Transcriptome-Based Network Analysis Related to Histone Deacetylase Genes and Identified EMP1 as a Potential Biomarker for Prognosis in Bladder Cancer.

Background: Abnormal expression and function of histone deacetylases (HDACs) are closely associated with the development of bladder cancer (BCa). Systematic elucidation of the role of HDACs in BCa is expected to improve BCa prognosis and treatment strategies.

Methods: We explored the correlation and expression patterns of HDAC family genes in BCa.

Overtaking maneuvers on two-lane highways under the microscope: Exploration of a multidimensional framework for the analysis of safety, comfort and efficiency using simulator data.

An unreasonable overtaking attempt on two-lane highways could cause drivers to suffer in terms of driving safety, comfort, and efficiency. Several external factors related to the traffic environment (e.g.

Brown Adipose Tissue Promotes Autologous Fat Grafts Retention Possibly Through Inhibiting Wnt/β-Catenin Pathway.

Background: In plastic surgery, autologous fat grafts (AFG) play an important role because of their abundant supply, biocompatibility, and low rejection rate. However, the lower retention rate of fat grafts limits their widespread use. Brown adipose tissue (BAT) can promote angiogenesis and regulate the level of associated inflammation.

Exosomes Derived from Adipose Stem Cells Enhance Angiogenesis in Diabetic Wound Via miR-146a-5p/JAZF1 Axis.

Chronic trauma in diabetes is a leading cause of disability and mortality. Exosomes show promise in tissue regeneration. This study investigates the role of exosomes derived from adipose stem cells (ADSC-Exos) in angiogenesis.

Study on the Application of Concentrated Growth Factor Combined With Adipose Transplantation in Repairing Depressed Deformities of Soft Tissue in the Face.

Background: Autologous fat is a rich source of adipose tissue that is safe for transplantation. Decreasing the long-term absorption rate is key to improve the survival of transplanted adipose tissue. The aim of this study was to assess the effect of concentrated growth factor (CGF) on the survival of transplanted adipose tissue for repair of facial depression malformations.

Driving Behavior Based Relative Risk Evaluation Using a Nonparametric Optimization Method.

Evaluating risks when driving is a valuable method by which to make people better understand their driving behavior, and also provides the basis for improving driving performance. In many existing risk evaluation studies, however, most of the time only the occurrence frequency of risky driving events is considered in the time dimension and fixed weights allocation is adopted when constructing a risk evaluation model. In this study, we develop a driving behavior-based relative risk evaluation model using a nonparametric optimization method, in which both the frequency and the severity level of different risky driving behaviors are taken into account, and the concept of relative risk instead of absolute risk is proposed.

Clinical experience of the use of Integra in combination with negative pressure wound therapy: an alternative method for the management of wounds with exposed bone or tendon.

The use of Integra has attracted great interest in the treatment of wounds with exposed bone or tendon, which may lead to associated morbidities. However, the use of Integra alone results in poor wound outcomes. We conducted a randomized clinical study to evaluate the combined effects of Integra and negative pressure wound therapy (NPWT).

A case report of pyopneumopericardium following bungee jumping in a patient with tuberculosis.

Rationale: Pyopneumopericardium related to bungee jumping is a rare occurrence in the current antibiotic era. We present a case of esophagus-seeded Streptococcus sanguinis pyopneumopericardium in a young man with tuberculosis who had just completed bungee jumping.

Patient Concern: A 27-year-old man was hospitalized with a 1-day history of fever, chest tightness, and intermittent sharp chest pain after bungee jumping for the first time.

Towards better road safety management: Lessons learned from inter-national benchmarking.

Inter-national benchmarking of road safety, with the purpose of achieving continuous improvement by learning lessons from existing best practices, has currently been widely encouraged by most countries as an emerging management tool to improve the level of road safety. However, performing a successful road safety benchmarking practice is by no means easy. Challenges exist from ascertaining the benchmarking framework at the very beginning to making final policy decisions.

Platelet-rich fibrin as an alternative adjunct to tendon-exposed wound healing: A randomized controlled clinical trial.

Background: The use of platelet-rich fibrin (PRF) has attracted great interest in the treatment of oral and maxillofacial procedures, gingival recessions, and bone healing. However, PRF has been reported hardly to prepare wound bed before skin grafting. This randomized clinical study sought to identify the effect of PRF as an alternative adjunct to tendon-exposed wound healing.

Serious injuries: an additional indicator to fatalities for road safety benchmarking.

Objectives: Almost all of the current road safety benchmarking studies focus entirely on fatalities, which, however, represent only one measure of the magnitude of the road safety problem. The main objective of this article was to investigate the possibility of including the number of serious injuries in addition to the number of fatalities for road safety benchmarking and to further illuminate its impact on the countries' rankings.

Methods: We introduced the technique of data envelopment analysis (DEA) to the road safety domain and developed a DEA-based road safety model (DEA-RS) in this study.

Road safety development in Europe: a decade of changes (2001-2010).

To evaluate the road safety development of a country over time, the percentage change in the number of road fatalities is traditionally the main indicator. However, simply considering the reduction in the road fatalities may not correctly reflect the real improvement in road safety because the transport circumstances of a country underlying the road fatalities also change every year. In this study, we present a new way for measuring the road safety performance change over time, which is to use the technique of data envelopment analysis (DEA) and the Malmquist productivity index.

[Epidemiological study on traffic accident in Shanghai from 2000 to 2002].

Objective: Data on traffic accident from year 2000 to 2002 were collected and testified. Epidemiological study was carried out to find the main risk factors of traffic accident.

Methods: The spatial distribution was conducted by means of Geographic Information System (GIS) and were marked on Shanghai digitalized map with different layers by different colors.