Corn Silk Polysaccharides with Different Carboxyl Contents Reduce the Oxidative Damage of Renal Epithelial Cells by Inhibiting Endocytosis of Nano-calcium Oxalate Crystals.

Objective: Renal epithelial cell injury and cell-crystal interaction are closely related to kidney stone formation.

Methods: This study aims to explore the inhibition of endocytosis of nano-sized calcium oxalate monohydrate (nano-COM) crystals and the cell protection of corn silk polysaccharides (CCSPs) with different carboxyl contents (3.92, 7.

Cell Protection and Crystal Endocytosis Inhibition by Sulfated Polysaccharides Against Nano-COM-Induced Oxidative Damage in Renal Epithelial Cells.

: The damage to renal tubular epithelial cells is closely related to the formation of kidney stones. At present, research on drugs that can protect cells from damage remains limited. : This study aims to explore the protective effects of four different sulfate groups (-OSO ) of polysaccharides (SLPs) on human kidney proximal tubular epithelial (HK-2) cells and determine the difference in the endocytosis of nano-sized calcium oxalate monohydrate (COM) crystals before and after protection.

Regulatory Effects of Damaged Renal Epithelial Cells After Repair by Polysaccharides with Different Sulfation Degree on the Calcium Oxalate Crystal-Cell Interaction.

Background: The interaction between urinary microcrystals and renal epithelial cells is closely related to kidney stone formation. However, the mechanism of cell state changes that affect crystal-cell interaction remains unclear.

Methods: This study investigated the relationship between the sulfate group (-OSO ) content in polysaccharide (PYP) and the ability to repair damaged cells, as well as the changes in cell adhesion and endocytosis of nano-calcium oxalate monohydrate (COM) crystals before and after PYP repair of damaged renal tubular epithelial cells.