Publications by authors named "Bandello F"
Purpose: To report a case series of exudation in non-neovascular geographic atrophy (GA), which fluctuated and spontaneously almost resolved during the follow-up.
Methods: A retrospective study was designed to include consecutive cases with geographic atrophy (GA) secondary to age-related macular degeneration (AMD) associated with intraretinal fluid (IRF) but without macular neovascularization (MNV). Three eyes of 2 patients (one male, one female) were enrolled.
Introduction: The purpose of the study is to characterize the rate of progression of geographic atrophy (GA) areas in patients with age-related macular degeneration (AMD) with subclinical angioid streaks (AS), compared to patients with AMD without subclinical AS.
Methods: This is a retrospective, longitudinal, case-control study. Among a cohort of patients with AMD, we selected patients with GA with subclinical AS and followed them for a 2-year follow-up.
To evaluate the early real-world clinical outcomes regarding the safety and efficacy after administration of a ranibizumab biosimilar (Ranieyes). This multicenter retrospective uncontrolled observational study incorporated data from 7 centers in India. All patients were treated with at least 1 intravitreal injection of 0.
View Article and Find Full Text PDFPurpose: In this study, our goal was to deepen the understanding of the clinical significance and underlying pathogenic mechanisms of the hyperreflective ganglion cell layer (HGB) observed in optical coherence tomography (OCT) scans of patients with retinitis pigmentosa (RP).
Methods: The study was designed as observational, cross-sectional. RP patients with and without HGB were recruited and underwent complete multimodal retinal imaging assessment, including OCT, OCT angiography (OCTA) and Dense Automatic-RealTime (DART) OCTA.
Background: Pathogenic variants in the gene are linked to a spectrum of ciliopathies, which can present with ophthalmic symptoms. In this study, we describe the multimodal imaging findings of a patient with an adult-onset Stargardt-like phenotype associated with biallelic variants.
Methods: The patient underwent a comprehensive ophthalmologic evaluation, including slit-lamp examination, optical coherence tomography (OCT), fundus autofluorescence (FAF), and OCT-angiography (OCTA).
Background: To perform a three-dimensional assessment of the choroid, including choroidal volume and choroidal vascularity index (CVI), during the transition from intermediate to neovascular age-related macular degeneration (AMD), and following anti-VEGF therapy.
Methods: A total of 42 participants (42 eyes) with intermediate AMD at baseline who developed neovascular AMD within 3 months were included in the analysis. Optical coherence tomography (OCT) scans at follow-up visits (after transition to neovascular AMD and 12 months after the initiation of anti-VEGF therapy) were compared with values at the latest visit with evidence of intermediate AMD to quantify longitudinal choroidal changes.
Purpose: To describe optical coherence tomography (OCT) features of atypical congenital hypertrophy of retinal pigment epithelium (CHRPE) associated with familial adenomatous polyposis (FAP).
Methods: Case report.
Results: A 34-year-old patient diagnosed with FAP was referred to our clinic for fundus examination.
Topic: Macular atrophy incidence in neovascular age-related macular degeneration (AMD) patients undergoing anti-VEGF treatment.
Clinical Relevance: Macular atrophy is a significant event that may occur in eyes with neovascular AMD treated with anti-VEGF therapy.
Methods: We conducted a systematic review and meta-analysis following PRISMA guidelines (PROSPERO, CRD42024474924).
Purpose: This study examines the multimodal imaging (MMI) findings in two cases of unilateral Stellate Nonhereditary Idiopathic Foveomacular Retinoschisis (SNIFR), including detailed findings from the unaffected fellow eye.
Methods: Macular spectral domain optical coherence tomography (OCT) and 3x3 mm optical coherence tomography angiography (OCTA), microperimetry, full-field electroretinography (ff-ERG) for both the affected and the fellow eye were reviewed.
Results: The MMI findings were consistent across the two cases (71-year-old female and 60-year-old female).
Intravitreal injections of anti-vascular endothelial growth factor (anti-VEGF) medications are the primary treatment for neovascular age-related macular degeneration (nAMD). However, frequent administrations pose significant burdens on patients, healthcare providers, and systems. The treat-and-extend (T&E) regimen, which adjusts treatment intervals based on patient response, aims to reduce injection frequency while maintaining disease control.
View Article and Find Full Text PDFInflammatory choroidal neovascularization (iCNV) significantly contributes to vision impairment and ranks as the third primary cause of CNV. Arising from both infectious and noninfectious uveitis, iCNV's pathogenesis involves Bruch membrane rupture, local inflammation, and choriocapillaris ischemia. The diagnosis of iCNV is challenging due to its symptomatic overlap with other uveitis-related conditions.
View Article and Find Full Text PDFRetromode imaging in vitreoretinal lymphoma.
Graefes Arch Clin Exp Ophthalmol
December 2024
Purpose: The purpose of this study was to evaluate Retromode (Nidek Co., Gamagori, Japan) as an adjunct diagnostic tool in vitreoretinal lymphoma (VRL). By integrating Retromode findings with multimodal imaging, we aimed to enhance lesion detection of VRL lesions in the retina.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to evaluate the incidence and risk factors of cystoid macular edema (CME) following vitrectomy alone and after cataract surgery in patients with either rhegmatogenous retinal detachment (RRD) or idiopathic epiretinal membrane (ERM).
- A total of 498 eyes were examined, revealing that post-vitrectomy CME occurred significantly more in ERM cases (12.8%) than in RRD cases (1%).
- The findings suggest that eyes previously treated for ERM face a greater risk of developing CME after cataract surgery, indicating that the changes caused by ERM might increase susceptibility to this condition.
Extensive macular atrophy with pseudodrusen-like appearance (EMAP) was first described in France in 2009 as a symmetric and rapidly progressive form of macular atrophy primarily affecting middle-aged individuals. Despite the recent identification of a significant number of cases in Italy and worldwide, EMAP remains an underrecognized condition. The clinical triad typical of EMAP consists of vertically oriented macular atrophy with multilobular borders, pseudodrusen-like deposits across the posterior pole and mid-periphery, and peripheral pavingstone degeneration.
View Article and Find Full Text PDFPurpose: To identify baseline OCT predictors of the 3-year macular atrophy (MA) development for type 3 (T3) macular neovascularization (MNV) secondary to neovascular age-related macular degeneration (nAMD) treated by anti-VEGF therapy.
Design: Multicenter, retrospective, longitudinal study.
Participants: We included patients with treatment-naive T3 MNV secondary to nAMD at baseline, treated with anti-VEGF during a 3-year follow-up.
Purpose: To evaluate photobiomodulation (PBM) safety and efficacy in patient with atrophic AMD and to explore tissue effects using Spectrally Resolved Autofluorescence (SrAF) to identify a potential biomarker indicative of mitochondrial activity, the primary PBM target.
Methods: This retrospective, non-comparative case series involved six eyes of five patients with atrophic AMD, conducted at the Medical Retina and Imaging Unit, IRCCS San Raffaele Hospital in Milan, Italy. At baseline and follow-ups (after one and three months) a complete ophthalmological assessment and multimodal imaging, including spectrally resolved autofluorescence (SrAF), were performed.
Multifocal vitelliform lesions associated with mitochondrial retinopathy.
Am J Ophthalmol Case Rep
December 2024
Purpose: To report a case of multifocal vitelliform lesions in a patient affected by metabolic encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) with the m.3243A>G variant.
Observations: A 37-year-old woman affected by MELAS was referred to our center for progressive vision deterioration.
Article Synopsis
- The study compares structural optical coherence tomography (OCT) and infrared reflectance (IR) imaging to analyze differences in non-exudative macular neovascularizations (NE MNVs) caused by age-related macular degeneration (AMD) and those linked to the pachychoroid spectrum.
- It assessed patients with documented NE-MNVs, focusing on treatment-naïve cases that remained non-exudative for at least a year and had high-quality imaging available.
- Results indicated that NE-MNVs in pachychoroid eyes exhibited sharper, more inhomogeneous pigment epithelium detachments and were more likely to show a hyporeflective halo than those in AMD eyes.
Introduction: Despite an improved understanding of its pathogenesis, dry eye disease (DED) remains relatively underestimated and its treatment challenging. A better alignment between the clinical evaluation and the patient self-assessment also requires capturing the whole patient experience of DED. This project aimed to unveil this experience through narrative medicine (NM).
View Article and Find Full Text PDFPurpose: To explore changes in reticular pseudodrusen (RPD) number and location after the development of macular neovascularization (MNV) in eyes with prior intermediate age-related macular degeneration, focusing on different retinal regions differently affected by MNV.
Methods: This retrospective longitudinal study included intermediate age-related macular degeneration eyes with RPD that developed MNV. Reticular pseudodrusen were assessed at baseline when MNV was diagnosed (MNV stage) and after anti-vascular endothelial growth factor treatment.
Purpose: To report a challenging case of corneal descemetocele following Nd:YAG laser capsulotomy for posterior capsule opacification in a patient with Steven Johnson syndrome (SJS).
Observations: A single-eye 52 year-old man, with a history of Steven Johnson syndrome, presented with severe eye pain and profound vision reduction in his left eye two days after undergoing Nd:YAG laser capsulotomy using the standard Abraham contact lens. A corneal descemetocele was identified and subsequently confirmed by anterior segment optical coherence tomography.
Purpose: This study aims to quantify the volume of intraretinal fluid (IRF), subretinal fluid (SRF), and subretinal pigment epithelium (sub-RPE) fluid in treatment-naïve Type 3 macular neovascularization (MNV) eyes with age-related macular degeneration (AMD) and to investigate the correlation of these fluid volumes with visual acuity (VA) outcomes at baseline and following antivascular endothelial growth factor (VEGF) treatment.
Design: Retrospective, clinical cohort study.
Methods: In this study, we analyzed patients diagnosed with exudative AMD and treatment-naïve Type 3 MNV undergoing a loading dose of anti-VEGF therapy.
Article Synopsis
- The study investigated the effects of flavanol-rich dark chocolate on the anatomy and functionality of retinal vessels, using advanced imaging techniques on healthy participants.
- Twenty healthy individuals (mean age 24.4 years), consumed either dark chocolate or milk chocolate, with evaluations conducted before and two hours after consumption.
- Results showed that dark chocolate significantly improved arterial dilation in retinal vessels, suggesting potential short-term benefits, while no significant effects were observed from milk chocolate; further research is needed to explore long-term impacts on retinal health.