Upregulation of Toll-Like Receptors 2, 5, 7, and 9 in the Cervical Epithelial Cells of Iranian Women Infected with High-Risk Human Papilloma Virus.

Background: Toll-like receptors (TLRs) play dual roles against viruses, including defense against the viruses and induction of the viral-related cancers. High risk human papilloma viruses (HPVs) play key roles in induction of HPV-related cancers. The molecules that are upregulated by the high-risk viruses can be considered as the candidate to induce the cancers.

TLR9 in the Human Papilloma Virus Infections: Friend or Foe?

Immune system plays dual roles during human papilloma virus (HPV) infections, from defense against the virus to induction or stimulation of the HPV-related cancers. It appears that various differences within the immune-related genes and the functions of the immunological parameters of the patients are the main factors responsible for the roles played by immune system during HPV infections. Toll-like receptors (TLRs) play key roles in the recognition of viruses and activation of immune responses.

Preparation and Evaluation of the Antibacterial Effect of Magnetic Nanoparticles Containing Gentamicin: A Preliminary Study.

Background: Magnetic nanoparticles (MNPs) loaded by various active compounds can be used for targeted drug delivery. Objectives: In the present study, the FeO magnetic nanoparticles that contained gentamicin were prepared and their antibacterial activities were studied.

Materials And Methods: MNPs containing gentamicin (G@SA-MNPs) were prepared using sodium alginate (SA) as a surface modifier.

Identification of Carbapenem-Resistant Klebsiella pneumoniae with Emphasis on New Delhi Metallo-Beta-Lactamase-1 (bla) in Bandar Abbas, South of Iran.

Background And Objective: The spread of carbapenem-resistant Klebsiella pneumoniae especially bla-carrying isolates is a great concern worldwide. In this study we describe the molecular basis of carbapenem-resistant K. pneumoniae in three teaching hospitals at Bandar Abbas, south of Iran.

Gut Microbiota and IL-17A: Physiological and Pathological Responses.

IL-17A is a cytokine which is produced by several immune and non-immune cells. The cytokine plays dual roles from protection from microbes and protection from pro-inflammatory based diseases to induction of the pro-inflammatory based diseases. The main mechanisms which lead to the controversial roles of IL-17A are yet to be clarified.