Insulin-activated store-operated Ca entry via Orai1 induces podocyte actin remodeling and causes proteinuria.

Podocyte, the gatekeeper of the glomerular filtration barrier, is a primary target for growth factor and Ca signaling whose perturbation leads to proteinuria. However, the effects of insulin action on store-operated Ca entry (SOCE) in podocytes remain unknown. Here, we demonstrated that insulin stimulates SOCE by VAMP2-dependent Orai1 trafficking to the plasma membrane.