Notch transcriptional target tmtc1 maintains vascular homeostasis.

Proper lung function requires the maintenance of a tight endothelial barrier while simultaneously permitting the exchange of macromolecules and fluids to underlying tissue. Disruption of this barrier results in an increased vascular permeability in the lungs, leading to acute lung injury. In this study, we set out to determine whether transcriptional targets of Notch signaling function to preserve vascular integrity.

Microplastic pollution status in the coral reef ecosystems on the Southern and Western coasts of Sri Lanka during the Southwest monsoon.

We investigated the microplastics (MP) abundance, characteristics and pollution severity in the six coral reef ecosystems along the southern and western coasts of Sri Lanka during the southwest monsoon. The small blue-coloured fibres dominated within coral reefs and reef environments. The average coral, surface water and surface sediment MP concentration were 806.

Individual and Geospatial Determinants of Health Associated With School-Based Human Papillomavirus Immunization in Alberta: Population-Based Cohort Study.

Background: Human papillomavirus (HPV) infection causes nearly all cervical cancer cases and is a cause of anogenital and oropharyngeal cancers. The incidence of HPV-associated cancers is inequitable, with an increased burden on marginalized groups in high-income countries. Understanding how immunization status varies by material and social deprivation, health system, and geospatial factors is valuable for prioritizing and planning HPV immunization interventions.

Modeling the interplay between albumin-globulin metabolism and HIV infection.

Human immunodeficiency virus (HIV) infection is a major public health concern with 1.2 million people living with HIV in the United States. The role of nutrition in general, and albumin/globulin in particular in HIV progression has long been recognized.

School-based vaccination program against HPV and Hepatitis B: A longitudinal analysis of vaccine coverage between 2015 and 2021 in Quebec.

Background: HPV vaccination prevents cancers, including 90% of cervical cancer. Since 2008, a school-based HPV vaccination program has been implemented in Quebec, but vaccine coverage is suboptimal. The COVID-19 pandemic disrupted school-based vaccination programs.

Mathematical model on HIV and nutrition.

HIV continues to be a major global health issue, having claimed millions of lives in the last few decades. While several empirical studies support the fact that proper nutrition is useful in the fight against HIV, very few studies have focused on developing and using mathematical modelling approaches to assess the association between HIV, human immune response to the disease, and nutrition. We develop a within-host model for HIV that captures the dynamic interactions between HIV, the immune system and nutrition.

The longitudinal effects of the built environment on transportation and recreational walking, and differences by age and sex: systematic review protocol.

Background: In high-income countries, the prevalence of physical inactivity and non-communicable diseases is high, and it is now well-established that insufficient physical activity is a risk factor for non-communicable diseases. Walking for recreation and transportation are effective means of improving population levels of physical activity. Research finds that the built environment (BE) can encourage or discourage walking behaviour, and this association varies for different age groups and sexes.

"The problem is not lack of information": A qualitative study of parents and school nurses' perceptions of barriers and potential solutions for HPV vaccination in schools.

Background: HPV vaccination has been offered in school programs for over a decade in Quebec, Canada, but the vaccine coverages are not reaching the target coverage in several regions. This qualitative study aimed to describe barriers and enabling conditions of HPV vaccination as perceived by parents and school nurses and identify potential solutions to improve HPV vaccine uptake rates and acceptance in school-based programs.

Methods: Three focus group discussions were conducted with parents of children in Grades 2 or 3 who were unsure or unwilling to vaccinate.

Sustainable mining of natural vein graphite via acid-extraction from waste attached to rock pieces of vein banks.

A procedure based on acid extraction using a mixture of conc. sulfuric and nitric acids (8:1) to recover graphite attached to rock pieces of the vein contact zones of graphite mines, is developed as a sustainable mining practice. When the extracted graphite is heated at 600 °C for 15 min, it is converted to a highly expanded form resembling worm-like structures.

Impact of economic globalisation on value-added agriculture, globally.

Economic globalisation is the integration of national economies into the global economy through the increasing flow of goods, services, capital, and technology across borders and it has contributed to garnering a significant portion of most nations' national income, although its agricultural value-added aspect has yet to be maximised. This pioneering study explores the impact of economic globalisation on value-added agriculture in a global context based on countries' income levels. Panel data regression with the stepwise method was employed to quantify the impact of economic globalization on agriculture value added in 101 countries between 2000 and 2021.

Rapid Sequence Intubation Using the SEADUC Manual Suction Unit in a Contaminated Airway.

The case presented here highlights the utility/feasibility of the SEADUC (EM Innovations, Galloway, OH) manual suction unit in clearing a contaminated airway during rapid sequence intubation. The case also highlights the importance of intubation in a patient with declining mental status in the prehospital environment. A 75-year-old woman suffered a head injury, and a helicopter emergency medical service team staffed with a physician and nurse was tasked with retrieval and transfer back to the tertiary care center.

Retention of essential fatty acids in fish differs by species, habitat use and nutritional quality of prey.

Algae-produced long-chain polyunsaturated fatty acids (LC-PUFA; with ≥20 carbon atoms) are key biomolecules for consumer production and animal health. They are transferred to higher trophic levels and accumulated in food chains. However, LC-PUFA accumulation in consumers and their trophic transfer vary with the diet quality and the physiological demand for LC-PUFA of consumers.

Hematopoietic Jagged1 is a fetal liver niche factor required for functional maturation and engraftment of fetal hematopoietic stem cells.

Notch signaling is essential for the emergence of definitive hematopoietic stem cells (HSCs) in the embryo and their development in the fetal liver niche. However, how Notch signaling is activated and which fetal liver cell type provides the ligand for receptor activation in HSCs is unknown. Here we provide evidence that endothelial Jagged1 (Jag1) has a critical early role in fetal liver vascular development but is not required for hematopoietic function during fetal HSC expansion.

Metabolic and Endocrine Complications of Long-COVID-19: A Review.

Over the past two years, the outbreak of coronavirus disease of 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has centralized the interest of the health care systems and the scientific world. The majority of COVID-19-infected individuals recover fully. However, about 12-50% of patients experience various mid- and long-term effects after recovering from the initial illness.

Multimethod Process Evaluation of a Community Paramedic Delivered Care Transitions Intervention for Older Emergency Department Patients.

Objective: We assessed fidelity of delivery and participant engagement in the implementation of a community paramedic coach-led Care Transitions Intervention (CTI) program adapted for use following emergency department (ED) visits.

Methods: The adapted CTI for ED-to-home transitions was implemented at three university-affiliated hospitals in two cities from 2016 to 2019. Participants were aged ≥60 years old and discharged from the ED within 24 hours of arrival.

The effects of biochar aging on rhizosphere microbial communities in cadmium-contaminated acid soil.

Biochars are widely used in the remediation of Cd-contaminated soils. However, changes in the bacterial communities in the rhizosphere contaminated with Cd in response to biochar aging are poorly studied. Addressing this gap in knowledge is important to improving micro-ecological services on healthy growth of plants with mitigation strategies against Cd contamination.

Dataset on seston and zooplankton fatty-acid compositions, zooplankton and phytoplankton biomass, and environmental conditions of coastal and offshore waters of the northern Baltic Sea.

We analyzed the taxonomic and fatty-acid (FA) compositions of phytoplankton and zooplankton, and the environmental conditions at three coastal and offshore stations of the northern Baltic Sea. Plankton samples for FA analyses were collected under the framework of sampling campaigns of the Swedish National Marine Monitoring program in September 2017. Monitoring data of phytoplankton and zooplankton biomass, and environmental variables at each station were extracted from the Swedish Meteorological and Hydrological Institute database (https://sharkweb.

A Notch/IL-21 signaling axis primes bone marrow T cell progenitor expansion.

Long-term impairment in T cell-mediated adaptive immunity is a major clinical obstacle following treatment of blood disorders with hematopoietic stem cell transplantation. Although T cell development in the thymus has been extensively characterized, there are significant gaps in our understanding of prethymic processes that influence early T cell potential. We have uncovered a Notch/IL-21 signaling axis in bone marrow common lymphoid progenitor (CLP) cells.

An equity-based assessment of immunization-related responses in urban Alberta during the 2014 measles outbreak: a comparative analysis between Calgary and Edmonton.

Objectives: This study investigates measles, mumps, and rubella (MMR) immunization rates during the measles outbreak in Calgary and Edmonton of 2014 stratified by four area-level socio-demographic indicators. This study also leverages this epidemiological data to assess the equity aspect of emergency measures instituted regarding immunization in those two cities.

Methods: A mixed-methods comparative case study analysis methodology was employed to assess the neighbourhood-level immunization statuses before (2013), during (2014), and after (2015) an active measles outbreak in Calgary and Edmonton, Alberta, Canada.

Surveying the local public health response to COVID-19 in Canada: Study protocol.

Background: Public health services and systems research is under-developed in Canada and this is particularly the case with respect to research on local public health unit operational functioning and capacity. The purpose of this paper is to report on a study that will collect retrospective information on the local public health response to COVID-19 throughout Canada between 2020 and 2021.

Methods/design: The goal of the study is to develop and implement a study framework that will collect retrospective information on the local public health system response to the COVID-19 pandemic in Canada.

Biochar aging alters the bioavailability of cadmium and microbial activity in acid contaminated soils.

The effects of biochar aging on heavy-metal bioavailability and microbial activity are not fully understood. This study determined the effect over 270 days of poultry-litter biochar (PBC) and sugar-gum-wood biochar (SBC) on the bioavailability of Cd and microbial activity in acidic soils differing in organic matter content. Soil basal and substrate-induced respirations, microbial properties, Cd bioavailability and plant Cd bioaccumulation were evaluated at 1, 30, 90 and 270 days.

Staff Perceptions of a Mealtime Management Educational Video for Training in Long-Term Care Homes.

The purpose of this study was to determine if staff perceive a mealtime management video to be a beneficial and useful training tool in long-term care (LTC) homes. An email invitation was sent to the Dietitians of Canada Gerontology Network inviting dietitians working in LTC homes to participate. A previously used and reliable 25-item questionnaire was used to assess sustained attention/mental effort, learner satisfaction, clinical experience/relevance, and information processing of the video.

A dual enhancer-silencer element, DES-K16, in mouse spermatocyte-derived GC-2spd(ts) cells.

The multifunctionality of genome is suggested at some loci in different species but not well understood. Here we identified a DES-K16 region in an intron of the Kctd16 gene as the chromatin highly marked with epigenetic modifications of both enhancers (H3K4me1 and H3K27ac) and silencers (H3K27me3) in mouse spermatocytes. In vitro reporter gene assay demonstrated that DES-K16 exhibited significant enhancer activity in spermatocyte-derived GC-2spd(ts) and hepatic tumor-derived Hepa1-6 cells, and a deletion of this sequence in GC-2spd(ts) cells resulted in a decrease and increase of Yipf5 and Kctd16 expression, respectively.