Native Endophytes of -Mediated Biotransformation Reduces Toxicity of Celastrol.

Celastrol (), obtained from the roots of Hook F., is most likely to become an antitumor drug, but with severe cytotoxicity. Due to the lack of modifiable sites in the structure of celastrol, the structural diversity of the modified products obtained by synthesis in the previous studies is insufficient, which hinders the pace of its patent medicine.