Prognosis and clinical relevance of recurrent oral ulceration in Behçet's disease.

There is no way of predicting whether a patient with recurrent oral ulcerations (ROU) will develop Behçet's disease (BD). In the absence of a valid laboratory test to exclude BD, such oral ulcerations result in a diagnostic problem when they occur as the sole and earliest manifestation of disease. We assessed the prognosis of ROU by performing prospective evaluations of 67 patients who had only a history of ROU and were registered at the Behçet's Disease Specialty Clinic at Severance Hospital of Yonsei University, Seoul, Korea.

Regulation of the Saccharomyces cerevisiae DNA repair gene RAD16.

The RAD16 gene product has been shown to be essential for the repair of the silenced mating type loci [Bang et al. (1992) Nucleic Acids Res. 20, 3925-3931].

Electron microscopic observation of erythema nodosum with the eosinophilic infiltration. A case report.

The presence of eosinophils localized within an inflammatory skin lesion of a patient with erythema nodosum has been studied by electron microscopy. Among the intact eosinophils seen in the cellular infiltration, some underwent necrosis and released membrane-bound, free eosinophil granules into the interlobular septa of the subcutaneous fat. Such granules, identified by their central crystalline cores, often showed granular changes with core dissolution and were found scattered in the edematous space between the collagen bundles.

The RAD7 and RAD16 genes, which are essential for pyrimidine dimer removal from the silent mating type loci, are also required for repair of the nontranscribed strand of an active gene in Saccharomyces cerevisiae.

The rad16 mutant of Saccharomyces cerevisiae was previously shown to be impaired in removal of UV-induced pyrimidine dimers from the silent mating-type loci (D. D. Bang, R.

Tick bites in Korea.

Background: Tick bites are dermatoses not commonly encountered in Korea. Recognizing their clinical signs as well as their histopathologic findings is important in making a diagnosis of tick-related dermatoses. The incidence and causative species are different depending on the geographic areas.

Clinical analysis of 40 cases of childhood-onset Behçet's disease.

Behçet's disease is a chronic, relapsing, idiopathic, multi-system condition characterized by mucocutaneous, ocular, gastrointestinal, articular, vascular, urogenital, and neurologic involvement. Usually the onset occurs between 20 and 30 years of age; it is very uncommon in children. We analyzed 40 cases of childhood-onset Behçet's disease.

Persistent erythema infectiosum-like rash as a prodrome of acute lymphocytic leukemia.

A 7-year-old boy had erythema infectiosum with typical manifestations. Over more than 40 days, these lesions showed no sign of regression, and chronic anemia became progressively more severe. Electron microscopic examination performed 20 days after onset showed abnormal Sezary-like lymphocytes.

[Treatment of subcapital fractures of the 4th and the 5th metacarpus. A clinical trial of the results after treatment without immobilization and reposition and a study of the treatment of these fractures at casualty departments in Denmark].

The aim of the study was to evaluate the results of treating subcapitular fractures of the fourth and fifth metacarpal bones with immediate mobilization and without splinting or reduction. Thirty-six such fractures were prospectively treated in this fashion and evaluated clinically. After four weeks only four patients (11.

Clinical study on death in Behçet's disease.

We were able to identify 7 patients who died of Behçet's disease, among 2,200 patients registered at the Behçet's Disease Specialty Clinic of Severance Hospital from November 1983 to October 1992. Six were male and one female. Age of death was 31 to 55 years with the mean age of 39.

New procedure for analysing drug binding data, exemplified by warfarin binding to human serum albumin.

Determination of binding constants for multiple binding of a ligand usually results in highly variable figures. We have found that the variations depend mainly upon cooperativity of ligand binding, and that cooperativity is generally absent on binding to human serum albumin. When this is taken into account it becomes possible to obtain binding constants with only slight variation.

Ultrastructure of endothelial cell necrosis in classical erythema nodosum.

As evidence of vascular involvement in classical erythema nodosum unassociated with Behçet's disease, the occurrence of endothelial cell necrosis based on the development of dark cell degeneration was observed by electron microscopy in the vasculature of the dermis and subcutaneous fat. The incidence of endothelial cell necrosis in all segments of the microcirculatory system was roughly 20% in three of 12 patients. The remaining nine patients showed a very low rate of necrosis, including two patients in whom endothelial cell necrosis was totally absent.

Molecular cloning of RAD16, a gene involved in differential repair in Saccharomyces cerevisiae.

We have cloned the RAD16 gene of Saccharomyces cerevisiae and determined its nucleotide sequence. The gene complements the UV sensitivity of a rad16 mutant and restores the ability to repair the transcriptionally inactive HML alpha locus that is absent in this mutant. Disruption mutants that were constructed using the cloned gene are viable and UV sensitive and show no detectable growth defect.

Hair follicle nevus.

Four cases of hair follicle nevi are described. Hair follicle nevus is an extremely rare hamartoma occurring on the face, which has had no clear histopathologic definition until now. A short review of the clinicopathologic features of this disease is presented.

Acne fulminans and 13-cis-retinoic acid.

We report a case of acne fulminans occurring during treatment with 13-cis-retinoic acid for cystic acne. Continuing the treatment with 13-cis-retinoic acid without systemic steroid eventually cleared the systemic manifestations and skin lesions. We review the literature and discuss its pathogenesis.

Differential recovery of prostacyclin and endothelium-derived relaxing factor after vascular injury.

Differential recovery of prostacyclin and endothelium-derived relaxing factor after vascular injury. Am. J.

Absence of lupus anticoagulants in Behçet's disease.

The presence of a lupus anticoagulant was evaluated in patients with Bechet's disease by the kaolin clotting time method. Four percents (three patients) of 69 patients analyzed were found positive for the lupus anticoagulant. However, no statistically significant association existed between the presence of this antibody and the presence of thrombosis, clinical activity, clinical type, antinuclear antibodies and the positive VDRL test.

Confluent and reticulated papillomatosis: a clinical, histopathological, and electron microscopic study.

The clinical, histopathological, and electron microscopic features of ten patients with confluent and reticulated papillomatosis (CRP) of Gougerot and Carteaud were studied. Histopathologically, hyperkeratosis, decreased granular layer, irregular papillomatosis, and hypermelanosis of the basal layer were present. In an electron microscopic study, we found transitional cells between the stratum granulosum and stratum corneum that were increased in CRP.

Transepidermal elimination of thrombi in three cases of thrombotic angiokeratoma: an incidental histopathologic finding of angiokeratoma.

Transepidermal elimination (TEE) is a well known phenomenon by which foreign or altered constituents are removed from the dermis. A thrombosis in the dilated dermal blood vessels of angiokeratoma is not unusual, hence the term thrombotic angiokeratoma. We recently reviewed the histopathologic findings of previously diagnosed cases of angiokeratoma and found that multiple histologic sections of surgical biopsy materials disclosed changes indicating TEE of thrombi in three cases.

Effects of recombinant human granulocyte colony stimulating factor and granulocyte-monocyte colony stimulating factor on in vitro hemopoiesis in the myelodysplastic syndromes.

We evaluated the effects of recombinant human granulocyte colony stimulating factor (rhG-CSF) and granulocyte-monocyte colony stimulating factor (rhGM-CSF) on the in vitro proliferative, differentiative, and regenerative responsiveness of marrow cells from myelodysplastic syndrome patients (MDS) in comparison to those from normal individuals. Our studies showed decreased primary clonogenicity of myeloid (CFU-GM) and erythroid (BFU-E) hemopoietic progenitor cells from the MDS patients. rhGM-CSF had more potent stimulatory effects than rhG-CSF for MDS marrow CFU-GM growth; no enhanced cellular proliferation in the MDS patients was observed in liquid culture with either rhGM-CSF or rhG-CSF.

Pilar sheath acanthoma--report of a case with review of the literature.

A 52-year-old male presented with a solitary asymptomatic, skin-colored nodule with a central pore on the skin of the left cheek of one year duration. An excisional biopsy was performed. The skin biopsy finding showed the typical histological picture of pilar sheath acanthoma.

Scanning electron microscopy of Malassezia furfur in tinea versicolor.

Morphologic features of Malassezia(M.) furfur in the horny layer from clinical lesions of tinea versicolor were examined by scanning electron microscopy and compared with the appearance of fungus in the horny layer from normal skin and in culture. In skin lesions of tinea versicolor, M.

Assessment of apoptosis of infiltrating lymphocytes in erythema nodosum-like lesions of corticosteroid-treated patients with Behçet's syndrome.

Biopsy specimens of recurrent erythema nodosum-like lesions from corticosteroid-treated and non-treated patients with Behçet's syndrome were examined with the electron microscope to determine the incidence of apoptotic cell death of infiltrating lymphocytes in connective tissue. Apoptosis of infiltrating lymphocytes was detected in all corticosteroid-treated patients, but not in non-treated patients. While part of this phenomenon is undoubtedly due to a direct action of corticosteroids on the lymphocytes themselves, it seems likely that indirect action of the corticosteroids such as inhibition of lymphokine or interleukin production may deprive lymphocytes of proliferative and other stimuli and therefore also play some part in the overall response.

Appearance of membranocystic lesion (Nasu)-like changes in Behçet's syndrome. An electron microscopic study of erythema nodosum-like lesions.

Membranocystic lesion (Nasu)-like changes were seen in the subcutaneous fat tissues of erythema nodosum-like lesions in three of 18 patients with Behçet's syndrome. The membranocystic structures, which were derived from degenerative fat cells with a loss of the cell membrane, were observed in the edematous connective tissues accompanied by fibrin deposition and diapedesis of erythrocytes. Electron microscopic evaluation revealed two different patterns of peculiar membranous structures in the cytoplasm of the degenerative fat cells.