[PATIENT'S RIGHT TO PRIVACY IN THE HEALTH CARE SECTOR].

The purpose of the article is to consider the issues of ensuring confidentiality in the field of healthcare and to propose ways to solve the problems of real practical ensuring of the rights of patients to privacy. It is indicated that the right to privacy is implemented in various spheres of public life, and confidentiality in the health sector is an actual problem. It is necessary to protect the patient not only within the range of the provision of medical care or the implementation of medical services, but also from a legal perspective.

Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures.

Despite high initial efficacy, targeted therapies eventually fail in advanced cancers, as tumors develop resistance and relapse. In contrast to the substantial body of research on the molecular mechanisms of resistance, understanding of how resistance evolves remains limited. Using an experimental model of ALK positive NSCLC, we explored the evolution of resistance to different clinical ALK inhibitors.

NEUROLAW: BRANCH OR SECTION OF NEW SIENCES, A COMPLEX BRANCH OF LAW OR A WAY TO JUSTIFY CRIMINALS (REVIEW).

The purpose of the article is to consider comprehensively the phenomenon of the neurolaw, assessing it as a product of bioethics and behaviorism, a likely separate branch of law or the institution of medical law, as well as to analyze the feasibility of its introduction in the national justice system or refusal from it as a way of avoiding the responsibility of criminals. In general, the neurolaw is an interdisciplinary, intersectoral sphere of knowledge, formed on the basis of applying the results of researches in the field of medicine (in particular, neurology) in jurisprudence. This became possible, since human behavior (especially in the case of deviations from the norm) can sometimes be explained only with the help of anatomy, biochemistry and physiology of the nervous system.

Euthanasia or palliative care: legal principles of the implementation in the context of the realization of human rights to life.

Objective: Introduction: The right to life - is natural inherent human right, the fundamental principle of the existence of mankind, recognized by all civilized countries. It is enshrined in numerous international and national legal acts as the most important benefit of a man. However, there are discussions about the use of euthanasia.

Two closely related human members of chitinase-like family, CHI3L1 and CHI3L2, activate ERK1/2 in 293 and U373 cells but have the different influence on cell proliferation.

The activation of extracellular signal-regulated kinases (ERK1/2) has been associated with specific outcomes. Sustained activation of ERK1/2 by nerve growth factor (NGF) is associated with translocation of ERKs to the nucleus of PC12 cells and precedes their differentiation into sympathetic-like neurons whereas transient activation by epidermal growth factor (EGF) leads to cell proliferation. It was demonstrated that different growth factors initiating the same cellular signaling pathways may lead to the different cell destiny, either to proliferation or to the inhibition of mitogenesis and apoptosis.

Expression of genes belonging to the IGF-system in glial tumors.

Increased expression of the insulin-like growth factor (IGF) family members, IGF1, IGF2, their receptors and binding proteins, or combinations thereof has been documented in various malignancies including gliomas. The results of multiple investigations suggest that the IGFs can play a paracrine and/or autocrine role in promoting tumor growth in situ during tumor progression but that these roles may vary depending on the tissue of origin. Enhanced IGF1 expression was not found in glioblastomas and it was supposed that IGF1 participation in the development of glial tumors may be substituted by protein products of highly expressed other genes, also participating in PI3K and MAPK pathways.

Gene Encoding Chitinase 3-Like 1 Protein (CHI3L1) is a Putative Oncogene.

An important task in understanding oncogenesis is the identification of those genes whose copy number and expression increase during tumorigenesis. Previously, in an effort to identify genes which could be used as molecular markers for glial tumors, we compared gene expression in glioblastoma to the normal brain cells. Among the genes with the most pronounced increased expression in tumors there was CHI3L1, encoding the secreted chitinase 3-like 1 protein (also known as HC gp-39 or YKL-40).

Immortalized cells and one oncogene in malignant transformation: old insights on new explanation.

Background: Nearly thirty years ago, it was first shown that malignant transformation with single oncogene necessarily requires the immortal state of the cell. From that time this thesis for the cells of human origin was not disproved. The basic point which we want to focus on by this short communication is the correct interpretation of the results obtained on the widely used human embryonic kidney 293 (HEK293) cells.