A dual-mode colorimetric/photothermal lateral flow biosensor based on Au/TiCT for HIV-DNA detection.

Background: Traditional lateral flow biosensors (LFBs), which utilize colorimetric signals as output, possess the virtues of simplicity and rapidity. However, it also suffers from insufficient sensitivity and limited reliability. It is well known that the results of LFBs can be false positive, and it is difficult to perform accurate quantification under low-abundance targets.

Using primary and routinely collected data to determine prevalence and patterns of multimorbidity in rural China: a representative cross-sectional study of 6474 Chinese adults.

Background: In China, rising chronic diseases has coincided with the increasing burden of multimorbidity, particularly for vulnerable populations. Limited primary data are available to understand the prevalence and patterns of multimorbidity, especially in resource-limited rural areas. This study aims to conduct robust evaluations of the prevalence and patterns of multimorbidity among rural adults in China, and to compare the differences in prevalence and patterns when using primary data alone versus in combination with routinely collected data.

Application of Submandibular Intubation as Alternative to Elective Short-Term Tracheotomy for Particular Cases of Oral and Maxillofacial Tumors Resection and Defects Reconstruction.

Objective: To describe the cases of oral and maxillofacial tumors (OMFT) resection and defects reconstruction under submandibular intubation (SMI) performed in our institution; secondly, to systematically review and analyze the characteristics of studies about SMI in oral and maxillofacial surgery to estimate the incidence rate of complication.

Method: Data related to all 6 patients included in this study were prospectively collected from November 2016 to November 2023. The tract for endotracheal tube was created by bluntly dissection from the submandibular area to the floor of mouth.

Long-term survival outcomes of laparoscopic surgery in patients with colorectal cancer: A propensity score matching retrospective cohort study.

Objective: Colorectal cancer (CRC) surgeries can be performed using either laparoscopic or open laparotomy approaches. However, the long-term outcomes based on tumor location and age remain unclear. This study compared the long-term outcomes of laparoscopic and laparotomy surgeries in patients with CRC, focusing on tumor location and age to identify suitable subgroups and determine an optimal cut-off age.

Designer topological-single-atom catalysts with site-specific selectivity.

Designing catalysts with well-defined, identical sites that achieve site-specific selectivity, and activity remains a significant challenge. In this work, we introduce a design principle of topological-single-atom catalysts (T-SACs) guided by density functional theory (DFT) and Ab initio molecular dynamics (AIMD) calculations, where metal single atoms are arranged in asymmetric configurations that electronic shield topologically misorients d orbitals, minimizing unwanted interactions between reactants and the support surface. Mn/CeO catalysts, synthesized via a charge-transfer-driven approach, demonstrate superior catalytic activity and selectivity for NO removal.

Study the effect of ATCC 14917 for caries prevention and anti-obesity.

Introduction: A complicated scenario where "multiple disease threats coexist and multiple health influencing factors are intertwined" is demonstrated by the fact that dental caries, obesity myopia and scoliosis have emerged as global public health issues. The problem of diseases co-existing in living things can be resolved by using probiotics. , has gained attention recently due to its probiotic properties, useful traits, and potential medical applications.

Nuclear receptor PPARγ targets GPNMB to promote oligodendrocyte development and remyelination.

Myelin injury occurs in brain ageing and in several neurological diseases. Failure of spontaneous remyelination is attributable to insufficient differentiation of oligodendrocyte precursor cells (OPCs) into mature myelin-forming oligodendrocytes in CNS demyelinated lesions. Emerging evidence suggests that peroxisome proliferator-activated receptor γ (PPARγ) is the master gatekeeper of CNS injury and repair and plays an important regulatory role in various neurodegenerative diseases.

Distribution characteristics of Hg and As in the water-SPM system in the Xiaoqing river estuary and coastal.

Water and suspended particulate matter (SPM) were collected from Xiaoqing Estuary and its adjacent waters in August 2022 to study the spatial distribution and risk assessment of Hg and As. The content of Hg in SPM samples ranged from 4.7152 to 446.

Biohydrogen fermentation from pretreated biomass in lignocellulose biorefinery: Effects of inhibitory byproducts and recent progress in mitigation strategies.

Lignocellulosic biomass (LCB) is expected to play a critical role in achieving the goal of biomass-to-bioenergy conversion because of its wide distribution and low price. Biomass fermentation is a promising method for the sustainable generation of biohydrogen (bioH) from the renewable feedstock. Due to the inherent resistant structure of biomass, LCB needs to be pretreated to improve its digestibility and utilization.

Short-term visual adaptation to body shape induces sustained aftereffect on body size estimation.

Visual adaptation to thin or large bodies was found to shift the subjective body normality towards the adapting body shape. Here we investigated the persistency of such adaptation effect by tracking the timecourse of decay of short-term body size adaptation in young healthy Chinese women. Participants adapted to contracted or expanded body images of unfamiliar female volunteers with a top-up paradigm.

Longitudinal relationship between adverse childhood experiences and depressive symptoms: the mediating role of physical pain.

Background: This study explored the relationship between Adverse Childhood Experiences (ACE), physical pain, and depressive symptoms, and examined the mediating role of pain in the correlation between ACE and depressive symptoms among middle-aged and elderly Chinese (over the age of 45).

Methods: Cox proportional hazards regression models were used to analysis the association between ACE, physical pain, and depressive symptoms. To assess the mediating role of physical pain in the relationship between ACE and depressive symptoms, mediation analysis was conducted.

Occurrence of 'soft flesh' condition induced by Kudoa thyrsites parasite in the Iberian European sardine stock.

European sardine Sardina pilchardus is a commercially valuable coastal pelagic fish species. Spain is one of the largest sardine suppliers in Europe and the Iberian stock is of particular significance. Kudoa parasites are known to infect sardines causing the so-called 'soft flesh' condition; however, data on the occurrence of 'soft flesh' in this sardine stock are limited.

Comprehensive Analysis of the OASTL Gene Family in Potato ( L.) and Its Expression Under Abiotic Stress.

O-acetylserine (thiol) lyase is a pivotal enzyme in plant cysteine biosynthesis, which is crucial for promoting plant growth, development, and resisting abiotic stress. However, the related studies on the potato OASTL gene family (StOASTL) have not been reported. In the present study, we identified 11 members of the StOASTL gene family, conducting a thorough analysis encompassing chromosome distribution, protein physicochemical properties, gene structure, protein-conserved motifs, and gene replication events.

Diterpenoids and Triterpenoids from the Aerial Parts of and Their Biological Activities.

Five undescribed diterpenoids, serranins A-E (-), and four novel triterpenoids, serratic acids A-D (-), along with 32 known terpenoids (-) were isolated from the aerial parts of . The planar structures of - and their relative configurations were established on the basis of extensive spectroscopic analysis. Structurally, compounds - are the first examples of 18,19--ursane -coumaric or ferulic esters, while compounds - further enriched the plant's diterpene profile.

First Report of 'Soft Flesh' Induced by the Parasite Kudoa thyrsites (Myxosporea) in Commercial Codfish From Norway.

Kudoa thyrsites is a myxosporean parasite that infects the skeletal muscle of various teleost fish species globally. Severe infections lead to 'soft flesh' in fish fillets, resulting in food spoilage and subsequent discard. While K.

Boosting transcriptional activities by employing repeated activation domains in transcription factors.

Enhancing the transcriptional activation activity of transcription factors (TFs) has multiple applications in organism improvement, metabolic engineering, and other aspects of plant science, but the approaches remain unclear. Here, we used gene activation assays and genetic transformation to investigate the transcriptional activities of two MYB TFs, PRODUCTION OF ANTHOCYANIN PIGMENT 1 (AtPAP1) from Arabidopsis (Arabidopsis thaliana) and EsMYBA1 from Epimedium (Epimedium sagittatum), and their synthetic variants in a range of plant species from several families. Using anthocyanin biosynthesis as a convenient readout, we discovered that homologous naturally occurring TFs showed differences in the transcriptional activation ability and that similar TFs induced large changes in the genetic program when heterologously expressed in different species.

Revealing the Effects of Mo Doping to Ni on Catalyzing Hydrogenation of Fatty Acids to Fatty Alcohols.

Fatty acid hydrogenation is an important method for the production of fatty alcohols. The combination of Ni and Mo has been reported to be an effective and low-cost catalyst. However, the effect of Mo doping has yet to be fully understood.

Nanoporous High Entropy Alloy Al-Pt-Pd-Ru as an Efficient Catalyst for One-Pot Reductive Amination of Nitroarenes.

High entropy alloys (HEAs) are promising heterocatalysts because of their unique physicochemical properties, but research on HEA-catalyzed tandem reactions is lacking. Moreover, limited research on HEAs for molecular transformation has hindered their development. Herein, an unsupported nanoporous HEA Al-Pt-Pd-Ru (HEANPore) prepared using a top-down dealloying method is reported.

Evaluating CNN Architectures for the Automated Detection and Grading of Modic Changes in MRI: A Comparative Study.

Objective: Modic changes (MCs) classification system is the most widely used method in magnetic resonance imaging (MRI) for characterizing subchondral vertebral marrow changes. However, it shows a high degree of sensitivity to variations in MRI because of its semiquantitative nature. In 2021, the authors of this classification system further proposed a quantitative and reliable MC grading method.

Status and habitat suitability evaluation: A case study of the typical temperate seagrass beds in the Bohai Sea, China.

Seagrass beds serve crucial ecological functions, yet they are facing a severe decline necessitating immediate conservation and restoration efforts. Current assessments of seagrass habitat suitability are insufficient, thus hindering the restoration effects. This study used a combination of field surveys and satellite remote sensing to conduct a three-year monitoring of typical temperate seagrass beds in the Caofeidian and Xingcheng areas of the Bohai Sea.

Evaluation of Single-Event Effect Current-Carrier Mapping Based on Experimental Data.

For single-event radiation damage of power MOSFET devices, this paper aims to establish a statistical analysis method based on external observation (gate/drain current characteristics in irradiation environment) to recognize and evaluate the radiation evolution process and damage mechanism of microscopic physical quantities inside the devices, namely current-carrier (CC) mapping. Firstly, a special data fluctuate-collapse transform analysis method is proposed according to the temporal characteristics of the gate/drain current. Secondly, a carrier dynamic balance ratio based on current data is defined to evaluate the radiation damage degree of the device.

Warming Mitigates Ozone Damage to Wheat Photosynthesis in a FACE Experiment.

Individual effects of elevated ozone (O) and warming on wheat (Triticum aestivum L.) are well documented, their combined effects remain poorly understood. In the present study, we investigated the combined impacts of elevated O (1.

Enantioselective Assembly of Fully Substituted α-Amino Allenoates Through a Mannich Addition and Stepwise [3,3]-σ Rearrangement Sequence.

Chiral fully-substituted allenes are synthetically significant and pivotal building blocks that can engage in diverse transformations toward a variety of bioactive molecules. The enantioselective assembly of these skeletons using readily available reactants offers significant advantages but remains challenging. Herein, an asymmetric formal Michael-type addition of alkynyl imines with the key alkylgold intermediates derived in situ from N-propargylamides is accomplished under gold-complex and chiral quinine-derived squaramide (QN-SQA) synergetic catalysis.