Performance of a continuous flow reactor on bio-reducing vanadium with straw.

Vanadium (V) in groundwater could cause a serious threat to the environment and health. Continuous flow reactors were applied to reduce V(V) with straw being a solid carbon. The reduced efficiency of V(V) in the reactor with straw and inoculated sludge reached to 71.

Performance and Enhancement of Various Fillers Guiding Vanadium (V) Bioremediation.

Bioremediation of vanadium (V) pollution in groundwater is an emerging topic. However, knowledge of V in a biogeochemical process is limited and long-term effective removal methods are lacking. V(V) remediation processes by various kinds of auxiliary fillers (maifanite-1, maifanite-2, volcanic rock, green zeolite and ceramsite), agricultural biomass and microbial enhancing were explored in this study.

Optimizing the added ratio of mixed auxiliary packings for enhancing the biological vanadium (V) removal.

Developing sustainable and low-cost bio-reduction technologies is essential for vanadium (V) bioremediation in groundwater. With both agricultural waste (wheat stalk) being a solid carbon source and ceramsite and medical stone being auxiliary packings, V(V) removal was confirmed and optimized in this study. The ratio of ceramsite to medical stone was maintained at 1:3 in Group I, which accomplished a V(V) removal efficiency up to 97.

Corrigendum to "Performance of Distress Thermometer and Associated Factors of Psychological Distress among Chinese Cancer Patients".

[This corrects the article DOI: 10.1155/2020/3293589.].

Biotransformation of natural polyacetylene in red ginseng by .

Background: Fermentation has been shown to improve the biological properties of plants and herbs. Specifically, fermentation causes decomposition and/or biotransformation of active metabolites into high-value products. Polyacetylenes are a class of polyketides with a pleiotropic profile of bioactivity.

Performance of Distress Thermometer and Associated Factors of Psychological Distress among Chinese Cancer Patients.

Objective: We aimed to examine the performance of the distress thermometer (DT) and identify the prevalence and risk factors associated with psychological distress (PD) in heterogeneous cancer patients.

Methods: This cross-sectional study enrolled 1496 heterogeneous cancer patients from the inpatient and outpatient departments. Receiver operating characteristic analysis (ROC) of DT was evaluated against the Hospital Anxiety and Depression Scale-Total (HADS-T ≥15).

A Comprehensive and Modularized Statistical Framework for Gradient Norm Equality in Deep Neural Networks.

The rapid development of deep neural networks (DNNs) in recent years can be attributed to the various techniques that address gradient explosion and vanishing. In order to understand the principle behind these techniques and develop new methods, plenty of metrics have been proposed to identify networks that are free of gradient explosion and vanishing. However, due to the diversity of network components and complex serial-parallel hybrid connections in modern DNNs, the evaluation of existing metrics usually requires strong assumptions, complex statistical analysis, or has limited application fields, which constraints their spread in the community.

Inducing Intermediates in Biotransformation of Natural Polyacetylene and A Novel Spiro-γ-Lactone from Red Ginseng by Solid Co-Culture of Two Gut and The Potential Bioactivity Modification by Oxidative Metabolism.

The ω-hydroxyl-panaxytriol () and ω-hydroxyl-dihydropanaxytriol ()-are rare examples of polyacetylene metabolism by microbial transformation, and these new metabolites (, ) from fermented red ginseng (FRG) by solid co-culture induction of two should be the intermediates of biotransformation of panaxylactone (metabolite ). The metabolic pathway of panaxylactone was also exhibited. The ingredients of red ginseng (RG) also induced the production of rare 6/5/5 tricyclic ring spiro-γ-lactone skeleton ().

A Systematic Review and Meta-analysis of the Distress Thermometer for Screening Distress in Asian Patients with Cancer.

The distress thermometer (DT) is a commonly used tool for screening distress in Asian patients with cancer. However, the optimal cut-off score and discriminative accuracy remain unclear. Hence, this meta-analysis aimed to examine its diagnostic value and optimal cut-off score in Asia.

Five extracellular matrix-associated genes upregulated in oral tongue squamous cell carcinoma: An integrated bioinformatics analysis.

Despite advancements in treatment regimens, the mortality rate of patients with oral tongue squamous cell carcinoma (OTSCC) is high. In addition, the signaling pathways and oncoproteins involved in OTSCC progression remain largely unknown. Therefore, the aim of the present study was to identify specific prognostic marker for patients at a high risk of developing OTSCC.

Coix seed oil ameliorates cancer cachexia by counteracting muscle loss and fat lipolysis.

Background: Cancer cachexia is a cancer-induced multifactorial debilitating syndrome directly accounting for 20% of cancer deaths without effective therapeutic approaches. It is extremely urgent to explore effective anti-cachexia drugs to ameliorate muscle and fat loss in cachexia patients.

Methods: Lewis lung carcinoma bearing C57BL/6 mice were applied as the animal model to examine the therapeutic effect of Coix seed oil (CSO) on cancer cachexia.

Inducing secondary metabolite production from JC-15 by red ginseng medium.

Red ginseng (RG) is one of the most popular herbal medicines and used as a dietary supplement in recent years. The bioactive ingredient in RG can induce the production of novel microbial metabolite from fermented RG. Using the one strain-many compounds strategy, the reinvestigation of the metabolites from JC-15 cultured in red ginseng medium led to the isolation of an unprecedented benzopyran-naphthalene hybrid, daldinsin ) and a new lactone ().

Cancer-related fatigue and biochemical parameters among cancer patients with different stages of sarcopenia.

Purpose: Cancer-related fatigue (CRF) is a pervasive symptom experienced by cancer patients. Sarcopenia has been suggested as a treatment target of CRF. This study aims to assess the differences of CRF and biochemical markers among different stages of sarcopenia which remain poorly delineated.

Potential antihyperlipidemic polyketones from endophytic sp. JC-J7 in .

Eleven new polyketones named diaporthsins A-K (1-11) were isolated from the fermentation of sp. JC-J7. The chemical structures of compounds (1-11) were elucidated by spectroscopic methods including HRESIMS, 2DNMR, NMR and chemical methods.

New azaphilones and tremulane sesquiterpene from endophytic Nigrospora oryzae cocultured with Irpex lacteus.

Five new metabolites belonging to two backbones of pulvilloric acid-type azaphilone and tremulane sesquiterpene were obtained and their structures were determined by spectral analysis. Based on the biogenesis analysis, tremulane sesquiterpenes were obtained from Irpex lacteus by the stimulation of mixed-culture. The antifungal selectivities of metabolites produced by fungus against their co-culture fungus and common pathogens, exhibited competitive interaction of this mix-culture.

New Azaphilones from Co-Cultured with .

In this study, the co-culture of and , the endophytes in the seeds of , were examined for metabolite diversity. Five new azaphilones were isolated, and their structures were determined by spectral analysis. In terms of azaphilones, compound had an unprecedented skeleton, with a bicyclic oxygen bridge.

Development and validation of a clinically applicable score to classify cachexia stages in advanced cancer patients.

Background: Cachexia is a multifactorial syndrome that is highly prevalent in advanced cancer patients and leads to progressive functional impairments. The classification of cachexia stages is essential for diagnosing and treating cachexia. However, there is a lack of simple tools with good discrimination for classifying cachexia stages.

Benzopyran derivatives from endophytic JC-15 in and their bioactivities.

Five new benzopyran derivatives (-) and a new natural product () were isolated from endophytic in and determined as (R)-2,3-dihydro-2,5-dihydroxy-2-methylchromen-4-one (), (2R, 4S)-2,3-dihydro-2-methyl-benzopyran-4,5-diol (), (R)-3-methoxyl-1-(2,6-dihydroxy phenyl)-butan-1-one (), 7-O-α-d-ribosyl-5-hydroxy-2-methyl-4H-chromen-4-one (), 7-O-α-d-ribosyl-2,3-dihydro-5-hydroxy-2-methyl-chromen-4-one (), daldinium A (). These compounds were evaluated for their antimicrobial activity, anti-acetylcholinesterase, nitric oxide inhibition, anticoagulant, photodynamic antimicrobial activities and glucose uptake of adipocytes. Some compounds showed photoactive antimicrobial activities and glucose uptake stimulating activities.

Identification and functional analysis of a potential key lncRNA involved in fat loss of cancer cachexia.

Cancer cachexia is a devastating, multifactorial, and irreversible syndrome characterized by skeletal muscle reduction with or without fat loss. Although much attention has been focused on muscle wasting, fat loss may occur earlier and accelerate muscle wasting in cachexia. The cause of 20% of cancer related death makes it urgent to discover molecular mechanisms behind cancer cachexia.

Phytotoxic, antibacterial, and antioxidant activities of mycotoxins and other metabolites from Trichoderma sp.

A new natural mycotoxin was isolated from the fermentation broth of Trichoderma sp. Jing-8 and the structure was determined as alternariol 1'-hydroxy-9-methyl ether (1), together with twelve known compounds. The structures were elucidated on the basis of their 1D, 2D NMR spectra and mass spectrometric data.

Differences in Symptom Burden Among Cancer Patients With Different Stages of Cachexia.

Context: Cancer patients with cachexia may suffer from significant burden of symptoms and it can severely impair patients' quality of life. However, only few studies have targeted the symptom burden in cancer cachexia patients, and whether the symptom burden differed in different cachexia stages is still unclear.

Objectives: The aims of this study were to evaluate the symptom burden in cancer cachexia patients and to compare the severity and occurrence rates of symptoms among cancer patients with non-cachexia, pre-cachexia, cachexia, and refractory cachexia.

Metabolites from Penicillium sp. Associated with Paris polyphylla.

One new gentisyl alcohol derivative and-seven known compounds were isolated from the culture of Penicillium sp. Their chemical structures were.elucidated by extensive spectroscopic analysis.

Anti-rheumatic drug iguratimod (T-614) alleviates cancer-induced bone destruction via down-regulating interleukin-6 production in a nuclear factor-κB-dependent manner.

Cytokines are believed to be involved in a "vicious circle" of progressive interactions in bone metastasis. Iguratimod is a novel anti-rheumatic drug which is reported to have the capability of anti-cytokines. In this study, a rat model was constructed to investigate the effect of iguratimod on bone metastasis and it was found that iguratimod alleviated cancer-induced bone destruction.