Publications by authors named "Bangliang Huang"
Article Synopsis
- Glucagon receptor (GCGR) agonism could help reduce liver fat (hepatic steatosis), but the exact mechanism is unclear.
- The protein CD9 is found at lower levels in fatty livers and increases with GCGR activation; it plays a crucial role in managing fat metabolism in the liver.
- Enhancing CD9 levels can improve liver health and reduce fat accumulation, making it a potential target for treating liver fat issues.
The activity of proteinase is reported to correlate with the development and progression of nonalcoholic fatty liver disease (NAFLD). Puromycin-sensitive aminopeptidase (PSA/NPEPPS) is an integral nontransmembrane enzyme that functions to catalyze the cleavage of amino acids near the N-terminus of polypeptides. A previous study suggested that this enzyme acts as a regulator of neuropeptide activity; however, the metabolic function of this enzyme in the liver has not been explored.
View Article and Find Full Text PDFMitochondrial function is essential for bioenergetics, metabolism, and signaling and is compromised in diseases such as proteinuric kidney diseases, contributing to the global burden of kidney failure, cardiovascular morbidity, and death. The key cell type that prevents proteinuria is the terminally differentiated glomerular podocyte. In this study, we characterized the importance of mitochondrial glycerol 3-phosphate dehydrogenase (mGPDH), located on the inner mitochondrial membrane, in regulating podocyte function and glomerular disease.
View Article and Find Full Text PDFCutaneous wound healing is a fundamental biologic and coordinated process, and failure to maintain this process contributes to the dysfunction of tissue homeostasis, increasing the global burden of diabetic foot ulcerations. However, the factors that mediate this process are not fully understood. Here, we identify the pivotal role of dedicator of cytokinesis 5 (Dock5) in keratinocyte functions contributing to the process of skin wound healing.
View Article and Find Full Text PDFAims: To assess the maresin 1 (MaR1) contents in type 2 diabetic patients with or without diabetic foot ulcer and to analyze the association of MaR1 concentrations with several metabolism-related parameters.
Methods: Plasma MaR1 concentrations were analyzed in 96 subjects with normal glucose tolerant (NC, = 43), type 2 diabetes (T2DM, = 40), or diabetic foot ulcer (DFU, = 13). The intravenous glucose tolerance test (IVGTT) and biochemical parameters were measured in all participants.