Facile Ru-catalysed synthesis of quinazolin-4(3)-ones by tandem cyclization of 2-nitrobenzonitrile and alcohol derivatives under air.

We have developed an efficient approach for the first Ru-catalysed synthesis of 2-arylquinazolin-4(3)-ones from 2-nitrobenzonitriles and alcohols. This method features a broad substrate scope, high yields, and functional group tolerance and does not require any oxidant or reductant, allowing for simple, practical and sustainable synthesis.

FeBr-catalysed synthesis of 3-aroylimidazo[1,2-]pyridine and 3,3'-(arylmethylene)bis(2-phenylimidazo[1,2-]pyridines) derivatives from 2-arylimidazo[1,2-]pyridines and aromatic aldehydes: an investigation about mechanistic insights.

In a new approach, a series of 3-aroylimidazo[1,2-]pyridine derivatives were prepared in high yields. This approach revealed the direct Fe-catalyzed functionalization of imidazo[1,2-]pyridine derivatives with aryl aldehydes an aerobic oxidative cross-dehydrogenative coupling process. This transformation occurred in the presence of air, and FeBr served as a homogeneous Lewis catalyst.

Design and Synthesis of Novel β-Carboline-Bisindole Hybrids as Potential Anticancer Agents.

We are reporting a short and convenient pathway for the synthesis of novel β-carboline-bisindole hybrid compounds from relatively cheap and commercially available chemicals such as tryptamine, dialdehydes and indoles. These newly designed compounds can also be prepared in high yields with the tolerance of many functional groups under mild conditions. Notably, these β-carboline-bisindole hybrid compounds exhibited some promising applications as anticancer agents against the three common cancer cell lines MCF-7 (breast cancer), SK-LU-1 (lung cancer), and HepG2 (liver cancer).

Facile access to 5-thiazolo[2',3':2,3]imidazo[4,5-]indole derivatives by two-fold Cu-catalysed C-N coupling reactions.

In four simple steps, a series of 5-thiazolo[2',3':2,3]imidazo[4,5-]indole and 11-benzo[4',5']thiazolo[2',3':2,3]imidazo[4,5-]indole derivatives were prepared with high yields. The key step in this procedure was demonstrated to be two-fold Cu-catalysed C-N coupling reactions of 5-bromo-6-(2-bromophenyl)imidazo[2,1-]thiazole and 3-bromo-2-(2-bromophenyl)benzo[]imidazo[2,1-]thiazole with various amines.

Practical Synthesis of 1,4-Dihydropyridines on Heterogeneous Sulfonicmodified Silica (SBA-15-SOH) Catalyst Under Mild Condition.

Aims: Synthesis of 1,4-Dihydropyridines (1,4-DHP) using heterogeneous catalyst under mild condition.

Objective: Our objective is to explore new applications of non-metal heterogeneous catalysts in the synthesis of 1,4-DHP derivatives in a greener and more efficient approach.

Methods: A greener and more efficient method for the synthesis of 1,4-DHPs and an asymmetric 1,4-DHP (Felodipine drug) was successfully developed in high yields using a heterogeneous SBA- 15-SOH catalyst.

Facile iodine-promoted synthesis of bis(1-imidazo[1,5-]pyridyl)arylmethanes and exploration of applications.

A practical strategy for the iodine-promoted synthesis of bis(1-imidazo[1,5-]pyridyl)arylmethane and its derivatives has been developed. These compounds exhibit high cytotoxicity toward various cancer cell lines and moreover they are promising ligands for the Cu-catalysed synthesis of quinolines.