BUDDY: molecular formula discovery via bottom-up MS/MS interrogation.

A substantial fraction of metabolic features remains undetermined in mass spectrometry (MS)-based metabolomics, and molecular formula annotation is the starting point for unraveling their chemical identities. Here we present bottom-up tandem MS (MS/MS) interrogation, a method for de novo formula annotation. Our approach prioritizes MS/MS-explainable formula candidates, implements machine-learned ranking and offers false discovery rate estimation.

Effect of ethanol pre-fermentation on organic load rate and stability of semi-continuous anaerobic digestion of food waste.

This study investigated the effects of ethanol pre-fermentation on the organic load rate (OLR) and stability of single-phase semi-continuous anaerobic digestion system of food waste. Results revealed that the pre-fermentation group tolerated higher OLR, with a maximum OLR of 5.5 g-VS·L·d.

The mediating and moderating effects of resilience on the relationship between perceived stress and depression in heroin addicts.

The purpose of this study was to examine the mediating and moderating roles of resilience on the relationship between perceived stress and depression among heroin addicts. A total of 138 heroin addicts completed the measures of perceived stress, resilience, and depression. Correlation analysis indicated that perceived stress was positively associated with depression.

The prevalence of anxiety on the empty-nest elders in China.

This study aims to review the pooled prevalence of anxiety disorders among empty-nest elderly in China. Nine studies and 4245 empty-nest elders in China were included in this meta-analysis. A combined effect size with 95 percent confidence intervals was calculated to indicate the magnitude of the effect.