Publications by authors named "Bao-Li Ma"
Article Synopsis
- Experimental autoimmune encephalomyelitis (EAE) is a model for studying multiple sclerosis, mainly using Lewis rats and various murine models, but this study introduces a new model using Wistar rats and guinea pig spinal cord antigens.
- The study found that autoreactive T cells could be completely inhibited in vitro using CTLA4Ig, which blocks T cell costimulation, but this inhibition could be reversed with the addition of IL-2.
- Additionally, CTLA4Ig treatment reduced the expression of IL-2 receptors and T cell activity while not affecting IL-10 synthesis, supporting the idea that B7-blocking therapies could be a potential treatment for multiple sclerosis.
