Publications by authors named "Bang-Li Hu"
Article Synopsis
- - The study investigates the effectiveness and safety of combining fruquintinib, a drug for chemotherapy-resistant metastatic colorectal cancer (mCRC), with immune checkpoint inhibitors (ICIs) in patients after conventional chemotherapy.
- - Data from 72 mCRC patients showed that those treated with the combination therapy had better objective response rates, disease control rates, overall survival, and progression-free survival than those receiving fruquintinib alone.
- - The combination therapy's side effects were manageable, and albumin levels were noted as a significant prognostic marker for survival outcomes in these patients.
Background: Angiogenesis plays a pivotal role in colorectal cancer (CRC), yet its underlying mechanisms demand further exploration. This study aimed to elucidate the significance of angiogenesis-related genes (ARGs) in CRC through comprehensive multi-omics analysis.
Methods: CRC patients were categorized according to ARGs expression to form angiogenesis-related clusters (ARCs).
Article Synopsis
- This study investigates the role of a novel circular RNA, hsa_circ_101303, in colorectal cancer (CRC) to understand how it contributes to the disease and its potential as a diagnostic marker.
- Researchers found that hsa_circ_101303 is significantly overexpressed in CRC tissues, correlating with advanced stages of the disease, and its levels in plasma could help diagnose CRC with reasonable accuracy.
- A competing endogenous RNA (ceRNA) network was constructed that highlights the interactions between hsa_circ_101303, specific miRNAs, and target genes, providing insights into the regulatory mechanisms of colorectal cancer.
LncRNAs have shown to regulate ferroptosis in colorectal cancer (CRC), but the mechanism remains largely unknown. This study unveiled the mechanism of SNHG4 underlying ferroptosis in CRC. RNA-seq and RT-PCR assay confirmed SNHG4 was decreased after Erastin treatment in CRC cells.
View Article and Find Full Text PDFOxaliplatin resistance poses a significant challenge in colorectal cancer (CRC) therapy, necessitating further investigation into the underlying molecular mechanisms. This study aimed to elucidate the regulatory role of SNHG4 in oxaliplatin resistance and ferroptosis in CRC. Our findings revealed that treatment with oxaliplatin led to downregulation of SNHG4 expression in CRC cells, while resistant CRC cells exhibited higher levels of SNHG4 compared to parental cells.
View Article and Find Full Text PDFBackground: The tumor microenvironment (TME) plays a crucial role in tumorigenesis, progression, and therapeutic response in many cancers. This study aimed to comprehensively investigate the role of TME in colorectal cancer (CRC) by generating a TMEscore based on gene expression.
Methods: The TME patterns of CRC datasets were investigated, and the TMEscores were calculated.
Article Synopsis
- * Five miRNAs were found to have altered expression in CRC tissues, with two being upregulated (miR-595 and miR-1237) and three downregulated (miR-126, miR-139, and miR-143).
- * While these miRNAs were linked to CRC pathogenesis, they were not correlated with cancer stage, and using a combination of them improved diagnostic accuracy for CRC compared to using a single miRNA.
Background: Oxaliplatin-based chemotherapy is the first-line treatment for colorectal cancer (CRC). Long noncoding RNAs (lncRNAs) have been implicated in chemotherapy sensitivity. This study aimed to identify lncRNAs related to oxaliplatin sensitivity and predict the prognosis of CRC patients underwent oxaliplatin-based chemotherapy.
View Article and Find Full Text PDFSPINK4 promotes colorectal cancer cell proliferation and inhibits ferroptosis.
BMC Gastroenterol
April 2023
Background: Little is known about the role of serine peptidase inhibitor Kazal type 4 (SPINK4) in colorectal cancer (CRC) and ferroptosis. Therefore, this study aimed to determine the effect of SPINK4 on CRC pathogenesis and ferroptosis.
Methods: SPINK4 expression was analyzed in public datasets and examined using immunohistochemistry.
Background: Tumor-infiltrating immune cells (TIICs) are associated with chemotherapy response. This study aimed to explore the prognostic value of a TIIC-related tumor microenvironment score (TMEscore) in patients with colorectal cancer (CRC) who underwent chemotherapy and construct a TMEscore-related gene signature to determine its predictive value.
Methods: Gene profiles of patients who underwent fluoropyrimidine-based chemotherapy were collected, and their TIIC fractions were calculated and clustered.
Gastric cancer (GC) is one of the most common gastrointestinal malignancies. Ferroptosis is a new type of peroxidation-driven and iron-dependent cell death. However, the biological functions and exact regulatory mechanisms of ferroptosis in GC remain elusive.
View Article and Find Full Text PDFBackground: Hypoxia plays a significant role in the pathogenesis of pancreatic cancer, but the effect of hypoxia-related genes in pancreatic cancer remains to be elucidated. This study aimed to identify hypoxia-related genes related to pancreatic cancer and construct a prognostic signature.
Methods: Pancreatic cancer datasets were retrieved from TCGA database.
Cancer stem cells play crucial roles in colorectal cancer (CRC) tumorigenesis and treatment response. This study aimed to determine the value of the mRNA stemness index (mRNAsi) in CRC and introduce a stemness-related classification to predict the outcome of patients. mRNAsi scores and RNA sequence data of CRC patients were analyzed.
View Article and Find Full Text PDFBackground: The detection rate of methylated Septin9 (mSEPT9) in colorectal cancer (CRC) is varied greatly across the studies. This study aimed to evaluate the diagnostic ability of mSEPT9 in CRC, and compare the diagnostic efficacy with fecal immunochemical test (FIT).
Methods: 326 subjects from four centers were prospectively recruited, including 179 CRC and 147 non-CRC subjects.
Background: The role of F-flurodeoxyglucose (F-FDG) positron emission tomography-computed tomography (PET/CT) in colorectal cancer (CRC) remains unclear. This study aimed to explore the association of the maximum standardized uptake value (SUVmax), a parameter of F-FDG PET/CT, with KRAS mutation, the Ki-67 index, and survival in patients with CRC.
Methods: Data of 66 patients with CRC who underwent F-FDG PET/CT was retrospectively collected in our center.
Article Synopsis
- * The study analyzed various datasets and biological samples, finding that while blood levels of might be higher in CRC patients, it does not correlate with CRC progression or prognosis.
- * Overall, the findings suggest that has a notable presence in CRC tissues but does not affect the development stages or survival outcomes for CRC patients.
Article Synopsis
- The study investigates the role of immune cell infiltration and immune-related genes in Crohn's disease (CD) to enhance diagnosis and treatment prediction.
- Researchers analyzed gene expression data to identify key genes and their association with immune cell presence in CD tissues, finding significant differences between CD and normal tissues.
- Certain genes were established as diagnostic and predictive indicators for CD, particularly in assessing patients' response to anti-TNFα therapy.
Background: Cancers located on the right and left sides of the colon have distinct clinical and molecular characteristics. This study aimed to explore the regulatory mechanisms of location-specific long noncoding RNAs (lncRNAs) as competing endogenous RNAs (ceRNAs) in colon cancer and identify potential prognostic biomarkers.
Method: Differentially expressed lncRNAs (DELs), miRNAs (DEMs), and genes (DEGs) between right- and left-side colon cancers were identified by comparing RNA sequencing profiles.
BACKGROUND Natural killer (NK) cells are important for the prognosis of multiple cancers, but their prognostic value remains to be evaluated in patients with gastric cancer. Thus, this retrospective study was conducted at a single center to investigate the association between percentage of NK cells in the peripheral blood and prognosis in patients with gastric cancer. MATERIAL AND METHODS The data of 180 gastric cancer patients were collected.
View Article and Find Full Text PDFCo-expression Network Analysis Reveals Novel Genes Underlying Alzheimer's Disease Pathogenesis.
Front Aging Neurosci
November 2020
: The pathogenesis of Alzheimer's disease (AD) remains to be elucidated. This study aimed to identify the hub genes in AD pathogenesis and determine their functions and pathways. : A co-expression network for an AD gene dataset with 401 samples was constructed, and the AD status-related genes were screened.
View Article and Find Full Text PDFArticle Synopsis
- Plasma heat shock protein 90alpha (Hsp90α) levels were significantly higher in patients with gastric cancer compared to those with gastric inflammatory diseases and healthy individuals.
- The study found a correlation between Hsp90α levels and various tumor biomarkers and immune cells, particularly T cells and B cells, indicating its potential role in cancer diagnostics.
- While Hsp90α showed moderate diagnostic value for gastric cancer, it had limited association with patient survival outcomes, suggesting it may not be useful for prognostic purposes.
The molecular mechanisms underlying colon cancer lesions at different sites are not entirely clear. Herein, we aimed to explore location-specific gene profiles related to the pathogenesis of colon cancer and to identify their function. The robust rank aggregation (RRA) method was used to integrate colon cancer microarray datasets and screen differentially expressed gene (DEG) profiles between left- and right-sided colon cancers.
View Article and Find Full Text PDFBackground: Ferroptosis is a newly discovered type of regulated cell death, the underlying mechanisms of which need to be further illuminated. The regulatory activity of in ferroptosis in colon cancer cells is currently unclear. This study set out to investigate the effect of on ferroptosis in colon cancer cells and determine its underlying mechanism.
View Article and Find Full Text PDFThis study aimed to analyze the prognostic value and clinical significance of mRNA expression and methylation in lung squamous cell carcinoma (LUSC). The mRNA expression and methylation of data of LUSC patients were downloaded from the Broad GDAC Firehose database and analyzed. mRNA expression was downregulated and methylation was upregulated in LUSC tissue.
View Article and Find Full Text PDFPrognostic value of peripheral blood natural killer cells in colorectal cancer.
BMC Gastroenterol
February 2020
Background: The association between natural killer (NK) cells and survival in colorectal cancer (CRC) patients remains controversial. This study aimed to clarify the prognostic value of peripheral blood NK cells in CRC patients.
Methods: A total of 447 CRC patients who underwent radical surgery and chemotherapy were retrospectively analyzed.