direct current (dc) magnetic susceptibility studies in the 2-300 K range showed weak antiferromagnetic interactions between two dysprosium(III) ions in 1-3.

A family of lanthanide complexes with a bis-tridentate nitronyl nitroxide radical: syntheses, structures and magnetic properties.

Eleven new lanthanide complexes based on a bis-tridentate nitronyl nitroxide radical NIT-Pm2Py (2-(4,6-di(pyridin-2-yl)pyrimidin-2-yl)-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazol-1-oxy-3-oxide), namely (NIT-Pm2Py)Ln(hfac) (Ln = Gd (1), Tb (2), Dy (3), Ho (4), Er (5), Yb (6)), [(NIT-Pm2Py)Ln(hfac)]·xHO (Ln = Gd (7), Tb (8), Ho (10), x = 0.5 for 7 and 1 for 8 and 10) and (NIT-Pm2Py)Ln(hfac) (Ln = Dy (9), Er (11)) were prepared and characterized. These complexes can be selectively prepared by controlling the reaction ratio of Ln(hfac)·2HO to the radical ligand NIT-Pm2Py.

Field-Induced Single-Ion Magnetic Behavior in Two Mononuclear Cobalt(II) Complexes.

The employment of a new rigid N-tridentate ligand, bis(1-chloroimidazo[1,5-a]pyridin-3-yl)pyridine (bcpp), in the construction of cobalt(II) single-ion magnets is reported. Two cobalt(II) complexes, [Co(bcpp)Cl ] (1) and [Co(bcpp)Br ] (2), have been prepared and characterized. Single-crystal XRD analyses reveal that complexes 1 and 2 are isostructural.

Synthesis, Structures, and Single-Molecule Magnetic Properties of Three Dy Complexes.

To explore the influences of the subtle structural variations in the ligand backbones on the single-molecule magnetic properties of dinuclear dysprosium(III) complexes, three ligands-H L (H L =N ,N -bis(salicylaldehyde)diethylenetriamine), H L (H L =N ,N -bis(3-methoxysalicylidene)diethylenetriamine), and H L (H L =N ,N -bis(5-chlorosalicyladehyde)diethylenetriamine)-were synthesized and employed to prepare the expected dinuclear dysprosium(III) complexes. The three ligands differ in terms of the substituents at the benzene rings of the salicylaldehyde moieties. The reactions of Dy(NO ) ⋅6 H O, pivalic acid, and the ligands H L , H L , and H L generated complexes with the formulae [Dy (L ) (piv) ] (1), [Dy (L ) (piv) ] (2), and [Dy (L ) (piv) ]⋅ 2 MeCN (3), respectively.

Effect of Bridging Ligands on Magnetic Behavior in Dinuclear Dysprosium Cores Supported by Polyoxometalates.

A family of dinuclear dysprosium cores bridged by different ligands within a polyoxometalates (POMs) framework, (TBA)H[(PWO)DyX(HO)]·6HO (X = OH (1), F (2), OAc (3); TBA = tetra- n-butylammonium), was successfully synthesized and structurally characterized. Magnetic studies indicate that the bridging ligands can significantly affect the magnetic behaviors, with 1 and 3 showing antiferromagnetic coupling and 2 bridged by fluoride ions showing ferromagnetic interaction. 1 and 2 behaved as single-molecule magnets (SMMs) with the thermally activated energy barrier of 98(5) and 74(6) cm under zero dc filed, respectively, whereas no SMM behavior was observed for 3 bridged by two μ-η:η-acetato ligands.

Reversible on-off switching of both spin crossover and single-molecule magnet behaviours a crystal-to-crystal transformation.

The on-off switching of spin-crossover (SCO) and single-molecule magnetism (SMM) remains highly attractive, especially if it involves dynamic crystal-to-crystal transformation. Herein we report the first molecule, a mononuclear cobalt(ii) complex, that exhibits on-off switching between SCO and SMM reversibly during crystal-to-crystal transformation. Subtle structural transformation triggered by a simple dehydration-rehydration process induces significant geometrical changes of the Co center and modification of the supramolecular interactions and switches its colour and magnetic properties (dark red/SCO-on/SMM-off ↔ orange/SCO-off/SMM-on).

Atropisomeric meroterpenoids with rare triketone-phloroglucinol-terpene hybrids from Baeckea frutescens.

Baefrutones A-F (1-6), six new meroterpenoids with rare triketone-phloroglucinol-monoterpene/sesquiterpene frameworks, together with their biosynthetically related intermediate (±)-baeckenon B (7), were isolated from the aerial part of Baeckea frutescens under the guidance of HPLC-Q/TOF-MS2 investigation. Compounds 1-4 represent the first examples of natural meroterpenoids existing as four pairs of inseparable diastereomeric atropisomers (2 : 1, 1H NMR integration) caused by the restricted rotation around the C-6-C-7-C-1' bonds arising from the intramolecular hydrogen bond between C-1 carbonyl and 2'-OH. The discovery of these architectures not only largely enriched the chemodiversity of the meroterpenoid and atropisomer library, but also might be exciting and challenging for asymmetric organic synthesis.

Consecutive one-/two-step relaxation transformations of single-molecule magnets via coupling dinuclear dysprosium compounds with chloride bridges.

The double chloride-bridged dimer of a dinuclear dysprosium(iii) single-molecule magnet (SMM) was successfully isolated by assembling centrosymmetric dinuclear Dy2 SMMs. Such structural transformation involves the generation and cleavage of chloride bridges and leads to consecutive transformations of one- and two-step slow relaxation of magnetization.

Modulating the Magnetic Interaction in New Triple-Decker Dysprosium(III) Single-Molecule Magnets.

A new type of dinuclear dysprosium(III) complex based on phthalocyanine and salicylaldehyde derivatives (HL-R), [Dy(Pc)(L-R)(HO)]·2THF (R = OCH (1), OCH (2); HPc = phthalocyanine; HL-OCH = 2-hydroxy-3-methoxybenzaldehyde; HL-OCH = 3-ethoxy-2-hydroxybenzaldehyde), was successfully synthesized and structurally characterized. Complex 1 features a sandwich-type triple-decker structure, where two coplanar L-OCH ligands lie in the middle layer shared by two eight-coordinated Dy ions and two Pc ligands are located in the outer layer. In 2, the introduction of an ethoxy group generates a noncoordination mode for the O atom.

[Development in synthesis of andrographolide derivatives].

Andrographolide is one of the major natural active constituents in Andrographis panniculata of Acanthaceae family. Andrographolide and its derivatives are proved to posses a wide range of biological activities, such as anti-inflammatory, antiviral, anti-tumor, anti-human immunodeficiency virus(HIV), hepatoprotective and α-glucosidase inhibition activity. In this paper, the development of synthesis of rographolide derivatives and their related pharmacological activities were reviewed.