Population pharmacokinetic characteristics of sirolimus in healthy Chinese subjects and renal transplant patients.

Aim: To identify the factors affecting the pharmacokinetics (PKs) of sirolimus in healthy Chinese subjects and renal transplant patients.

Methods: A population PK model of sirolimus was constructed using dense data from 22 healthy volunteers and sparse data from 105 renal transplant patients.

Results: The data were well described by a two-compartment model with first-order absorption.

Tomitella cavernea sp. nov., an actinomycete isolated from soil.

A Gram-staining-positive, aerobic, non-spore-forming, irregular rod-shaped actinobacterium, designated YIM C00895(T), was isolated from a soil sample collected from Jiuxiang Scenic Region, Yunnan province, south-west China. The strain was able to grow at 10-28 °C, pH 6.0-10.