CaCO-Encapsulated polydopamine with an adsorbed TLR7 agonist for improved tumor photothermal immunotherapy.

Because of the tumor's recurrence and significant metastasis, the standard single-therapy paradigm has failed to meet clinical requirements. Recently, researchers have focused their emphasis on phototherapy and immunogenic cell death (ICD) techniques. In response to the current problems of immunotherapy, a multifunctional drug delivery nanosystem (PDA-IMQ@CaCO-blinatumomab, PICB) was constructed by using high physiological compatibility of polydopamine (PDA) and calcium carbonate (CaCO).

Panax notoginseng saponins promotes cutaneous wound healing and suppresses scar formation in mice.

Background & Aim: Panax notoginseng saponins are believed to promote wound healing due to its anti-proliferative effect on fibroblasts. The present work was therefore aimed to examine the beneficial effect of PNS on wound healing in vitro and in a murine model of cutaneous wound.

Methods: The in vitro effects of Panax notoginseng saponins on the proliferation of and nitric oxide (NO) synthesis in human fibroblast 3T3 cells were studied.

Protective effect and mechanism of Qiwei Tiexie capsule on 3T3-L1 adipocytes cells and rats with nonalcoholic fatty liver disease by regulating LXRα, PPARγ, and NF-κB-iNOS-NO signaling pathways.

Ethnopharmacological Relevance: Qiwei Tiexie capsule (QWTX) is a representative prescription of Tibetan medicine, which is widely used for long-term treatment of chronic liver disease and nonalcoholic fatty liver disease (NAFLD).

Aim Of The Study: This study explored the effects and mechanism of QWTX on 3T3-L1 adipocytes and NAFLD.

Materials And Methods: The 3T3-L1 preadipocytes and NAFLD rat model were used in the study.

[Water sources of dominant sand-binding plants in dry season in southern Horqin Sandy Land, China].

It's important to explore the water sources of sand-binding plants and their relationship to reveal the mechanism underling species coexistence and vegetation stability. In the present study, 12 sand-binding species in two typical habitats (fixed dune and dune slack) in southern Horqin Sandy Land were selected. The δD and δO values of plant water, rain water, ground water and soil water were determined, and the percentages of soil water at different depths used by plants were calculated with the IsoSource model.

The poor prognosis of the primary gastric epithelioid angiosarcoma: A case report.

Rationale: Primary gastric epithelioid angiosarcoma is a highly aggressive endothelial cell malignancy and may pose a great diagnostic challenge.

Patient Concerns: Here we describe the case of a 56-year-old man presented with melena and epigastric dull pain for 2 weeks.

Diagnosis: Primary gastric epithelioid angiosarcomas: the definitive diagnosis was provided by immunohistochemical analysis with endothelial markers such as cluster of differentiation 31 (CD31), ether-a-go-go-related gene (ERG), and Freund leukemia integration (FLI-1).

[Effect of ASO Blood Stasis Syndrome Serum on Vascular Endothelial Cell Injury and Regulation of Taohong Siwu Decoction on it].

Objective: To explore the effect of arteriosclerosis obliterans (ASO) blood stasis syndrome (BSS) serum on vascular endothelial cell injury and to study the regulation of Taohong Siwu Decoction (TSD) on it.

Methods: Umbilical vein endothelial cell culture system was established. The serum endothelial cell injury model with ASO BSS was prepared.

Effects of crowding and sex on fecal cortisol levels of captive forest musk deer.

Background: Restricted space and close contact with conspecifics in captivity may be stressful for musk deer, as they are highly territorial and solitary in the wild. So we tested the effects of crowding on stress of forest musk deer (Moschus berezovskii) in heterosexual groups, using fecal cortisol analysis as a non-invasive method. 32 healthy adults during non-breeding seasons were chose as our experimental objects.

[The phenotypic characteristics of human fetal liver progenitors and clonal culture in vitro].

Objective: To investigate the phenotypic characteristics of human fetal liver cells (FLCs) and to obtain the homogenous hepatic progenitors with cloning.

Methods: Immunofluorescence and flow cytometry were used to determine the phenotypes of the FLCs. The proliferating colonies were isolated using clone ring in different culture conditions.