A GALNT3 mutation causing Hyperphosphatemic familial Tumoral calcinosis.

Unlabelled: Hyperphosphatemic Familial Tumoral Calcinosis (HFTC) is an autosomal recessive disorder. This study investigates the etiology of HFTC in offspring from consanguineous parents.

Methods: Clinical assessment, imaging, and direct sequencing were utilized to elucidate the condition.

Low frequency sound stimulation greatly improved the outcome of a refractory postherpetic neuralgia patient with mood and sleep disorder: a case report.

Postherpetic neuralgia (PHN) is a common and severe chronic complication of the herpes zoster (HZ) virus (shingles) involving prolonged pain which may last from weeks to years. Primary treatment involves oral therapies, although few patients experience a pain reduction of greater than 50%. Due to limited effective treatments, symptoms and comorbidities, including physical disability and emotional distress, are recurrent, and interfere with daily activities and sleep.

Extracorporeal Shock Wave Therapy for the Treatment of Osteoarthritis: A Systematic Review and Meta-Analysis.

Background: Osteoarthritis is the most common musculoskeletal disease. Extracorporeal shockwave therapy had shown an effect on osteoarthritis in both some animal experiments and clinical studies, but there was no systematic review to confirm the value of shockwave therapy in the treatment of all types of osteoarthritis and compare it with other traditional therapies (especially traditional Chinese medicine).

Method: PubMed, Medline, the Cochrane Central Register of Controlled Trials, Web of Science, Chinese National Knowledge Infrastructure, WANFANG database, and VIP database were searched up to December 10, 2019, to identify randomized controlled trials comparing shockwave therapy and other treatments for osteoarthritis.

Pain Prevalence and Pain Management in a Chinese Hospital.

BACKGROUND Pain prevalence has been investigation in many developed countries, but integrated information about pain prevalence in Chinese hospitals is lacking. To achieve better pain treatment of hospitalized patients, pain management needs to be investigated. The present descriptive and cross-sectional study was performed to demonstrate the prevalence of pain by comparison with the 4 traditional vital signs, and to investigate pain management in a Chinese teaching hospital.

The Analgesic and Emotional Response to Intravenous Lidocaine Infusion in the Treatment of Postherpetic Neuralgia: A Randomized, Double-Blinded, Placebo-controlled Study.

Objectives: This study evaluated the analgesic efficacy and emotional response to intravenous lidocaine infusion compared with placebo in patients with postherpetic neuralgia (PHN).

Methods: In this randomized, double-blinded study, patients with PHN received 5 mg/kg intravenous lidocaine infusion or placebo. The primary outcome was pain measured by Visual Analogue Scale, Von Frey, and area of allodynia.

The Theoretical Construction of a Classification of Clinical Somatic Symptoms in Psychosomatic Medicine Theory.

Objective: This article adopts the perspective of psychosomatic medicine to present and test a theoretical model of the classification of clinical somatic symptoms. The theoretical model consists of four dimensions: emotional somatic symptoms, biological somatic symptoms, imaginative somatic symptoms, and cognitive somatic symptoms.

Method: A clinical somatic symptom classification scale was developed according to the theoretical model.

Downregulated long non-coding RNA MEG3 in breast cancer regulates proliferation, migration and invasion by depending on p53's transcriptional activity.

Long non-coding RNAs (lncRNAs) was found to play critical roles in tumorigenesis, hence, screen of tumor-related lncRNAs, identification of their biological roles is important for understanding the processes of tumorigenesis. In this study, we identified the expressing difference of several tumor-related lncRNAs in breast cancer samples and found that, MEG3, which is downregulated in non-small cell lung cancer (NSCLC) tumor tissues, is also downregulated in breast cancer samples compared with adjacent tissues. For figuring out the effect of MEG3 in breast cancer cells MCF7 and MB231, we overexpressed MEG3 in these cells, and found that it resulted the inhibition of proliferation, colony formation, migration and invasion capacities by enhancing p53's transcriptional activity on its target genes, including p21, Maspin and KAI1.

The Constellation of Chronic Low Back Pain and Other Subjective Symptoms: Does the View Differ From China?

Study Design: This was a pilot, cross-sectional study. Its site was West China Hospital in Chengdu, Sichuan Province.

Objective: An objective was to explore whether, in China, chronic low back pain (cLBP) characteristically is one symptom among co-occurring subjective symptoms.

Life events, anxiety, social support, personality, and alexithymia in female patients with chronic pain: A path analysis.

Introduction: This study sought to identify a model that explains the relationship between psychosocial factors and chronic pain in female patients, and to explore all of these constructs in a single study and provide a more holistic examination of the overall psychosocial factors that female patients with chronic pain encounter.

Methods: Female patients with chronic pain (n = 147), aged 20-65 (M = 34.9 years, SD = 11.

Advantages of an etiology-based method for treating cancer pain: a case report and literature review.

Unlabelled: The WHO analgesic guidelines for treatment of cancer pain have been proven safe and effective for most patients. However, there is still inadequate analgesia following that guideline based on pain degree.

Case Report: An 82-year-old man with history of right ceruminous gland carcinoma was treated by tumor resection following numerous courses of chemotherapy.

[A clinical trial of ultrasound-guided facet joint block in the lumbar spine to treat facet joint related low back pain].

Objective: To determine the feasibility and clinical efficacy of ultrasound-guided facet joint injection and nerve block in lumbar facet joint for the treatment of facet-joint related low back pain.

Methods: 20 patients with facet-joint pain were randomized into two groups received block blindly (B group) or guided by ultrasound (US group) respectively. The location of needle tip was confirmed by CT in both groups, and the accuracy was computed afterwards.

[Feasibility and accuracy of ultrasound-guided methodology in the examination of lumbar spine facet joints].

Objective: To investigate the feasibility, accuracy of B ultrasound in the examination of joint space of lumbar spine facet joints compared with CT scan.

Methods: Ten healthy adult volunteers were enrolled. The joint space of lumbar facet joints was measured by ultrasound.

[Mechanical hyperalgesia induced by chronic morphine administration in young rats].

Objective: To investigate the effects of chronic morphine administration on pain behaviors in young rats and to explore the mechanisms involved.

Methods: Sixteen SD young rats of 3-4 weeks were randomly divided into control and morphine administration groups. Young rats received saline (1 mL/kg) or morphine (10 mg/kg) subcutaneously.

Do outcomes of acupuncture for back pain differ according to varying sociocultural contexts? The view from China.

Objectives: What are the outcomes of acupuncture for back pain? According to well-regarded trials, acupuncture is little better for back pain than biomedicine, and active acupuncture is no better than sham acupuncture. These trials occurred in the West. Patients are inside the clinic a miniscule amount of time in relation to the time they are outside the clinic and enmeshed in the wider sociocultural context.

[Appraisement of stellate ganglion block therapy for uncertainty statements syndrome with infrared thermography].

We treated 20 patients suffering from uncertainty statements syndrome (USS) with stellate ganglion block (SGB) therapy. The medical infrared thermography was examined before and after the SGB therapy. Analysis on the changes of surface temperature as well as the outcome of the patients was carried out.

West China hospital set of measures in Chinese to evaluate back pain treatment.

Objective: Chinese is the most commonly spoken language in the world, and back pain is as prevalent in China as it is elsewhere. Nevertheless, there is a paucity of measures in Chinese to evaluate back pain treatment. We assemble a set of Chinese measures to evaluate outcomes in diverse domains.

[Peripheral anti-hyperalgesic effect and neurotoxicologic screening of amitriptyline and bupivacaine on sciatic nerve blockade chronically on neuropathic pain in rats].

Objective: To investigate whether the peripheral administration of amitriptyline and bupivacaine produces anti-hyperalgesic effect and to screen the neurotoxicological effect on sciatic nerve blockade in a rat model of neuropathic pain.

Methods: Twenty-four adult male SD rats [weighing (200 +/- 20) g] were made the models of chronic constriction injury (CCI) and randomly divided into 3 groups (n=8) 5 days after operation: group A (amitriptyline), group B (bupivacaine) and group C (normal saline). 0.

[Validating the Oswestry Disability Index in patients with low back pain in Sichuan].

Objective: To test the reliability and validity of the Oswestry Disability Index (ODI) in patients with low back pain in China.

Methods: Eighty six patients (female 51, male 35, average age 39.5 +/- 10.

[Effect of preemptive intrathecal lornoxicam on foot swelling of formalin test in rats].

Objective: To investigate the anti-inflammatory effect of preemptive intrathecal Lornoxicam on foot swelling of formalin test in rats.

Methods: Eighteen healthy male adult Sprague-Dawley (SD) rats (about 250 g) were randomized into 3 groups: intrathecal solvent group (group S, solvent 20 microL), intramuscular Lornoxicam group (group IM, Lornoxicam 300 microg/20 microL) and intrathecal Lornoxicam group (group IT, Lornoxicam 300 microg/20 microL). After measuring the basic volumes of the left hind paws, rats were injected with corresponding solution intrathecally or intramuscularly, and followed by an intra-plantar administration of 100 microL of 5% formalin 10 minutes later.

[Effect of clofibrate on myocardial triglyceride accumulation in female obese Zucker rats].

Objective: To determine the effect of clofibrate on myocardial triglyceride accumulation in female obese Zucker rats and its role in lipotoxic heart disease.

Methods: Twenty four female Zucker rats were divided into four groups: lean rats+vehicle, lean rats+clofibrate, obese rats + vehicle, obese rats+clofibrate. Daily intraperitoneal injection of clofibrate (300 mg/kg) or vehicle (olive oil, 1 mL/kg) was given to the rats for two weeks.

[Peripheral anti-hyperalgesic effect of amitriptyline for sciatic nerve blockade on neuropathic pain of rats].

Objective: To investigate whether the peripheral administration of amitriptyline produces antihyperalgesic effect following the chronic constriction injury (CCI) of the sciatic nerve in rats.

Methods: Forty-eight male CCI rats weighing (220 +/- 20) g were randomly divided into 6 groups (n = 8): group NS, group A2.5, group A5, group A10, group A15.

[Effects of preemptively injected intrathecal lornoxicam on behavior and c-fos protein expression of rat with formalin hurting].

Objective: The objective of this study was to investigate an antinociceptive effect of preemptive intrathecal lornoxicam on behavior and expression of c-Fos protein in the spinal cord of the formalin hurting rats.

Methods: Forty-two healthy male adult SD rats (200-250 g) were randomized into 7 groups. In the normal saline control group (group NS), 20 microL of normal saline was injected intrathecally, which was followed by a subcutaneous administration of 100 microL of normal saline into the hind plantar skin of rats 10 min later.

[Effects of intrathecal lornoxicam on withdrawal thresholds of rats to mechanical and thermal stimuli].

Objective: To assess the effects of intrathecal lornoxicam on the withdrawal thresholds of rats to mechanical and thermal stimuli.

Methods: After approval of the animal ethic committee, 18 healthy male adult rats were randomly allocated on average to receive the intrathecal solvent (Group S) 20 tL, intramuscular lornoxicam (Group IM) 120 microg/20 microL or intrathecal lornoxicam (Group IT) 120 microg/20 microL, and to do the mechanical withdrawal threshold measured by Dynamic Planter Aesthesiometer (Ugo Basile, Italy). Another 18 rats were allocated similarly to do the thermal withdrawal threshold measured by Hargreaves Test (Ugo Basile, Italy).