[The expression of TLR4 and HBD3 in epithelial cells of oral mucosa by surgical treatment of periodontitis].

The expression of TLR4 and HBD3 in epithelial cells of the oral cavity was studied using polymerase chain reaction in real-time in patients with inflammatory and destructive periodontal lesions before and after surgery using osteoplastic material. Analysis of TLR4 and HBD3 expression in epithelial cells demonstrates the key role of the innate immune factors in the pathogenesis of inflammatory and destructive periodontal lesions. TLR4 gene expression was increased 1.

[Conditionally pathogenic microorganisms in patients with bisphosphonate jaw osteonecrosis].

The objective of the study was to define treatment strategy in cases of facial bones bisphosphonate induced osteonecrosis based on the study of the role of conditionally pathogenic oral microorganisms. Three typical clinical cases of bisphosphonate osteonecrosis of the facial bones were analyzed and 15 conditionally pathogenic oral microorganisms were identified in these patients using real-time PCR in saliva, wound and bone samples. A comparative analysis was carried out with purulent-inflammatory diseases of maxillofacial area.

[Indication and technique of human fibrinogen/thrombin-coated collagen patch use in mucogingival surgery].

The aim of the study was to assess the effectiveness of fibrinogen/thrombin-coated collagen patch by mucogingival operations in patients with somatic diseases. Twenty-seven patients aged 25 to 45 (15 males and 12 females) with somatic diseases such as arterial hypertension (11 patients), diabetes (8 patients), bleeding disorders (8 patients) underwent Edlan-Mejcher vestibuloplasty. Using fibrinogen/thrombin-coated collagen patch as wound dressing caused marked hemostatic effect in 3 to 5 minutes even in hypertension and bleeding disorder patients.

[Cytokines level in patients with drug-induced jaw necrosis].

The study included 15 patients with purulent inflammatory diseases of maxillofacial area and 25 patients with facial bone necrosis induced by synthetic drugs. Pro- and anti-inflammatory cytokines levels in saliva and wound fluid were analyzed in two groups. The results proved cytokines to play important role in jaw necrosis induced by drugs containing red phosphorus.

[Defensins level in patients with inflammatory diseases of maxillofacial area].

Molecular study of congenital immune factors was conducted in 45 patients with inflammatory diseases of maxillofacial area. The study focused on expression of cationic low-molecular peptides α- and Β-defensines in oral mucosa. These peptides are involved in antibacterial activity and regulation of immune reactions.

[Role of oral cavity anaerobic microflora in the pathogenesis of mandible traumatic osteomyelitis].

The role of conditionally pathogenic microflora in the pathogenesis of lower jaw bone traumatic osteomyelites was investigated. The different groups of aerobic and anaerobic microorganisms were detected by real-time PCR. Role of conditionally pathogenic microflora in the pathogenesis of traumatic osteomielytis was shown.