Publications by authors named "Bao-Bao Yu"
Ecteinascidin 743 is a famous marine drug used in anticancer treatments. In this work, a series of simplified hybrids/analogues have been synthesized by employing a newly developed chemistry that integrates the partial structural features of two anticancer bis-tetrahydroisoquinoline alkaloids ecteinascidin 743 and cribrostatin 4. The described Suzuki-coupling protocol enabled us to easily introduce variable functionalities at the C3 position of the basic skeleton of bis-tetrahydroisoquinoline alkaloids for the first time.
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- Triple-negative breast cancer (TNBC) is a challenging health issue for women, with no effective treatments currently available.
- The study focuses on AA005, a compound that shows strong cytotoxic properties against TNBC cells, effectively inhibiting their growth at low concentrations.
- AA005 disrupts the cell's energy production by affecting mitochondrial function and glucose uptake, leading to irreversible damage and cell death, while also proving effective in animal models for potential future use in TNBC therapy.
Article Synopsis
- - Plumisclerin A is a complex natural compound from marine sources, known for its unique structure and potential cancer-fighting properties.
- - The research involved creating new analogues of plumisclerin A by altering its tricyclo[4.3.1.0]decane core, starting from a common intermediate, to see if the modifications could maintain bioactivity against cancer cells.
- - Several new analogues were found to have similar effectiveness as the original compound in inhibiting cancer cell growth, and the study suggests that the position of added lipophilic chains on the core structure can vary, opening up paths for producing more effective compounds.