Publications by authors named "Bansi Sanghvi"
Anti-restriction and anti-modification (anti-RM) is the ability to prevent cleavage by DNA restriction-modification (RM) systems of foreign DNA entering a new bacterial host. The evolutionary consequence of anti-RM is the enhanced dissemination of mobile genetic elements. Homologues of ArdA anti-RM proteins are encoded by genes present in many mobile genetic elements such as conjugative plasmids and transposons within bacterial genomes.
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- The ardA gene in prokaryotes helps mobile genetic elements evade Type I DNA restriction systems, which aids the spread of antibiotic resistance.
- Researchers determined the structure of the ArdA protein from Tn916, revealing it has a unique elongated cylindrical shape resembling DNA and is the largest known DNA mimic.
- ArdA’s ability to mimic DNA allows it to bind and inhibit Type I restriction enzymes, and studies show that ardA from various pathogenic bacteria can function in E. coli with different restriction systems.