Correlation of distribution characteristics and dynamic changes of gut microbiota with the efficacy of immunotherapy in EGFR-mutated non-small cell lung cancer.

Background: The effects of gut microbiota and metabolites on the responses to immune checkpoint inhibitors (ICIs) in advanced epidermal growth factor receptor (EGFR) wild-type non-small cell lung cancer (NSCLC) have been studied. However, their effects on EGFR-mutated (EGFR +) NSCLC remain unknown.

Methods: We prospectively recorded the clinicopathological characteristics of patients with advanced EGFR + NSCLC and assessed potential associations between the use of antibiotics or probiotics and immunotherapy efficacy.

A Mechanism Study of Redox Reactions of the Ruthenium-oxo-polypyridyl Complex.

Over the years, Ru(bpy)(py)(O)([RuO]) has garnered considerable interest owing to its extensive use as a polypyridine mono-oxygen complex. However, as the active-site Ru=O bond changes during the oxidation process, [RuO] can be used to simulate the reactions of various high-priced metallic oxides. In order to elucidate the hydrogen element transfer process between the Ruthenium-oxo-polypyridyl complex and organic hydride donor, the current study reports on the synthesis of [RuO], a polypyridine mono-oxygen complex, in addition to and (organic hydride compounds) and derivative: .

Thermodynamics Evaluation of Selective Hydride Reduction for α,β-Unsaturated Carbonyl Compounds.

The selective reduction of α,β-unsaturated carbonyl compounds is one of the core reactions and also a difficult task for organic synthesis. We have been attempting to study the thermodynamic data of these compounds to create a theoretical basis for organic synthesis and computational chemistry. By electrochemical measurement method and titration calorimetry, in acetonitrile at 298 K, the hydride affinity of two types of unsaturated bonds in α,β-unsaturated carbonyl compounds, their single-electron reduction potential, and the single-electron reduction potential of the corresponding radical intermediate are determined.

New Insight into the Mechanism of NADH Model Oxidation by Metal Ions in Nonalkaline Media.

For a long time, it has been controversial that the three-step (e-H-e) or two-step (e-H) mechanism was used for the oxidation of nicotinamide adenine dinucleotide coenzyme (NADH) and its models by metal ions in nonalkaline media. The latter mechanism has been accepted by the majority of researchers. In this work, 1-benzyl-1,4-dihydronicotinamide (BNAH) and 1-phenyl-l,4-dihydronicotinamide are used as NADH models and ferrocenium (Fc) metal ion as an electron acceptor.

[Blood Transfusion Selection in Patients with Autoimmune Hemolytic Anemia Producing Class Antibodies].

Objective: To analyze the reasons for the incompatibility of cross matching in lymphoma patients complicated by autoimmune hemolytic anemia (AIHA), and to provide compatible blood to patients for multiple blood transfusion.

Methods: The test tube method was used for routine identification of ABO blood group, Rh typing and direct anti-globulin test; the patients antibody was identified by saline water method, micro column gel card; and the saline water method, Polybrene method and antiglobulin method were used for blood cross matching test of the patients.

Results: In the serum of the patient, positive autoantibodies were detected, in the elution, the Ce antibody was detected.

Controlling liquid crystal pretilt angle with photocurable prepolymer and vertically aligned substrate.

We demonstrate a new approach to control the pretilt angle of liquid crystals (LCs) with photocurable prepolymer in a cell fabricated with vertically aligned substrates. During UV exposure, prepolymer approaches and is polymerized on the substrate surfaces because of the vertical phase separation induced by differences in the surface tensions of the employed materials. After polymerization, the polymer structure formed on the substrate alters its surface polarity and changes the pretilt angle of the LC cell.

Design, synthesis, and biological evaluation of crenatoside analogues as novel influenza neuraminidase inhibitors.

Natural products, especially derived from TCMH, have been found to exert antiviral effects against influenza virus. Crenatoside, a phenylethanoid glycoside from Pogostemon cablin Benth, which has been shown as a novel effective NA inhibitor previously, is considered as the leading compound for our further SARs studies. This work presented design, synthesis of novel crenatoside analogues from readily available d-Glucose and l-rhamnose in a convergent manner.

Polarization-insensitive liquid crystal microlens array with dual focal modes.

We demonstrate a liquid crystal (LC) microlens array (MLA) fabricated by LCs possessing negative dielectric anisotropy, in conjunction with a cell with a three-electrode structure. The presented LC MLA is polarization-insensitive and can be operated in both concave and convex modes. The shortest focal length of the LC MLA is -2.

[Effect of five species of Epimedium on growth of cartilage and proliferation of cartilage cell in vitro].

Objective: To observe the effect of Epimedium brevicornum, E. sagittatum, E. koreanum, E, wushanense and E.