Cognitive impairment after traumatic brain injury is associated with reduced long-term depression of excitatory postsynaptic potential in the rat hippocampal dentate gyrus.

Traumatic brain injury can cause loss of neuronal tissue, remote symptomatic epilepsy, and cognitive deficits. However, the mechanisms underlying the effects of traumatic brain injury are not yet clear. Hippocampal excitability is strongly correlated with cognitive dysfunction and remote symptomatic epilepsy.

Kinematic characteristics of lumbar spinous processes during axial rotation in patients with lumbar degenerative disc disease lateral lumbar interbody fusion and intervention.

Background: Data about minimally invasive surgery for the treatment of patients with degenerative disc disease (DDD) has been reported. However, no quantitative knowledge about the biomechanical characteristics of the spinous processes in patients with DDD after operation was reported in the literature.

Methods: Fourteen adult patients with DDD at the L3-4 level were recruited and scanned using computed tomography (CT) to construct three-dimensional (3D) anatomical vertebral models of L2-5.

Utilisation of adsorption and desorption for simultaneously improving protein crystallisation success rate and crystal quality.

High-quality protein crystals of suitable size are an important prerequisite for applying X-ray crystallography to determine the 3-dimensional structure of proteins. However, it is often difficult to obtain protein crystals of appropriate size and quality because nucleation and growth processes can be unsuccessful. Here, we show that by adsorbing proteins onto porous polystyrene-divinylbenzene microspheres (SDB) floating on the surface of the crystallisation solution, a localised high supersaturation region at the surface of the microspheres and a low supersaturation region below the microspheres can coexist in a single solution.

Effects of glucocorticoids on traumatic brain injury related critical illness-related corticosteroid insufficiency.

Background: Traumatic brain injury (TBI) is a heterogeneous condition that can lead to critical LLLness-related corticosteroid insufficiency (CIRCI) causing a high mortality and morbidity. Glucocorticoids were widely used in the clinical management of TBI, but their benefit has been challenged in some studies and their efficacy, especially for treating CIRCI in TBI patients, remains unclear.

Methods: We conducted a meta-analysis of published data to determine if the controversy is related to clinical dosing and timing of glucocorticoids (GCs) application.

[Computational-fluid-dynamical analysis of the flow field of forearm flap with four types of venous anastomotic techniques].

Purpose: Using the computational fluid dynamics to analyse the alteration of flow field of free forearm flap with 4 different venous anastomotic techniques, and to preliminarily explore its clinical significance.

Methods: Three dimensional geometric models of radial forearm flap with 4 types of anastomotic techniques between radial vein and recipient vessels were established by Pro/E (Wildfire 4.0) as follow: type I(matched anastomosis), type II(stump anastomosis), type III (angular anastomosis) and type IV(end-to-side anastomosis).

[Chronic effects of oligomeric Aβ(1-42) on hippocampal synaptic plasticity in vivo].

Synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD), is widely considered as one of the major mechanisms underlying learning and memory. This study explored hippocampal synaptic plasticity and spatial memory formation of an Alzheimer's disease (AD) rat model established by intrahippocampal injection of oligomeric Aβ(1-42). Twenty four Sprague-Dawley rats at 2.

[Establishment of hemodynamic model of human radial forearm free flap].

Purpose: To preliminarily establish a hemodynamic 3D numeric model of radial forearm free flap with vascular pedicle of radial artery and vein, and discuss its scientific workability.

Methods: The 3D geometric model of 50mm×80mm×10mm radial forearm flap was established by Pro/E(Wildfire 4.0).

Traumatic brain injury impairs synaptic plasticity in hippocampus in rats.

Background: Traumatic brain injury (TBI) often causes cognitive deficits and remote symptomatic epilepsy. Hippocampal regional excitability is associated with the cognitive function. However, little is known about injury-induced neuronal loss and subsequent alterations of hippocampal regional excitability.

[Effect of low-intensity pulsed ultrasound on the enchondral bone formation in posterolateral lumbar fusion in rabbits].

Objective: To observe the effect of daily low-intensity pulsed ultrasound (LIPUs) therapy on improving the enchondral bone formation in lumbar fusion in rabbit models, and to explore its possible mechanism.

Methods: Posterolateral noninstrumented bilateral fusions were performed at the L5 approximately L6 levels in 20 New Zealand rabbits. The autograft iliac bone was implanted on the left side, and the hydroxyapatite bioceramic artificial bone on the right.