Publications by authors named "Bao-Yuan Huang"
Background: Macrophages play a pivotal role in the development and recovery of acute lung injury (ALI), wherein their phenotypic differentiation and metabolic programming are orchestrated by mitochondria. Specifically, the mitochondrial calcium uniporter (MCU) regulates mitochondrial Ca (Ca) uptake and may bridge the metabolic reprogramming and functional regulation of immune cells. However, the precise mechanism on macrophages remains elusive.
View Article and Find Full Text PDFRestoring immune balance by targeting macrophage polarization is a potentially valuable therapeutic strategy for ulcerative colitis (UC). Dioscin is a steroidal saponin with potent anti-inflammatory, immunoregulatory, and hypolipidemic effects. This study examined the protective effect of Dioscin on UC in mice and explored the underlying mechanisms.
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- The study investigates how uncaria alkaloids, particularly Icory, can counteract cancer multidrug resistance (MDR) caused by ABC transporters, which often leads to chemotherapy failure.
- Icory was found to enhance the effectiveness of various chemotherapy drugs—like doxorubicin, vincristine, and paclitaxel—specifically in cancer cells overexpressing the ABCB1 transporter, while not affecting cells reliant on other transporters like ABCC1 or ABCG2.
- Mechanistically, Icory increased the accumulation of doxorubicin in these resistant cells by blocking ABCB1’s efflux function, suggesting that it could be developed as a targeted agent to improve cancer treatment outcomes in patients with
Article Synopsis
- * Findings indicated that the overall prevalence was 0.1% for CL/P and 0.04% for CP, with higher risks associated with factors like multiple pregnancies, lower gestational ages (≤37 weeks), and low birth weights (<1.5 kg).
- * The researchers emphasized the importance of increasing awareness and early identification of at-risk newborns and mothers to mitigate long-term effects on speech and language development related to these deformities.
Ultraviolet and HNO2 were selected as the mutagens to perform the single factor and multi-factor induction mutation towards Candida utilis CR-001. Six mutant strains which possessed high heavy metal removal efficiency and high resistance to Cr6+ were obtained through combined induction with UV and HNO2. After they were subcultured for 10 generations, the diameter of bacteriostatic circle of CRC2811-1 and CRC7-2 was reduced to 1.
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