Systematic review of the diagnostic accuracy of 201Tl single photon emission computed tomography in the detection of recurrent glioma.

Objective: To determine the diagnostic accuracy of 201Tl SPECT in the detection of tumour recurrence in patients with previous radiotherapy for supratentorial glioma.

Methods: The databases of PubMed and Embase were searched for relevant studies. Two reviewers independently selected and extracted data on study characteristics, quality and accuracy of studies.

Interobserver variability in the semi-quantitative assessment of 201Tl SPECT in cerebral gliomas.

Objectives: 201Tl SPECT is used successfully in the diagnosis of recurrent supratentorial glioma and in the evaluation of its response to chemotherapy. However, different methods are used to measure relative tracer uptake in tumour and background. The objective of this study was to assess the interobserver variability of such methods, and, if possible, to provide nomograms for data conversion.