New Bisabosquals from sp. PH30583 Elicited on Solid Media.

sp. PH30583 cultured in liquid medium only led to one structure type of novel isochroman dimers. Using the one strain-many compounds strategy, the reinvestigation of the metabolites from sp.

Benzopyran derivatives from endophytic JC-15 in and their bioactivities.

Five new benzopyran derivatives (-) and a new natural product () were isolated from endophytic in and determined as (R)-2,3-dihydro-2,5-dihydroxy-2-methylchromen-4-one (), (2R, 4S)-2,3-dihydro-2-methyl-benzopyran-4,5-diol (), (R)-3-methoxyl-1-(2,6-dihydroxy phenyl)-butan-1-one (), 7-O-α-d-ribosyl-5-hydroxy-2-methyl-4H-chromen-4-one (), 7-O-α-d-ribosyl-2,3-dihydro-5-hydroxy-2-methyl-chromen-4-one (), daldinium A (). These compounds were evaluated for their antimicrobial activity, anti-acetylcholinesterase, nitric oxide inhibition, anticoagulant, photodynamic antimicrobial activities and glucose uptake of adipocytes. Some compounds showed photoactive antimicrobial activities and glucose uptake stimulating activities.

New bioactive compounds from aquatic endophyte Chaetomium globosum.

Two new oxidation products-related aureonitol and cytochalasan were isolated from Chaetomium globosum fermented in Chinese yam (Dioscorea opposita) and determined as 10,11-dihydroxyl- aureonitol (1) and yamchaetoglobosin A (2). Compound 2 indicated significant inhibitory effect on nitric oxide production in LPS-activated macrophages, anti-acetylcholinesterase activity with the inhibition ratios of 92.5, 38.

Phytotoxic, antibacterial, and antioxidant activities of mycotoxins and other metabolites from Trichoderma sp.

A new natural mycotoxin was isolated from the fermentation broth of Trichoderma sp. Jing-8 and the structure was determined as alternariol 1'-hydroxy-9-methyl ether (1), together with twelve known compounds. The structures were elucidated on the basis of their 1D, 2D NMR spectra and mass spectrometric data.

Metabolites from Penicillium sp. Associated with Paris polyphylla.

One new gentisyl alcohol derivative and-seven known compounds were isolated from the culture of Penicillium sp. Their chemical structures were.elucidated by extensive spectroscopic analysis.