A hyaluronic acid-modified cyclodextrin self-assembly system for the delivery of β-carotene in the treatment of dry eye disease.

Dry eye disease (DED) is a multifactorial ocular disease, the core mechanism of which is the tear film instability caused by ocular oxidative stress damage and inflammation. Although various pharmaceutical agents are available for DED treatment, their effectiveness is often limited by the eyes' unique biological barriers, and the long-term use of steroid hormones can lead to several adverse effects. This study reported a nano-supramolecular delivery system consisting of a polycyclodextrin (PCD), hyaluronic acid (HA) and the natural compound β-carotene (BC) for the DED treatment.

A Supramolecular Assembly of EGCG for Long-Term Treatment of Allergic Rhinitis.

Allergic rhinitis (AR) is a type-I hypersensitivity disease mediated by immunoglobulin E (IgE). Although antihistamines, glucocorticoids, leukotriene receptor antagonists, and other drugs are widely used to treat AR, the various adverse side effects of long-term use of these drugs should not be ignored. Therefore, more effective and safe natural alternative strategies are urgently needed.

Double-Layer Hydrogel with Glucose-Activated Two-Stage ROS Regulating Properties for Programmed Diabetic Wound Healing.

Slow healing of wounds induces great pain in diabetic patients. However, developing new approaches to promote diabetic wound healing is still one of the toughest challenges in the medical field. Here, we constructed a new double-layer hydrogel to effectively regulate reactive oxygen species (ROS) on the wound and promote diabetic wound healing.

The expression levels of circulating miR-140-3p, miR-130a-3p, and miR-320b as diagnostic biomarkers in acute ischemic stroke.

Plasma miRNAs can characterize several diseases, including acute ischemic stroke (AIS), which is noninvasive and currently affordable in most laboratories worldwide. We aimed to demonstrate plasma miR-140-3p, miR-130a-3p, and miR-320b as diagnostic biomarkers in AIS.GSE110993 and GSE86291 datasets were analyzed to obtain plasma differentially expressed miRNAs between AIS and healthy control subjects (HCs).

Cyclodextrin Metal-Organic Framework as a Broad-Spectrum Potential Delivery Vehicle for the Gasotransmitters.

The important role of gasotransmitters in physiology and pathophysiology suggest employing gasotransmitters for biomedical treatment. Unfortunately, the difficulty in storage and controlled delivery of these gaseous molecules hindered the development of effective gasotransmitters-based therapies. The design of a safe, facile, and wide-scale method to delivery multiple gasotransmitters is a great challenge.

Poly β-Cyclodextrin/Quaternary Ammoniated Chitosan Cryogel with a Porous Structure for Effective Hemostasis.

Uncontrolled bleeding is one of the most important causes threatening human health, but quick hemostasis remains a challenge. We prepared porous cryogels with poly β-cyclodextrin (Pβ-CD) and quaternary ammoniated chitosan (QCs). Pβ-CD acts as a "water-grabbing agent" to assist QCs' ability to absorb and concentrate blood rapidly.

Bioinspired Ultra Tear-Resistant Elastomer with a Slidable Double-Network Structure.

Tear resistance is of vital importance in the fabrication and application of synthetic soft materials. However, the paradox of simultaneously improving the tearing energy and elasticity remains a huge challenge for conventional approaches. Here, inspired by the skin, we successfully constructed an extraordinary tear-resistant, superelastic elastomer by the introduction of nanosized polycyclodextrin into the elastomer network to form a slidable interpenetrate double network structure.

β-Cyclodextrin-Based Poly (Vinyl Alcohol) Fibers for Sustained Release of Fragrances.

Poly (vinyl alcohol)/β-cyclodextrin (PVA/CD) composite fibers are prepared by wet spinning followed by hot stretching. XRD results show that β-CDs are in an amorphous state in fiber, and β-CD can help maintain the fibrous crystal that exists in the composite fiber. The DSC results show that the total crystalline ratio of the composite fibers decreased with the increase of β-CD.

Green Synthesis of Indeno[1,2-b]quinoxalines Using β-Cyclodextrin as Catalyst.

An efficient, mild, and green method was developed for the synthesis of indeno[1,2-b]quinoxaline derivatives via o-phenylenediamine (OPD) and 2-indanone derivatives utilizing -cyclodextrin (-CD) as the supramolecular catalyst. The reaction can be carried out in water and in a solid state at room temperature. -CD can also catalyze the reaction of indan-1,2-dione with OPD with a high degree of efficiency.

Recent Advances of Porous Materials Based on Cyclodextrin.

Porous materials have attracted significant attention because of their rising applications in many fields. Cyclodextrins (CDs) are suitable building units in the fabrication of porous materials owing to their intrinsic nanoporous structure, easy modification, and biocompatibility, which may result in the formation of CD-based organic frameworks (including cyclodextrin metal-organic frameworks (CD-MOFs) and cyclodextrin covalent organic frameworks (CD-COFs)), and CD-based polymer hybrid porous materials. This review focuses on the recent progress in the fabrication and applications of CD-based porous materials with novel structures and functionalities.

Ultrahigh Carbon Dioxide-Selective Composite Membrane Containing a γ-CD-MOF Layer.

Mixed matrix membranes (MMMs) for CO separation have overcome the trade-off between gas permeability and gas selectivity to some extent. However, most MMMs still are prepared in lab- and pilot-scales since the permeability and selectivity of CO are not good enough to reach the economically available requirements. Moreover, the fabrication of few MMMs with good separation performance is time-consuming or need harsh conditions.

Facile Fabrication of an AIE-Active Metal-Organic Framework for Sensitive Detection of Explosives in Liquid and Solid Phases.

Nowadays, the practical applications of metal-organic framework (MOF)-based fluorescence detectors are severely hindered because of the complex synthesis process of linkers or heavy metal contamination. The development of a simple, inexpensive, and environmentally friendly fluorescence sensing system remains a huge challenge. In this study, we designed and synthesized a TPE@γ-CD-MOF-K complex using the facile in situ encapsulation method.

Poly (vinyl alcohol)/β-Cyclodextrin Composite Fiber with Good Flame Retardant and Super-Smoke Suppression Properties.

Fibers with good flame retardant (FR) and smoke suppression performances are highly desirable for the purpose of eliminating fire hazard. This study developed a novel FR fiber by wet-spinning poly (vinyl alcohol)/β-cyclodextrin (PVA/βCD) composite fiber and crosslinking it with hexamethylene diisocyanate (HDI). βCDs showed good compatibility with PVA matrix, and the resulting PVA/CD/HDI fibers showed mechanical strength at the same level as natural cotton fiber.

Amino-Functionalized β-Cyclodextrin to Construct Green Metal-Organic Framework Materials for CO Capture.

The adsorption of CO by conventional liquid alkanolamine adsorbents does not meet the requirements for green-friendly development in industrial applications. In this work, we constructed NH-β-CD-MOF for the first time through the amino-functionalization of the lowest-priced, readily available, and biocompatible β-CD. Subsequently, the samples were characterized by single-crystal X-ray diffraction, powder X-ray diffraction, scanning electron microscopy, differential scanning calorimetry, thermogravimetric analysis, elemental analysis, and N adsorption/desorption.

Functional materials with self-healing properties: a review.

Self-healing materials (SHMs) have been a research hot topic in recent years owing to their greatly improved longevity and safety in practical applications. Recently, research on SHMs has gradually expanded from structural materials to functional materials. Functional materials with self-healing properties (FMSH) require simultaneous repairing not only of the mechanical properties but of the functionalities from damaged cracks or wounds.

Facile stabilization of a cyclodextrin metal-organic framework under humid environment hydrogen sulfide treatment.

Increasing resistance to humid environments is a major challenge for the application of γ-CD-K-MOF (a green MOF) in real-world utilisation. γ-CD-K-MOF-HS with enhanced moisture tolerance was obtained by simply treating MOF with HS gas. XPS, Raman and TGA characterizations indicated that the HS molecules coordinated with the metal centers in the framework.

Reusable Xerogel Containing Quantum Dots with High Fluorescence Retention.

Although various analytical methods have been established based on quantum dots (QDs), most were conducted in solution, which is inadequate for storage/transportation and rapid analysis. Moreover, the potential environmental problems caused by abandoned QDs cannot be ignored. In this paper, a reusable xerogel containing CdTe with strong emission is established by introducing host⁻guest interactions between QDs and polymer matrix.

β-Cyclodextrin based air filter for high-efficiency filtration of pollution sources.

Airborne particulate matter (PM) pollution has become a serious environmental problem. Thus, there is a need for the development of air filters with satisfactory overall performance. In this paper, we develop a kind of β-cyclodextrin (β-CD) based air filter with high strength, which has not only high filtration efficiency (about 99%) but also good air permeability (the pressure drop is only 45Pa).

Tough Self-Healing Elastomers Based on the Host-Guest Interaction of Polycyclodextrin.

Inspired by animal muscles, we developed a kind of tough elastomers combining high strength and high stretchability with autonomous self-healing capability. A key structural feature is the construction of a double network (DN) connected by the hydrogen bond and host-guest interactions. The first network is the classic elastomer polyacrylate matrix cross-linked by strong hydrogen bonding.

Leeches-Inspired Hydrogel-Elastomer Integration Materials.

Inspired by the functions of leeches, for the first time homogeneous materials integrating hydrogels and elastomers were achieved by free radical polymerization. 2-Methoxyethyl acrylate (MEA) was used as elastomer monomer and Pluronics functionalized with vinyl groups acted as cross-linkers to impart the hydrogel property to the materials. The resulting Pluronic/PMEA gels possess a swelling ratio of about 210% and good water-retaining ability.

Super Tough, Ultrastretchable Hydrogel with Multistimuli Responsiveness.

The research of hydrogels has been increasingly focused on designing an effective energy dissipation structure in recent years. Here, we report a kind of novel supramolecular cross-linker, which was formed by self-assembling amphiphilic block copolymers with guest groups at the end and vinyl-functionalized cyclodextrin (CD) through host-guest interaction. These cross-linkers could dissipate energy effectively since they combined multiple sacrificial mechanisms across multiscales through physical interactions.

Effective Formaldehyde Capture by Green Cyclodextrin-Based Metal-Organic Framework.

A kind of metal-organic framework made from γ-cyclodextrin (γ-CD) and potassium ions were explored as excellent formaldehyde (HCHO) absorbents. The adsorption capacity and speed of γ-CD-MOF-K are both about 9 times higher than those of activated carbon, which are attributed to the porous structure and synergistic effect of hydrogen bonding and host-guest interactions.

Electromagnetic Wave Absorption Coating Material with Self-Healing Properties.

Electromagnetic wave absorption coatings can effectively minimize electromagnetic radiation and are widely used in the military and civil field. However, even small scratches on the coating can lead to a large decline of absorption ability and bring serious consequences. To enhance the lifetime of electromagnetic wave absorbing coating, a kind of self-healing electromagnetic wave absorbing coating is developed by introducing host-guest interactions between the absorbing fillers and polymer matrix.

Shape Memory Polymers Based on Supramolecular Interactions.

Shape memory polymers (SMPs), with the capability to change from one or more temporary shapes to predetermined shapes in response to an external stimulus, have attracted much interest from both academia and industries. When introducing supramolecular interactions that have been featured as dynamic and reversible into the design of novel SMPs, intriguing and unique functionalities have been engendered and thereby broaden the potential applications of the SMPs to new territories. In this review, we summarize recent progress made in SMPs based on supramolecular interactions, provide insight into the material design and shape memory mechanism, elucidate and evaluate their properties and performance, and point out opportunities and applications of SMPs.

Semi-IPNs with Moisture-Triggered Shape Memory and Self-Healing Properties.

Moisture or water has the advantages of being green, inexpensive, and moderate. However, it is challenging to endow water-induced shape memory property and self-healing capability to one single polymer because of the conflicting structural requirement of the two types of materials. In this study, this problem is solved through introducing two kinds of supramolecular interactions into semi-interpenetrating polymer networks (semi-IPNs).