The Analgesic and Emotional Response to Intravenous Lidocaine Infusion in the Treatment of Postherpetic Neuralgia: A Randomized, Double-Blinded, Placebo-controlled Study.

Objectives: This study evaluated the analgesic efficacy and emotional response to intravenous lidocaine infusion compared with placebo in patients with postherpetic neuralgia (PHN).

Methods: In this randomized, double-blinded study, patients with PHN received 5 mg/kg intravenous lidocaine infusion or placebo. The primary outcome was pain measured by Visual Analogue Scale, Von Frey, and area of allodynia.

[A clinical trial of ultrasound-guided facet joint block in the lumbar spine to treat facet joint related low back pain].

Objective: To determine the feasibility and clinical efficacy of ultrasound-guided facet joint injection and nerve block in lumbar facet joint for the treatment of facet-joint related low back pain.

Methods: 20 patients with facet-joint pain were randomized into two groups received block blindly (B group) or guided by ultrasound (US group) respectively. The location of needle tip was confirmed by CT in both groups, and the accuracy was computed afterwards.

[Feasibility and accuracy of ultrasound-guided methodology in the examination of lumbar spine facet joints].

Objective: To investigate the feasibility, accuracy of B ultrasound in the examination of joint space of lumbar spine facet joints compared with CT scan.

Methods: Ten healthy adult volunteers were enrolled. The joint space of lumbar facet joints was measured by ultrasound.

[Mechanical hyperalgesia induced by chronic morphine administration in young rats].

Objective: To investigate the effects of chronic morphine administration on pain behaviors in young rats and to explore the mechanisms involved.

Methods: Sixteen SD young rats of 3-4 weeks were randomly divided into control and morphine administration groups. Young rats received saline (1 mL/kg) or morphine (10 mg/kg) subcutaneously.

[Validating the Oswestry Disability Index in patients with low back pain in Sichuan].

Objective: To test the reliability and validity of the Oswestry Disability Index (ODI) in patients with low back pain in China.

Methods: Eighty six patients (female 51, male 35, average age 39.5 +/- 10.

[Effect of preemptive intrathecal lornoxicam on foot swelling of formalin test in rats].

Objective: To investigate the anti-inflammatory effect of preemptive intrathecal Lornoxicam on foot swelling of formalin test in rats.

Methods: Eighteen healthy male adult Sprague-Dawley (SD) rats (about 250 g) were randomized into 3 groups: intrathecal solvent group (group S, solvent 20 microL), intramuscular Lornoxicam group (group IM, Lornoxicam 300 microg/20 microL) and intrathecal Lornoxicam group (group IT, Lornoxicam 300 microg/20 microL). After measuring the basic volumes of the left hind paws, rats were injected with corresponding solution intrathecally or intramuscularly, and followed by an intra-plantar administration of 100 microL of 5% formalin 10 minutes later.

[Effect of clofibrate on myocardial triglyceride accumulation in female obese Zucker rats].

Objective: To determine the effect of clofibrate on myocardial triglyceride accumulation in female obese Zucker rats and its role in lipotoxic heart disease.

Methods: Twenty four female Zucker rats were divided into four groups: lean rats+vehicle, lean rats+clofibrate, obese rats + vehicle, obese rats+clofibrate. Daily intraperitoneal injection of clofibrate (300 mg/kg) or vehicle (olive oil, 1 mL/kg) was given to the rats for two weeks.

[Effects of preemptively injected intrathecal lornoxicam on behavior and c-fos protein expression of rat with formalin hurting].

Objective: The objective of this study was to investigate an antinociceptive effect of preemptive intrathecal lornoxicam on behavior and expression of c-Fos protein in the spinal cord of the formalin hurting rats.

Methods: Forty-two healthy male adult SD rats (200-250 g) were randomized into 7 groups. In the normal saline control group (group NS), 20 microL of normal saline was injected intrathecally, which was followed by a subcutaneous administration of 100 microL of normal saline into the hind plantar skin of rats 10 min later.

[Effects of intrathecal lornoxicam on withdrawal thresholds of rats to mechanical and thermal stimuli].

Objective: To assess the effects of intrathecal lornoxicam on the withdrawal thresholds of rats to mechanical and thermal stimuli.

Methods: After approval of the animal ethic committee, 18 healthy male adult rats were randomly allocated on average to receive the intrathecal solvent (Group S) 20 tL, intramuscular lornoxicam (Group IM) 120 microg/20 microL or intrathecal lornoxicam (Group IT) 120 microg/20 microL, and to do the mechanical withdrawal threshold measured by Dynamic Planter Aesthesiometer (Ugo Basile, Italy). Another 18 rats were allocated similarly to do the thermal withdrawal threshold measured by Hargreaves Test (Ugo Basile, Italy).

[Analgesic actions after local peripheral administration of Lornoxicam in a model of formalin test in the rat].

Objective: To investigate analgesic actions after local peripheral administration of Lornoxicam in an animal model of formalin test.

Methods: Male Spague-Dawley rats were randomly divided into 3 groups, namely the control, the ipsilateral and the contralateral groups. Each group consisted of 8 rats.

[Effect of clonidine on rat's behavior response and spinal nitric oxide in formalin test].

Objective: To assess the effect of Clonidine on SD rat's behavior response and spinal nitric oxide in the formalin test.

Methods: The effects of Clonidine (Clo), L-arginine(L-Arg), and NG-nitro-L-arginine (L-NAME) on the flinching and licking time of rats in the formalin test were assessed using the model of formalin-induced hyperalgia.

Results: The flinching and licking time of group Clo was shorter (38.