Publications by authors named "Bao-Yan Xu"
Background: Blonanserin (BNS) is a well-tolerated and effective drug for treating schizophrenia.
Aim: To investigate which types of patients would obtain the most benefit from BNS treatment.
Methods: A total of 3306 participants were evaluated in a 12-week, prospective, multicenter, open-label post-marketing surveillance study of BNS.
Objectives: To investigate the relationship between systemic inflammatory response and short-term mortality in patients with non-cirrhotic chronic severe hepatitis (CSH) by using several indicators of inflammation including neutrophil-to-lymphocyte ratio (NLR), neutrophil (NEU), white blood cell (WBC), platelet-to lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR).
Methods: Data were collected from two prospectively enrolled CATCH-LIFE noncirrhotic cohorts. Cox regression analysis was used to investigate the association between systemic inflammatory biomarkers and 90-day liver transplant (LT)-free mortality.
Hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF) is a complicated syndrome with extremely high short-term mortality. Whether plasma exchange (PE) improves HBV-ACLF outcomes remains controversial. Here, PE-based non-bioartificial liver support system (NB-ALSS) effects on short-term HBV-ACLF patient outcomes were investigated.
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- * Seventy patients were divided into two groups, with one group receiving only escitalopram and the other group receiving both escitalopram and HBO, and their progress was monitored using specific assessment scales over six weeks.
- * Results indicated that while both treatments improved depression scores initially, only the combination treatment showed significant improvement in cognitive function after four and six weeks, suggesting that HBO can enhance the effects of escitalopram.
Prevalence and Clinical Significance of Portal Vein Thrombosis in Patients With Cirrhosis and Acute Decompensation.
Clin Gastroenterol Hepatol
October 2020
Article Synopsis
- Portal vein thrombosis (PVT) is a serious issue in cirrhosis patients and is more common in those experiencing acute decompensation (AD), with a prevalence of 9.36% compared to 5.24% in those without AD.
- Recent PVT was found in 63.37% of patients with cirrhosis and AD, and these patients also had higher rates of variceal bleeding and elevated D-dimer levels.
- Despite the higher incidence of bleeding and complications, the one-year mortality rate was similar between patients with and without PVT, highlighting the need for preventive measures and regular screenings in vulnerable cirrhosis patients.
It was reported that antituberculosis medicines could induce liver damage via oxidative stress. In this study, we investigated the effects of rifampicin (RFP) on the membrane expression of multidrug resistance-associated protein 2 (MRP2) and the relationship between oxidative stress and RFP-induced endocytosis of MRP2 in HepG2 cells. We found that RFP (12.
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- Definitions of acute-on-chronic liver failure (ACLF) differ between Western and Eastern perspectives, with alcoholism and hepatitis B virus (HBV) being the primary causes in their respective regions.
- A multicenter study in Asia is proposed to establish unified diagnostic criteria and treatment plans for ACLF, given the high prevalence of HBV in the region.
- The study aims to enroll 2,600 patients from 14 liver centers in China, tracking data and outcomes over a 36-month period for those with chronic liver disease and acute complications.
Genome-wide microarray-based analysis of miRNAs expression in patients with acute-on-chronic liver failure.
Hepatobiliary Pancreat Dis Int
February 2014
Background: Acute-on-chronic liver failure (ACLF) is a severe clinical syndrome that may cause a high mortality. However, the mechanism is still not clear. Characterization of the microRNA (miRNA) profiles in ACLF patients may provide new clues to the pathogenesis and management of this syndrome.
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- - The study investigates how the androgen receptor (AR) pathway may affect chronic hepatitis B (CHB) and acute liver failure (ALF) in males, focusing on the impact of a specific genetic variation (CAG repeat) in the AR gene.
- - Researchers analyzed 378 male CHB patients with ALF and 441 asymptomatic HBV carriers, finding that higher CAG repeat numbers significantly increased the risk of ALF and that testosterone levels varied during hepatitis flare and liver failure phases.
- - The results indicate that while serum testosterone levels were higher during hepatitis flare, they dropped sharply during ALF, and that men with the CAG variant had lower testosterone levels, linking genetic factors to susceptibility to HBV-related liver
Aim: Acute-on-chronic pre-liver failure (pre-ACLF) is defined as a severe acute episode of chronic hepatitis B characterized by serum bilirubin of 171 µmol/L or more, alanine aminotransferase of five times or more the upper limit of normal and prothrombin activity of more than 40%, having a potential for progression to acute-on-chronic liver failure (ACLF). This study is to evaluate the efficacy of short-term dexamethasone in pre-ACLF.
Methods: One hundred and seventy patients were assigned to dexamethasone therapy and control group at a ratio of 1:2.
Objective: To analyse the difference of genome-wide DNA methylation status of CpG island between the monozygotic twins with disconcordant phenotype of HBV infection and to discover possible differentially methylated genes.
Methods: Modified AIMS (amplification of inter-methylated sites) method was adopted. According to the frequent sites of CpG islands (-CGCG- and -CCGG-), three groups of isochizomers with distinct methylation sensitivity (Sma I-Xma I, Hpa II-Msp I and BssH II-Pau I/BseP I) were used to modify the AIMS method.
[The amplification and high efficient cloning of the whole genome sequence of hepatitis B virus].
Zhonghua Gan Zang Bing Za Zhi
September 2005
Objective: The primary comparative analysis between the host genetic factors and their relationships with clinical phenotype of 20 pairs of HBV infected and high risk twins.
Methods: Zygosity of twins was diagnosed by STR microsatellite polymorphism analysis. To identify the serological model and exclude the evidence of coinfection with other virus, we detected HAV, HBV, HCV, HDV, HEV serological markers by electrochemiluminescence method.