Publications by authors named "Banthoon Sukphutanan"

Background & Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) are the leading causes of liver disease and are emerging as the main risk factors for primary liver cancer (PLC). However, updated global data on MASH remain scarce.

Methods: This study analyzed data from the Global Burden of Disease (GBD) study between 2000 and 2021 to assess the age-standardized incidence, mortality, and disability-adjusted life years (DALYs) from MASH-associated PLC, stratified by geographical region, sociodemographic index, age, and sex.

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  • * Analysis of Global Burden of Disease Study 2019 data shows a geographical concentration of SUD issues in Europe and the Americas, with males being more affected than females.
  • * The research emphasizes the urgent need for effective policies to address the substantial burden of SUDs among AYAs, particularly focusing on alcohol-related harms like injuries and violence.
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Background: Alcohol is linked to various cancers. While many studies have focused on developed countries, the burden of alcohol-related cancers in developing countries remains underexplored.

Methods: We analyzed data from the Global Burden of Disease Study (2000-2019) to assess mortality and disability-adjusted life years (DALYs) from alcohol-related cancers in low and low-to-middle sociodemographic index (SDI) countries.

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  • * From 2010 to 2019, an estimated 364,700 new cases and 324,100 deaths from primary liver cancer were reported in this region, representing 68% and 67% of global totals, respectively.
  • * Noteworthy trends include rising incidence rates linked to metabolic dysfunction and alcohol-related liver issues, while viral hepatitis remains the top cause, emphasizing the urgent need for targeted healthcare strategies.
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Background And Aims: Inflammatory Bowel Disease (IBD) represents a significant health threat worldwide. However, there are deficiencies in large-scale epidemiological research focusing on these issues, especially among young women. We aim to examine the trend of IBD in young females globally.

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  • - CDI is a widespread healthcare-associated infection that significantly affects the elderly, posing serious health and economic issues, yet detailed data on its impact are scarce.
  • - Using data from the Global Burden of Disease Study 2019, the analysis from 2000 to 2019 showed CDI resulted in about 18,181 deaths and 252,709 disability-adjusted life years (DALYs) among older adults, with the Americas facing the highest burden.
  • - The findings highlight the urgent need for specialized public health strategies to address the rising CDI rates, particularly in high-sociodemographic index (SDI) regions and the Americas.
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Background And Objective: Early-onset pancreatic cancer (EOPC) is associated with poor prognosis and high disease burden. Metabolic risk factors such as diabetes and obesity are considered risk factors of EOPC. Recently, there has been an increasing number of EOPCs worldwide.

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Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) and cardiometabolic conditions affect populations across economic strata. Nevertheless, there are limited epidemiological studies addressing these diseases in low (LICs) and lower-middle-income countries (lower MICs). Therefore, an analysis of the trend of MASLD and cardiometabolic conditions in these countries is necessary.

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  • * Using data from the Global Burden of Disease Study 2019, the study found rising mortality rates from GI cancers related to high body mass index (BMI) in LICs and lower MICs, unlike in wealthier nations where rates have stabilized or decreased.
  • * The findings highlight the growing public health concern of obesity-related GI cancer mortality in LICs and lower MICs, stressing the need for urgent measures to address the obesity epidemic in these regions.
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  • Alcohol consumption is linked to significant health issues worldwide, including alcohol use disorder (AUD), liver disease, and heart disease, contributing to increased disability and mortality rates, especially among lower socio-economic groups.
  • In 2019, AUD had the highest rate of disability-adjusted life years, with liver disease and alcohol-induced heart problems also notable, although some rates showed slight declines.
  • The burden of alcohol-related health complications is rising particularly in low and low-middle income countries, highlighting an urgent need for effective public health strategies to tackle these challenges.
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Background And Aims: The worldwide burden of cancer is increasing in younger populations. However, the epidemiology of primary liver cancer remains understudied in young adults compared to other cancer forms.

Approach And Results: This study analyzed data from the Global Burden of Disease study between 2010 and 2019 to assess the age-standardized incidence, mortality, and disability-adjusted life years associated with primary liver cancer in the young (15-49 y), stratified by region, nation, sociodemographic index, and sex.

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  • The study investigates the significant burden of alcohol-related issues like liver disease and alcohol use disorder (AUD) among young women, a demographic identified as particularly vulnerable compared to men.
  • Utilizing data from the Global Burden of Disease Study 2019, researchers analyzed prevalence, mortality, and disability-adjusted life years of alcohol-associated cirrhosis, liver cancer from alcohol, and AUD in young women, with findings organized by region and sociodemographic factors.
  • Results show that AUD has the highest prevalence rates, followed by alcohol-associated cirrhosis and liver cancer; Central Europe shows the highest burdens, indicating an urgent need for targeted public health strategies to address these issues in young women.
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  • Inflammatory bowel disease (IBD) is increasingly affecting the elderly, with about 10% of cases now occurring in patients over 65, and this demographic shows greater vulnerability to complications compared to younger patients.
  • A study tracked trends in elderly-onset IBD over a decade, revealing that 13% of all IBD cases are now in older adults, with a rise in incidence among males but a decline in females, particularly notable in the Western Pacific region.
  • Despite a decreasing trend in mortality and disability-adjusted life years (DALYs), the highest burden of elderly-onset IBD is concentrated in America and high sociodemographic index (SDI) countries, underscoring the need for improved public health
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