Risk factors of diabetes and hypertension among women in Karnataka.

Background And Aims: The growth in prevalence of diabetes and hypertension has become a major health issue for women in Karnataka. In India, for the first time, the National Family Health Survey has collected information on diabetes and hypertension across the states within India (NFHS-4, 2015-16). Hence there is the need to estimate the prevalence of diabetes and hypertension among women and the associated risk factors using the national represented data.

Economic burden of diabetic patients in India: A review.

The Indian diabetic population is predicted to reach more than 80 million by the year 2030. It indicates that immediate health policy restructuring and investment will be needed if the best use is to be made of scarce health care resources with accompanying economic constraints. The costs of treatment of diabetes exists among the patients of all socioeconomic groups.

Association of Physicians of India: Position Statement on Role of Chirally Pure Molecules in Clinical Practice.

Chirally pure molecules or enantiomers are non-superimposable mirror images of each other with a chiral center (such as carbon, sulphur, nitrogen or phosphorous atom). An equimolar mixture of enantiomers forms a racemate. Chirally pure molecules (single enantiomers) are important in the field of drug discovery as the drug targets such as enzymes and receptors are enantioselective in nature.

The antibacterial agent, moxifloxacin inhibits virulence factors of Candida albicans through multitargeting.

Fluoroquinolines are broad spectrum fourth generation antibiotics. Some of the Fluoroquinolines exhibit antifungal activity. We are reporting the potential mechanism of action of a fluoroquinoline antibiotic, moxifloxacin on the growth, morphogenesis and biofilm formation of the human pathogen Candida albicans.

Activity of Allyl Isothiocyanate and Its Synergy with Fluconazole against Biofilms.

Candidiasis involving the biofilms of is a threat to immunocompromised patients. biofilms are intrinsically resistant to the antifungal drugs and hence novel treatment strategies are desired. The study intended to evaluate the anti- activity of allyl isothiocyanate (AITC) alone and with fluconazole (FLC), particularly against the biofilms.

Human Interferon Regulatory Factor 2 Gene Expression is Induced in Chronic Hepatitis C Virus Infection-A Possible Mode of Viral Persistence.

Background: The interferon regulatory factors (IRFs) are a family of transcription factors known to be involved in the modulation of cellular responses to interferons (IFNs) and viral infection. While IRF-1 acts as a positive regulator, IRF-2 is known to repress IFN-mediated gene expression. The increase in the IRF-1/IRF-2 ratio is considered as an important event in the transcriptional activation of IFN-α gene toward development of the cellular antiviral response.