Association of serum biomarkers with early neurologic improvement after intravenous thrombolysis in ischemic stroke.

Background: Early neurologic improvement (ENI) after intravenous thrombolysis is associated with favorable outcome, but associated serum biomarkers were not fully determined. We aimed to investigate the issue based on a prospective cohort.

Methods: In INTRECIS study, five centers were designed to consecutively collect blood sample from enrolled patients.

Change of Serum Biomarkers to Post-Thrombolytic Symptomatic Intracranial Hemorrhage in Stroke.

Background: Symptomatic intracranial hemorrhage (sICH) is a terrible complication after intravenous alteplase in stroke, and numerous biomarkers have been investigated. However, the change of biomarkers to sICH has not been well determined.

Aim: To investigate the association between the change of biomarkers and sICH.

Association of Serum Biomarkers With Post-Thrombolytic Symptomatic Intracranial Hemorrhage in Stroke: A Comprehensive Protein Microarray Analysis From INTRECIS Study.

Background: Symptomatic intracranial hemorrhage (sICH) after intravenous thrombolysis is closely related to the poor outcome of stroke.

Aims: To determine the serum biomarkers associated with sICH based on the INTRECIS study.

Methods: Enrolled patients with sICH and without any ICH were matched by propensity score matching with the ratio of 1:1.