Promotion of angiogenesis and suppression of inflammatory response in skin wound healing using exosome-loaded collagen sponge.

Effectively promoting skin wound healing remains a significant challenge in the medical field. Although stem cell-derived exosomes show potential in tissue regeneration, their local delivery and sustained release face challenges. To address these issues, we developed a collagen sponge based on type I and recombinant humanized type III collagen.

Divergent Proteomic Profiles and Uptake Mechanisms of Exosomes Derived from Human Dental Pulp Stem Cells, Endothelial Cells, and Fibroblasts.

Effective intercellular communication is crucial for tissue repair and regeneration, with exosomes playing a key role in mediating these processes by transferring proteins, lipids, and nucleic acids between cells. This study explored the mechanisms underlying the uptake of exosomes derived from human dental pulp stem cells (hDPSCs), human umbilical vein endothelial cells (HUVECs), and human fibroblasts (HFBs). Our findings revealed that hDPSCs exhibited the greatest capacity for exosome uptake across all three cell types.

Human dental pulp stem cell-derived exosomes decorated titanium scaffolds for promoting bone regeneration.

Exosomes, nanoscale extracellular vesicles crucial for intercellular communication, hold great promise as a therapeutic avenue in cell-free tissue regeneration. In this study, we identified and utilized exosomes to adorn anodized titanium scaffolds, inducing osteogenic differentiation in human dental pulp stem cells (hDPSCs). The osteogenesis of hDPSCs was stimulated by exosomes derived from hDPSCs that underwent various periods of osteogenic differentiation.

Osteogenic properties of bioactive titanium in inflammatory environment.

Objectives: It is very important that the effects of surface modified titanium on osteogenic differentiation of bone marrow mesenchymal stem cells in the process of bone regeneration. The bio-function of modified titanium could be affected by the inflammatory micro-environment. The aim of this study was to investigate the effects of modified titanium on osteogenic differentiation in the inflammatory conditions and the osteogenic properties of the modified titanium dental implant in vivo.

A study on the antibacterial property and biocompatibility of ramie fiber.

Ramie fiber (RF) has excellent tensile strength and breathability, making it a promising material for biomedical applications. However, few studies on the antibacterial properties and biocompatibility of RF have been reported. This study aimed to investigate the antibacterial property and biocompatibility of RF with bacteria and fibroblasts.

The response of bioactive titanium surfaces with different structure to UVC-irradiation to eliminate the negative effect on biological properties during aging time.

The biological aging of titanium implants affects the service lifetime negatively in clinical applications, and Ultraviolet (UV) irradiation is an applicable method to overcome the biological aging. This study investigated the changes in surface characteristics and biological properties of bioactive titanium surfaces with different structure and topography after Ultraviolet C (UVC) irradiation. The bioactive titanium surfaces were prepared by anodizing (AO), sandblasting and acid-etching (SLA), acid-alkali etching (AA), alkali-heat etching (AH) methods.

Novel dental implant modifications with two-staged double benefits for preventing infection and promoting osseointegration and .

Peri-implantitis are a major problem causing implant failure these days. Accordingly, anti-infection during the early stage and subsequent promotion of osseointegration are two main key factors to solve this issue. Micro-arc oxidation (MAO) treatment is a way to form an oxidation film on the surface of metallic materials.

Dual modulation of crystallinity and macro-/microstructures of 3D printed porous titanium implants to enhance stability and osseointegration.

The macro architecture and micro surface topological morphology of implants play essential roles in bone tissue regeneration. 3D printing technology provides enormous advantages for the rapid fabrication of personalized bone tissue repair implants. This study presents a demonstration of dual-modulation (DM) 3D printed porous titanium implants to enhance stability and osseointegration.

Effects of statherin on the biological properties of titanium metals subjected to different surface modification.

The failure of dental implants is usually caused by bacteria infection, poor bioactivity and biocompatibility. It is a common phenomenon clinically. Statherin, a salivary protein, plays a crucial role of mediator between materials and cells/bacteria.

Study on microstructure, microhardness, bioactivity, and biocompatibility of La O -containing bioceramic coating doping SiO fabricated by laser cladding.

To solve the lack of strength of calcium phosphate ceramic coatings in load-bearing applications, gradient Ca-P bioceramic coatings doped with La O and SiO are fabricated by laser cladding on Ti-6Al-4 V. The effect of SiO on microstructure, microhardness, bioactivity, and biocompatibility of coatings was investigated. The experimental results illustrate that the coating doped with La O and SiO has excellent metallurgical bonding.

[Advances in titanium dental implant surface modification].

Titanium dental implants have wide clinical application due to their many advantages, including comfort, aesthetics, lack of damage to adjacent teeth, and significant clinical effects. However, the failure of osseointegration, bone resorption, and peri-implantitis limits their application. Physical-chemical and bioactive coatings on the surface of titanium implants could improve the successful rate of dental implants and meet the clinical application requirements.

[Expert consensus on biomechanical research of dental implant].

Current biomechanical research of dental implants focuses on the mechanical damage and enhancement mechanism of the implant-abutment interface as well as how to obtain better mechanical strength and longer fatigue life of dental implants. The mechanical properties of implants can be comprehensively evaluated by strain gauge analysis, photo elastic stress analysis, digital image correlation, finite element analysis, implant bone bonding strength test, and measurement of mechanical properties. Finite element analysis is the most common method for evaluating stress distribution in dental implants, and static pressure and fatigue tests are commonly used in mechanical strength test.

[A review of peri-implant microbiology].

Dental implants represent the majority of treatment strategies used to replace missing teeth. However, peri-implant diseases caused by disturbance in peri-implant microbiological balance are among the reasons for implant failure. Since the 1980s, peri-implant microorganisms have been a hot research topic in dental microbiology.

[Criteria for success in dental implants].

With the comprehensive application and development of implant dentistry in recent years, multi-institutional data have supported a large number of clinical research findings. A consensus was gradually reached on the evaluation of the state and effect of implants and types of indicators that were selected after restoration. This study aims to examine the frequently used criteria to define treatment success in implant dentistry.

Effect of magnesium on reducing the UV-induced oxidative damage in marrow mesenchymal stem cells.

Oxidative stress could cause damage to lipids, proteins and DNA, which is induced by the imbalance between the production of reactive oxygen species (ROS) and the biological system ability to counteract or detoxify their harmful effects. The oxidative stress damage significantly contributes to a number of diseases. Magnesium (Mg) is endowed with a novel function of removing excess ROS by releasing H during the degradation.

The controllable lanthanum ion release from Ca-P coating fabricated by laser cladding and its effect on osteoclast precursors.

Several studies have suggested that rare earth oxides can improve properties of bioceramic coating, and bone resorption of osteoclast can be inhibited by rare earth ion releasing certain concentration. However, the effects of lanthanum ion (La) released from Ca-P coating on osteoclast precursors is not clear. In this work, LaO-doped gradient bioceramic coatings were fabricated on Ti alloy (Ti-6Al-4V) by laser cladding with mixed powders of CaHPO·2HO, CaCO and LaO.

Surface modification of ultrahigh molecular weight polyethylene by plasma-induced in-situ grafting with vinyl triethoxysilane.

Ultrahigh molecular weight polyethylene (UHMWPE) is an excellent material with high performance, but it is very difficult to covalently introduce functional groups on its surface owing to its inherently inert structure, which constrains its further application. In this study, vinyl triethoxysilane (VTEOS) containing hydrolysable alkoxyl groups was in situ grafted on UHMWPE by air plasma treatment. The plasma treatment conditions for VTEOS grafting were optimized.

Regulating the osteogenic function of rhBMP 2 by different titanium surface properties.

Bone morphogenetic protein 2 (BMP-2) is important for regulating the osteogenic differentiation of mesenchymal stem cells and the response of bone tissue. It adsorbs on the surface of biomedical implants immediately and plays a role of mediator between the materials surfaces and the host cells. Studies usually connect the material surface properties and the new bone formation directly.

On the antitumor properties of biomedical magnesium metal.

H is a therapeutic agent for tumors because it could scavenge free radicals, which is one of the causes for this disease in the human body. Biomedical magnesium (Mg) could release H in the biodegradation process, thus it might have antitumor properties. In this study, Mg metal (P-Mg) was subjected to anodic oxidation plus heat treatment to get AO-HT-Mg covered with MgO.

Magnesium metal--a potential biomaterial with antibone cancer properties.

Reactive oxygen plays an important role in the pathogenesis of many serious illnesses, including bony cancer. Recently, it has been suggested that hydrogen (H2), a selective antioxidant, can effectively scavenge free radicals. Biomedical magnesium (Mg) used for bone defect repair in the surgery of bony cancer could release H2 because of the degradation, so Mg might have the potential to prevent bony cancer from metastasis and recurrence.

Surface modification of ultrahigh molecular weight polyethylene by the poly(ethylene glycol)-grafted method and its effect on the adsorption of proteins and the adhesion of blood platelets.

With the help of a silane coupling agent, poly(ethylene glycol) (PEG), a well-biocompatable agent, was grafted onto the surface of ultrahigh molecular weight polyethylene (UHMWPE) by ultraviolet initiation. Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy analysis proved the success of PEG grafting. Water contact angle measurement showed that the modified UHMWPE was obviously improved in surface hydrophilicity and thermogravimetric analysis result showed that its thermostability did not decline even it was pretreated by strong acids.

Anti-inflammatory properties of bioactive titanium metals.

Anti-inflammatory properties of bioactive titanium metals prepared by anodic oxidation (AO-Ti) and alkali-heat (AH-Ti) treatments were studied by bacterial adhesion test and myeloperoxidase (MPO) activity assay methods. The bioactivities of the metals were also evaluated by apatite formation ability and osteoblasts culture experiments. Both metals could induce apatite formation and support osteoblasts proliferation.

Bioactive nano-titania ceramics with biomechanical compatibility prepared by doping with piezoelectric BaTiO(3).

Piezoelectric BaTiO(3) was employed as a crystal growth inhibitor additive for the preparation of bioactive nano-titania ceramics in this study. It is found that the additive could significantly inhibit nano-titania ceramic crystal growth during the pressureless sintering process. This inhibitory ability has great effects on the mechanical properties and bioactivities of the nano-titania ceramics, making it possible to obtain bioactive nano-titania ceramics with mechanical properties analogous to human bone.

Collagen nanofilm immobilized on at surfaces by electrodeposition method.

A simple electrodeposition method is presented for the preparing of collagen nanofilms (EAT) on anodic oxidized titanium surfaces (AT). The nanofilms were observed by scanning electron microscopy and atomic force microscopy. Functional TiOx layers with anionic groups of --PO(4), --SO(4) and --OH were investigated on the AT surface by X-ray photoelectron spectroscopy; X-ray diffraction results indicated that the AT surface was composed mainly of anatase and rutile.

Effects of hydroxyapatite additive content on the bioactivity and biomechanical compatibility of bioactive nano-titania ceramics.

Bioactive nano-titania ceramics with excellent biomechanical compatibility and bioactivity were prepared by using hydroxyapatite (HA) additive as grain growth inhibitor with different contents. After sintered at 1000 degrees C with pressureless sintering method, the grain size of nano-titania ceramic was less than 70 nm. Mechanical test results showed that compressive strengths of the nano ceramics were from 137.