The Long Terminal Repeats of ERV6 Are Activated in Pre-Implantation Embryos of Cynomolgus Monkey.

Precise gene regulation is critical during embryo development. Long terminal repeat elements (LTRs) of endogenous retroviruses (ERVs) are dynamically expressed in blastocysts of mammalian embryos. However, the expression pattern of LTRs in monkey blastocyst is still unknown.

[Differential proteins in esophageal squamous cell line EC9706/CDDP identified by SILAC quantitative proteomic approach].

Multidrug resistance (MDR) is one of the main causes leading to the failure in cancer treatment. Differential proteins between esophageal squamous cell carcinoma (ESCC) cell line EC9706 and its cisdiamminedichloroplatinum (CDDP)-resistant subline EC9706/CDDP revealed by quantitative analysis may provide deeper insights into the molecular mechanisms of MDR implicated in ESCC. EC9706/CDDP was generated by exposure of its parental sensitive EC9706 to a step-wise increase of CDDP concentration during EC9706 cultivation.

The establishment and characterization of adriamycin-resistant cell lines derived from Saos-2.

Background: The aim was to establish and characterize adriamycin (ADM)-resistant cell lines.

Material/methods: Two cell lines, named Saos-2/ADM1 and Saos-2/ADM4, resistant to ADM, were established after 167 days.

Results: The resistance indices of methotrexate for the Saos-2/ADM1 and Saos-2/ADM4 cell lines to ADM were 49.

Bis{tris-[3-(2-pyrid-yl)pyrazole]manganese(II)} dodeca-molybdosilicate hexa-hydrate.

The title compound, [Mn(C(8)H(7)N(3))(3)](2)[SiMo(12)O(40)]·6H(2)O, consists of an [SiMo(12)O(40)](4-) heteropolyanion, lying on a centre of inversion, and a complex [Mn(C(8)H(7)N(3))(3)](4+) cation. The Mn(II) atom of the cation is hexa-coordinated in a distorted octa-hedral geometry by six N atoms from three chelating 3-(2-pyrid-yl)pyrazole ligands. In the heteropolyanion, the four O atoms of the tetra-hedral SiO(4) group each half-occupy eight sites due to Si lying on the centre of inversion.