High-Throughput Prediction of Metal-Embedded Complex Properties with a New GNN-Based Metal Attention Framework.

Metal-embedded complexes (MECs), including transition metal complexes (TMCs) and metal-organic frameworks (MOFs), are important in catalysis, materials science, and molecular devices due to their unique metal atom centrality and complex coordination environments. However, modeling and predicting their properties accurately is challenging. A new metal attention (MA) framework for graph neural networks (GNNs) was proposed to address the limitations of traditional methods, which fail to differentiate core coordination structures from ordinary covalent bonds.

PAR2 promotes malignancy in lung adenocarcinoma.

Proteinase-activated receptor-2 (PAR2) is closely linked to tumor malignancy, but its biological role in cancer remains underexplored. In this study, we assessed PAR2 expression in lung adenocarcinoma (LUAD) and normal lung tissues, analyzed associations between clinicopathological features and survival rates, and confirmed that PAR2 promotes apoptosis resistance and reduces cisplatin-induced cytotoxicity in lung cancer cells. Using TCGA datasets, western blotting, qPCR, and immunohistochemistry (IHC), we observed a significant increase in PAR2 levels in LUAD samples compared to normal tissues (P<0.

Effects of two strains isolated from different sources on the growth of .

Microbial inoculants offer an environmentally friendly approach to enhance plant growth and control disease. In this study, two strains, HKSSLJEBR3 (R3) and Ya-1 were isolated from pepper plant roots and tropical rainforest soil, respectively. Both strains exhibited strong antifungal activity against f.

Research into the Influence of Filtration Media Microstructure on Oil-Water Separation Performance.

Oil-water separation materials with specialized wettability have garnered significant attention in the field of oil-water separation due to the advantages of simple use and no secondary pollution. However, the adsorptive contamination of the filter surface by impurity phases and surfactants can cause a shift in the wettability of the filter surface. For efficient oil-water separation and improved resistance to adherent contamination on the oil-water separation membrane surface, herein, superwetted Cu nanofilms and smooth hydrophobic surfaces were prepared on SSM substrates by one-step electrodeposition and immersion methods, respectively.

Influence of Surface Wettability of Nonhomogeneous Proppant on Hydraulic Fracture Inflow Performance.

Quartz sand proppant is widely used in hydraulic fracturing and the extraction of low-permeability reservoirs to prevent fracture closure and enhance reservoir recovery effectively. The influence of proppant size and type on well productivity has been widely studied, but the mechanism of proppant surface wettability on the hydraulic fracture inflow performance has not been thoroughly investigated. To further understand the influence of proppant wettability on fracture inflow performance, in this work, a hydrophobic quartz sand proppant was prepared by a simple dip-coating method using silane solution with a static water contact angle of 136.

[Analysis of Carbon Emission Reduction Potential and Discussion on the Green Development Path in Gansu-Qinghai Regions].

The energy resources are rich, and the ecological environment is fragile in Gansu-Qinghai regions, which are facing problems in the coordinated development of green as well as low carbon transformation and high-quality economy. Based on the reality of Gansu-Qinghai regions, this study deeply analyzed the characteristics of regional carbon emissions； constructed the system dynamics model between carbon emissions and population, economy, energy, and policy； clarified the relationship between them； and probed into the future green development path. The results showed that： ① In recent years, the total and per capita carbon emissions in Gansu-Qinghai regions have been on the rise.

Enhancing Lesion Detection in Inflammatory Myelopathies: A Deep Learning-Reconstructed Double Inversion Recovery MRI Approach.

Background And Purpose: The imaging of inflammatory myelopathies has advanced significantly over time, with MRI techniques playing a pivotal role in enhancing lesion detection. However, the impact of deep learning (DL)-based reconstruction on 3D double inversion recovery (DIR) imaging for inflammatory myelopathies remains unassessed. This study aims to compare acquisition time, image quality, diagnostic confidence, and lesion detection rates among sagittal T2WI, standard DIR, and DL -reconstructed DIR in patients with inflammatory myelopathies.

PGC-1α regulation by FBXW7 through a novel mechanism linking chaperone-mediated autophagy and the ubiquitin-proteasome system.

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a key regulator of mitochondrial biogenesis and antioxidative defenses, and it may play a critical role in Parkinson's disease (PD). F-box/WD repeat domain-containing protein (FBXW7), an E3 protein ligase, promotes the degradation of substrate proteins through the ubiquitin-proteasome system (UPS) and leads to the clearance of PGC-1α. Here, we elucidate a novel post-translational mechanism for regulating PGC-1α levels in neurons.

Comparative Efficacy of Deep Brain Stimulation to the Globus Pallidus Internus Versus the Subthalamic Nucleus in Parkinson's Disease.

Background: In recent years, the incidence of Parkinson's disease has gradually increased, and the application of dopamine drugs has been limited, so there is an urgent need to explore a more effective treatment method to treat Parkinson's disease effectively treated. Subthalamic nucleus-deep brain stimulation and globus pallidus internus-deep brain Subthalamic nucleus-deep brain stimulation and globus pallidus internus-deep brain stimulation are the two treatments for Parkinson's disease. However, there is no clear conclusion as to which of these two methods is more effective.

, a New Host of Causing Anthracnose in China.

Heliconia subulata is a common ornamental plant, it has been widely planted in southern China for greening parks, roads, and residential areas. H. subulata plants with spots on their leaves were observed in East Coast Wetland Park (18°16'53.

CDGT: Constructing diverse graph transformers for emotion recognition from facial videos.

Recognizing expressions from dynamic facial videos can find more natural affect states of humans, and it becomes a more challenging task in real-world scenes due to pose variations of face, partial occlusions and subtle dynamic changes of emotion sequences. Existing transformer-based methods often focus on self-attention to model the global relations among spatial features or temporal features, which cannot well focus on important expression-related locality structures from both spatial and temporal features for the in-the-wild expression videos. To this end, we incorporate diverse graph structures into transformers and propose a CDGT method to construct diverse graph transformers for efficient emotion recognition from in-the-wild videos.

Empowering Low-Temperature Lithium-Sulfur Batteries: Unlocking the Potential of Transition Metal Alloy-Based Cathode Materials.

At low temperatures, lithium-sulfur (Li-S) batteries have poor kinetics, resulting in extreme polarization and decreased capacity. In this study, we investigated the electrochemical performance of Li-S batteries utilizing transition metal alloy-based cathode materials. Specifically, binary transition metal alloys (FeNi, FeCo, and NiCo) are integrated into a porous carbon nanofiber (CNF) matrix as composite cathode material.

Feasibility and efficacy of endoscopy with blue laser imaging for the detection and diagnosis of cardia polyps: A single-center randomized controlled study.

Objective: To compare the detection rate and diagnostic accuracy of cardia polyps using endoscopy with blue laser imaging (BLI) and white-light imaging (WLI).

Methods: Patients were randomly divided into the BLI group and WLI group according to the endoscopic procedures. BLI followed by WLI was conducted in the BLI group, whereas WLI followed by BLI examination was conducted in the WLI group.

Graves' disease and the risk of five autoimmune diseases: A Mendelian randomization and colocalization study.

Background: Epidemiological studies have consistently demonstrated a high prevalence of concurrent autoimmune diseases in individuals with Graves' disease (GD).

Objective: The objective of this study is to establish a causal association between GD and autoimmune diseases.

Methods: We employed a two-sample Mendelian randomization (MR) to infer a causal association between GD and five autoimmune diseases, namely rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Crohn's disease (CD), ulcerative colitis (UC), and amyotrophic lateral sclerosis (ALS), in the East Asian and European population.

High lymphocyte signature genes expression in parathyroid endocrine cells and its downregulation linked to tumorigenesis.

Background: To date, because of the difficulty in obtaining normal parathyroid gland samples in human or in animal models, our understanding of this last-discovered organ remains limited.

Methods: In the present study, we performed a single-cell transcriptome analysis of six normal parathyroid and eight parathyroid adenoma samples using 10 × Genomics platform.

Findings: We have provided a detailed expression atlas of parathyroid endocrine cells.

Multifunctional Heterostructured FeO-FeTe@MCM Electrocatalyst Enabling High-Performance Practical Lithium-Sulfur Batteries Via Built-in Electric Field.

The development of capable of simultaneously modulating the sluggish electrochemical kinetics, shuttle effect, and lithium dendrite growth is a promising strategy for the commercialization of lithium-sulfur batteries. Consequently, an elaborate preparation method is employed to create a host material consisting of multi-channel carbon microspheres (MCM) containing highly dispersed heterostructure FeO-FeTe nanoparticles. The FeO-FeTe@MCM exhibits a spontaneous built-in electric field (BIEF) and possesses both lithophilic and sulfophilic sites, rendering it an appropriate host material for both positive and negative electrodes.

Distribution of rhizosphere fungi of on the Qinghai-Tibet Plateau.

is a major species in the alpine meadow communities of the Qinghai-Tibet Plateau (QTP); it plays a crucial role in maintaining the ecological balance of these meadows. Nevertheless, little is known about the rhizosphere fungi associated with on the Qinghai Tibet Plateau. In this study, we used Illumina Miseq to investigate the fungal diversity, community structure, and ecological types in the root and rhizosphere soil of across eight areas on the QTP and analyzed the correlation between rhizosphere fungi of and environmental factors.

Digital medicine and minimally invasive surgery in pediatric hepatoblastoma: An update.

Hepatoblastoma (HB) is the most common liver malignancy in children, accounting for approximately 60 % of liver tumors in this population. However, the exact cause of HB remains unclear. The combination of surgery and neoadjuvant chemotherapy has significantly improved the overall survival rate of children with HB, increasing it from 40 % in the past to over 70 %.