Publications by authors named "Bao Khanh Lai"
Article Synopsis
- SGLT2 inhibitors (SGLT2i), like dapagliflozin and empagliflozin, are diabetes medications that help lower blood sugar by increasing glucose in urine and may influence hormone levels, but their exact effects on insulin and glucagon secretion are unclear.
- The study assessed the effects of SGLT2i on glucose and hormone levels in mice and investigated their action on islet cells using various research techniques, including mRNA analysis and immunodetection.
- Findings showed that SGLT2i increased the plasma glucagon/insulin ratio in fasting mice but did not have a direct effect on insulin and glucagon secretion in isolated islets or change glucagon gene expression
Hypersecretion of glucagon from pancreatic α-cells strongly contributes to diabetic hyperglycemia. Moreover, failure of α-cells to increase glucagon secretion in response to falling blood glucose concentrations compromises the defense against hypoglycemia, a common complication in diabetes therapy. However, the mechanisms underlying glucose regulation of glucagon secretion are poorly understood and likely involve both α-cell-intrinsic and intraislet paracrine signaling.
View Article and Find Full Text PDFThe mechanisms of control of glucagon secretion are largely debated. In particular, the paracrine role of somatostatin (SST) is unclear. We studied its role in the control of glucagon secretion by glucose and K channel blockers, using perifused islets and the in situ perfused pancreas.
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