Impact of COVID-19 on emergency department management of stroke and STEMI. A narrative review.

The novel coronavirus of 2019 (COVID-19) has resulted in a global pandemic; COVID-19 has resulted in significant challenges in the delivery of healthcare, including emergency management of multiple diagnoses, such as stroke and ST-segment myocardial infarction (STEMI). The aim of this study was to identify the impacts of the COVID-19 pandemic on emergency department care of stroke and STEMI patients. In this study a review of the available literature was performed using pre-defined search terms, inclusion criteria, and exclusion criteria.

Definitive high-dose, proton-based radiation for unresected mobile spine and sacral chordomas.

Background/purpose: Treatment of spine and sacral chordoma generally involves surgical resection, usually in conjunction with radiation therapy.In certain locations, resection may result in significant neurological dysfunction, so definitive radiation has been used as an alternative to surgery. The purpose of this study is to report the results of high-dose, proton-based definitive radiotherapy for unresected spinal and sacral chordomas.

Detection and cellular localization of lead by electron probe analysis in the diagnosis of suspected lead poisoning in rhesus monkeys.

Lead poisoning of unknown source was diagnosed histologically in 2 rhesus monkeys (Macaca mulatta) by finding acid-fast intranuclear inclusion bodies in the epithelial cells of renal cortical tubules. The presence of lead in the inclusions was determined by scanning electron microscopy/energy dispersive x-ray analysis using sections from paraffin embedded tissues. This observation indicates the usefulness of this technique for the detection and cellular localization of lead in tissues, even from archival material.

Use of coagulum for displaced ureteral calculi.

At the time of distal ureterolithotomy the urologic surgeon is faced occasionally with the complication of a displaced ureteral calculus that has migrated proximally through a dilated ureter. We report such a case and offer an alternative method of injection and extraction of a cryoprecipitate coagulum through the ureterotomy. This technique may eliminate the need for an additional incision or a possible second operative procedure.

Intranuclear inclusion bodies within neurons of spinal and cranial ganglia in three cyprinid species.

A histological examination of 205 fish representing four cyprinid species from a site 2.5 miles north of Wheeling, West Virginia, on the Ohio River revealed large (2--4 micron) cuboidal intranuclear inclusion bodies (NIB's) within neurons in the cranial and spinal ganglia of three species. Because the minnows had been caught during a yearly sampling of fish, an additional 63 minnows were taken the following year.

Lamella-particle complexes in the human placenta.

Lamella-particle complexes, similar in appearance to those found most abundantly in human hematopoietic malignancies, were seen within the cytoplasm of pericytes within the villus cores of 2 our ot 10 human placentas, 1 from a normal pregnancy and 1 from a pregnancy complicated by postpartum toxemia. Nine placentas were from term pregnancies, 6 normal and 3 complicated by toxemia, and 1 from a pregnancy complicated by premature delivery. The lamellae measured from 62-88 A in thickness and the particles from 175-220 A in diameter.

Lamella-particle complexes in nuclei of owl monkey kidney cells infected with herpesvirus saimiri.

A complex consisting of ribosome-like particles and a striated lamella occurring in stacked, tubular, and twisted ribbon-like configurations was observed in the nuclei of confluent monolayer cultures of primary owl monkey kidney cells infected with Herpesvirus saimiri. They were similar to the cytoplasmic cylindroid structures seen in some human leukemias and in the lymphoma of the northern pike.

On the activation of plasma membrane ecto-enzymes by treatment with neuraminidase.

It had been proposed that sialyl-residues on the surface of the cell control the activity of certain plasma membrane ecto-enzymes. We have tested the effects of several established (or presumptive) ecto-enzymes in tissue cultures of CNS-derived cells. Application of neuraminidases to cultured mouse neuroblastoma (N-18), neonatal Syrian hamster astrocytes (NN), human astrocytoma (Cox clone) and two lines of primary mouse astroblasts failed to change the activity of ecto-ATPase and 5'-nucleotidase.

Cylindroid lamella-particle complexes in lymphoma cells by northern pike (Esox lucius).

Cells of the malignant lymphoma of northern pike of Canada contained cylindrical structures with central cores of cytoplasmic elements and walls composed of lamellae in a spiral arrangement, separated by ribosome-like particles or by membranes. These cylindroids were similar, if not identical, to structures in the cells of certain human lymphomas and leukemias. In cross and longitudinal sections, the lamellae showed a pattern of light and dark bands resulting in an approximately 95 A-period that has not been described in the human cylindroids.

Cartilage in hemophilic arthropathy. Ultrastructural and microanalytical studies.

The presence of iron in articular cartilage was investigated in five human and two canine cases of factor VIII-deficiency hemophilic arthropathy. The lesions were mild in three cases. Advanced destruction of the cartilage was present in four cases, in one of which sufficient cartilage was preserved to permit recognition of hemosiderin in chondrocytes.

Oyster herpes-type virus.

A herpes-type virus infection, the first to be found in an invertebrate animal, is reported in the oyster Crassostrea virginica. Intranuclear herpes-type viral inclusions were more prevalent in the oyster at elevated water temperatures of 28 degrees to 30 degrees C than at normal ambient temperatures of 18 degrees to 20 degrees C. The inclusions were associated with a lethal disease at the elevated temperatures.