Incorporation of a Binuclear Cobalt Complex into MOFs for Photocatalytic CO Reduction with HO as an Electron Donor.

The development of molecular composite photocatalysts for cost-effective, sacrificial-reagent-free CO reduction is desirable but challenging. Herein, we employed an encapsulation strategy to encapsulate the binuclear cobalt complex (CoL) within NH-MIL-125 and synthesized a range of MOF-based composites with varying cobalt content for photocatalytic CO reduction. The photocatalytic results showed that the catalytic performance increased with the increase in CoL content, reaching a rapid CO generation rate of 27.

Research on the Construction of a Series of Transition Metal-Substituted Keggin-Type TMSPOMs@PCN-224 Composites through the Encapsulation Method and Their Electron Transfer Mechanism in CORR.

In order to take advantage of the distinct reversible multielectron transfer properties of polyoxometalates (POMs) and increase the electron density at the active sites during the electrochemical reduction of CO (CORR), a range of transition metal-doped polyoxometalates (TMSPOMs) was entrapped within the porphyrin-based framework of PCN-224 an encapsulation method, known as TMSPOMs@PCN-224 (TMSPOMs = [XWOM(HO)], [XWOV], M = Co, Mn; X = Si, = 6; X = P, = 5). The central elements (Si, P) and the incorporated transition metals (V, Co, and Mn) both play a role in adjusting the electronic structure and electron transfer during the CORR process. Remarkably, the composite material with cobalt substitution displayed significantly improved performance.

Green preparation of CaO-based CO adsorbent by calcium-induced hydrogenation of shell wastes at room/moderate temperature.

Capturing CO using clamshell/eggshell-derived CaO adsorbent can not only reduce carbon emissions but also alleviate the impact of trash on the environment. However, organic acid was usually used, high-temperature calcination was often performed, and CO was inevitably released during preparing CaO adsorbents from shell wastes. In this work, CaO-based CO adsorbent was greenly prepared by calcium-induced hydrogenation of clamshell and eggshell wastes in one pot at room/moderate temperature.

Exploring the role of sandwich-type polyoxometalates in {K(PWO)M(HO)}@PCN-222 (M = Mn, Ni, Zn) for electroreduction of CO to CO.

To overcome the drawbacks of high solubility and instability of polyoxometalates (POMs) in aqueous solution and to expand their application in the electrocatalytic reduction of CO (ECR), we assemble sandwich-type POMs, K[(PWO)M(HO)] (M = Mn, Ni, Zn, shortened as PWM), into the hexagonal channel of a porphyrin-based metal-organic framework (MOF) PCN-222 to form PWM@PCN-222 composites. Their ECR behavior displays polyoxoanion-dependent activity. PWMn@PCN-222 demonstrates a faradaic efficiency of 72.

One-pot preparation of H-mixed CH fuel and CaO-based CO sorbent by the hydrogenation of waste clamshell/eggshell at room temperature.

The preparation of clean fuel or CO adsorbents using industrial and domestic garbage is an alternative way of meeting global energy needs and alleviating environmental problems. Herein, H-mixed CH fuel and CaO-based CO sorbent were first prepared in one pot by the mechanochemical reaction of pretreated clamshell or eggshell wastes (carbon and calcium source) with calcium hydride (hydrogen source) at room temperature. In the above reactions, CH was the sole hydrocarbon product, and its yield reached 78.

The PARP1 Inhibitor Niraparib Represses DNA Damage Repair and Synergizes with Temozolomide for Antimyeloma Effects.

Purpose: Poly(ADP-ribose) polymerase 1 (PARP1) is necessary for single-strand break (SSB) repair by sensing DNA breaks and facilitating DNA repair through poly ADP-ribosylation of several DNA-binding and repair proteins. Inhibition of PARP1 results in collapsed DNA replication fork and double-strand breaks (DSBs). Accumulation of DSBs goes beyond the capacity of DNA repair response, ultimately resulting in cell death.

Atomically dispersed Fe-N-C catalyst displaying ultra-high stability and recyclability for efficient electroreduction of CO to CO.

To avoid the agglomeration of iron NPs and improve the dispersion of Fe SAs, we employed a mixed-ligand strategy to regulate the iron content in PCN-224(ZnFe) and PCN-222(ZnFe). Thanks to the sublimation of Zn and the Kirkendall effect, uniform dispersions of Fe SAs with 1.04-1.

Revealing the structure-activity relationship of two Cu-porphyrin-based metal-organic frameworks for the electrochemical CO-to-HCOOH transformation.

The eCO2RR activity is correlated to the internal structural character of the catalyst. We employed two types of structural models of porphyrin-based MOFs of PCN-222(Cu) and PCN-224(Cu) into heterogeneous catalysis to illustrate the effect of structural factors on the eCO2RR performance. The composite catalyst PCN-222(Cu)/C displays better activity and selectivity (η = 450 mV, FEHCOOH = 44.

Polyoxometalate-Based Compounds for Photo- and Electrocatalytic Applications.

Photo/electrocatalysis of water (H O) splitting and CO reduction reactions is a promising strategy to alleviate the energy crisis and excessive CO emissions. For the hydrogen evolution reaction (HER), oxygen evolution reaction (OER), and CO reduction reaction (CO RR) involved, the development of effective photo/electrocatalysts is critical to reduce the activation energy and accelerate the sluggish dynamics. Polyoxometalate (POM)-based compounds with tunable compositions and diverse structures are emerging as unique photo/electrocatalysts for these reactions as they offer unparalleled advantages such as outstanding solution and redox stability, quasi-semiconductor behaviour, etc.

Acquiring an effective CaO-based CO sorbent and achieving selective methanation of CO.

CO capture, utilization, and storage are promising strategies to solving the problems of superfluous CO or energy shortage. Here, mechanochemical reduction of CO by a MgH/CaH mixture was first performed, by which we achieve selective methanation of CO and acquire an effective CaO-based CO sorbent, simultaneously. The selectivity of methanation is near 100% and the yield of CH reaches 30%.

Self-Assembly of a Phosphate-Centered Polyoxo-Titanium Cluster: Discovery of the Heteroatom Keggin Family.

Over the past 200 years, the most famous and important heteroatom Keggin architecture in polyoxometalates has only been synthesized with Mo, W, V, or Nb. Now, the self-assembly of two phosphate (PO )-centered polyoxo-titanium clusters (PTCs) is presented, PTi and PTi , which display classic heteroatom Keggin and its trivacant structures, respectively. Because Ti has lower oxidate state and larger ionic radius than Mo , W , V , and Nb , additional Ti centres in these PTCs are used to stabilize the resultant heteroatom Keggin structures, as demonstrated by the cooresponding theoretical calculation results.

An adjustable dual-emission fluorescent metal-organic framework: Effective detection of multiple metal ions, nitro-based molecules and DMA.

A novel multifunctional Pb(II)-based MOF, [Pb(DBPT)]·(DMA)(HO) (1), with excellent chemical stability, was successfully assembled by connecting {PbO} unit with a multi-topic polycarboxylate ligand of 3-(3,5-dicarboxylphenyl)-5-(4-carboxylphenyl)-1-H-1,2,4-triazole (HDBPT). It exhibits dual fluorescence emissions at 380 nm (λ = 280 nm) and 540 nm (λ = 380 nm), respectively. Through the adjustable dual fluorescence emissions, it could act as a turn-off and turn-on switch for detecting N,N-dimethylacetamide (DMA) molecule.

The effect of KH on enhancing the dehydrogenation properties of the Li-N-H system and its catalytic mechanism.

Although recent works demonstrated that some potassium compounds that can be converted to KH during ball-milling or heat-treatment have obvious effects on enhancing the dehydrogenation properties of the Li-N-H system, the effect of KH on enhancing the dehydrogenation properties of the Li-N-H system and its catalytic mechanism remain unclear. In this study, the hydrogen desorption properties of the LiNH2-LiH system with alkali metal hydrides (LiH, NaH, or KH) were investigated and discussed. We find that the three types of hydrides are effective for enhancing the hydrogen desorption properties of the LiNH2-LiH system, among which, KH shows the best effect.

Construction of (3,6)-connected polyoxometalate-based metal-organic frameworks (POMOFs) from triangular carboxylate and dimerized Zn-ε-Keggin.

Using the methodology of extension of reduced transition metal-grafted ε-Keggin polyoxoanions with two types of terphenyl-based tricarboxylates of HL (3,5',3''-position substitution) and HL (4,5',4''-position substitution) we isolated two (3,6)-connected 3D polyoxometalate-based metal-organic frameworks, [TBA][HPMoO][ZnL] (1, YZU-105), and [TPA][HPMoO][ZnL]·0.5HO (2, YZU-106) (HL = [1,1';3',1''-terphenyl]-3,5',3''-tricarboxylic acid; HL = [1,1';3',1''-terphenyl]-4,5',4''-tricarboxylic acid; TBA = tetrabutylammonium; TPA = tetrapropylammonium). In both compounds, the building block was the dimerized form of Zn-{ε-HPMoO}.

A phase 2 study of methotrexate, etoposide, dexamethasone, and pegaspargase chemotherapy for newly diagnosed, relapsed, or refractory extranodal natural killer/T-cell lymphoma, nasal type: a multicenter trial in Northwest China.

The nasal type of extranodal natural killer/T-cell lymphoma is a rare aggressive lymphoma with poor prognosis. To discover a successful treatment, we investigated the efficacy and safety of chemotherapy with methotrexate, etoposide, dexamethasone, and polyethylene glycol-asparaginase (MESA). Three cycles of MESA were administered to 46 patients with new or relapsed/refractory natural killer/T-cell lymphoma.

Natural Killer/T Cell Lymphoma, Nasal Type: A Retrospective Clinical Analysis in North-Western China.

Background: Extranodal natural killer (NK)/T cell lymphoma (ENKTL) is an aggressive non-Hodgkin's lymphoma with high mortality and poor prognosis despite radiotherapy and chemotherapy. The current analysis aimed to assess the pathological features, clinical features, and prognostic indicators of ENKTL.

Material And Methods: 120 ENKTL patients were analyzed for pathologic diagnosis and clinical disease manifestations from April 2007 to October 2012.

[Influence of CD117 Expression on Response of Multiple Myeloma Patients to Chemotherapy].

Objective: To investigate the influence of CD117 expression on response of multiple myeloma patients to chemo-therapy.

Methods: A total of 65 cases of newly diagnosed multiple myeloma in our hospital from 2011 to 2013 were enrolled in this study. Cytogenetic abnormalities and immunophenotype were detected by using fluorescence in situ hybridization and flow cytometry before chemotherapy.

[Valproic Acid Represses Autophagy and Enhances the Anti-myeloma Activity of DNA-damaging Drugs].

Objective: To explore the effect of valproic acid(VPA) on anti-myeloma activity of Doxorubicin(DOX) or Melphalan(MEL) and its related mechanism.

Methods: Human multiple myeloma(MM) cells were treated with VPA of non-toxic dose in absence and presence of DOX or MEL at different concentrations (ie. IC10, IC20, IC40).

The first tritopic bridging ligand 1,3,5-tris(4-carboxyphenyl)-benzene (H3BTB) functionalized porous polyoxometalate-based metal-organic framework (POMOF): from design, synthesis to electrocatalytic properties.

Replacing the metal ions (or metal clusters) in routine MOFs with size-matched polyoxoanions to construct POM-based MOF materials (POMOF) combining well-defined crystalline structures, high surface area, regular and tunable cavities is the great challenge in the current POM chemistry area. In this work, we report a 2-fold interpenetrated porous POMOF, [TBA]6[H3PMo12O40]2[Zn8(BTB)2]·(∼35H2O), which exhibits effective catalytic activity towards bromate reduction, using the methodology of extension for the reduced transition-metal-grafted ε-Keggin polyoxoanions with an expanded tripodal bridging ligand of H3BTB. The simultaneous TGA/DSC-MS technique was applied in this work to identify the evolved gases and was proved to be an effective method for analysing the decomposition process.

Increased 14-3-3ζ expression in the multidrug-resistant leukemia cell line HL-60/VCR as compared to the parental line mediates cell growth and apoptosis in part through modification of gene expression.

Background: Acute myeloid leukemia (AML) recurrence is largely a result of multidrug resistance (MDR). We aimed to examine the role of 14-3-3ζ in AML chemosensitivity using HL-60 and vincristine-resistant HL-60/VCR cells.

Methods: The effects of 14-3-3ζ siRNA on the growth and cell cycle progression of HL-60 and HL-60/VCR cells were determined.

[Efficacy comparison between standard and reduced doses of bortezomib combined with adriamycin and dexamethasone in the treatment of patients with multiple myeloma].

Objective: To compare the efficacy and safety of standard or reduced doses of bortezomib combined with adriamycin and dexamethasone (PAD) in patients with multiple myeloma (MM).

Methods: Eighty-two newly diagnosed or refractory/relapsed patients received bortezomib [either 1.2-1.

Solvent effect on the construction of two microporous yttrium-organic frameworks with high thermostability via in situ ligand hydrolysis.

Two novel yttrium trimesates with open frameworks have been synthesized by the self-assembly of trimethyl 1,3,5-benzenetricarboxylate and Y(3+) ion in mixed solvent of dimethylformamide (DMF)/water and diethylformamide (DEF)/water, where changes of solvents with different molecular sizes lead to the formation of two similar three-dimensional frameworks with different spatial arrangement styles of the linkers around the Y(3+) centers, and solvent-dependent one-dimensional channels (ca. 6.2 x 7.

Investigation of flexible organic ligands in the molybdate system: delicate influence of a peripheral cluster environment on the isopolymolybdate frameworks.

By introducing the flexible 1,4-bis(1,2,4-triazol-1-ylmethyl)benzene (L(1)) and 1,4-bis(imidazole-1-ylmethyl)benzene (L(2)) ligands into the molybdate system under hydrothermal conditions, 12 novel isopolymolybdate frameworks were obtained: [CuL(1)(H(2)O)][Mo(3)O(10)] (1), [ML(1)(H(2)O)(2)][Mo(3)O(10)] [M = Cu (2), Zn (3), and Co (4)], [Cu(2)(L(1))(4)][theta-Mo(8)O(26)] (5), [Cu(4)(L(1))(4)][beta-Mo(8)O(26)](0.5)[gamma-Mo(8)O(26)](0.5).

[CMV pp65 gene modified dendritic cells activate autologous T cells].

Cytomegalovirus (CMV) infection is a dangerous complication in patients with chronic graft versus host disease (cGVHD). CMV-specific immunity depends on the activity of T cells. This study was aimed to investigate the effect of CMV pp65 gene modified dendritic cells (DCs) on activation of autologous T cells.